 | Meryl Streep als Jane Adler |
 | Steve Martin als Adam Schaffer |
 | Alec Baldwin als Jake Adler |
 | John Krasinski als Harley |
 | Lake Bell als Agness Adler |
 | Mary Kay Place als Joanne |
 | Rita Wilson als Trisha |
 | Ali Wentworth als Diane |
 | Hunter Parrish als Luke Adler |
 | Zoe Kazan als Gabby Adler |
 | Caitlin FitzGerald als Lauren Adler |
 | Emjay Anthony als Pedro Adler |
 | Nora Dunn als Sally |
 | Bruce Altman als Ted |
 | Robert Curtis Brown als Peter |
 | James Patrick Stuart als Dr. Moss |
 | Peter MacKenzie als Dr. Allen |
 | Sean Hamrin als Oliver |
 | Emily Kinney als Waitress |
 | Valente Rodriguez als Reynaldo |
 | Marina Squerciati als Melanie |
 | Blanchard Ryan als Woman at Fertility Clinic |
 | Geneva Carr als Woman at Fertility Clinic |
 | Jennifer Restivo als Woman at Bar |
 | Dana Power als Woman at Bar |
| Hans Zimmer | Original Music Composer |
| Sonia Grande | Costume Design |
| Ellen Chenoweth | Casting |
| Jon Hutman | Production Design |
| John Toll | Director of Photography |
| Scott Rudin | Producer |
| Joe Hutshing | Editor |
| David Moritz | Editor |
| W. Steven Graham | Art Direction |
| Beth A. Rubino | Set Decoration |
| Nancy Meyers | Screenplay |
| Nancy Meyers | Director |
| Nancy Meyers | Producer |
| Ilona Herzberg | Executive Producer |
| Joseph A. Campayno | Makeup Artist |
| J. Roy Helland | Makeup & Hair |
| Heitor Pereira | Original Music Composer |
| Kevin Kaska | Orchestrator |
| Suzanne Farwell | Executive Producer |
| Jane Choi | Makeup Artist |
| Barbara Lorenz | Hairstylist |
| Patricia Regan | Key Makeup Artist |
| Margot Boccia | Makeup Department Head |
| Fríða Aradóttir | Hair Department Head |
| Laurel Kelly | Key Hair Stylist |
| Anita Brabec | Key Makeup Artist |
| Susan Schectar | Hairstylist |
| James P. Whalen | Transportation Captain |
| Dallas Hartnett | Key Hair Stylist |
| Rose Chatterton | Key Hair Stylist |
| Maria Alejandra Garcia | Makeup Artist |
| Valerie Gladstone-Appel | Hairstylist |
| Joseph Regina | Makeup Artist |
| Jeong-Hwa Fonkalsrud | Makeup Artist |
| David Brian Brown | Hairstylist |
| Cyndilee Rice | Makeup Artist |
