 | Joey Lauren Adams als Alyssa Jones |
 | Ben Affleck als Holden McNeil |
 | Fred Armisen als Merkin |
 | Diedrich Bader als Security Guard |
 | Melissa Benoist als Chronic |
 | Jason Biggs als Jason Biggs |
 | Aparna Brielle als Jihad |
 | Adam Brody als Clerk |
 | Brian O'Halloran als Cast Member of Clerks / Dante Hicks / Grant Hicks |
 | Marilyn Ghigliotti als Cast Member of Clerks |
 | Walt Flanagan als Cast Member of Clerks |
 | Scott Schiaffo als Cast Member of Clerks |
 | Ernest O'Donnell als Cast Member of Clerks |
 | John Willyung als Cast Member of Clerks |
 | Tommy Chong als Alfred the Butler |
 | Bryan Johnson als Comic Book Man |
 | Ming Chen als Comic Book Man |
| Mike Zapcic als Comic Book Man |
 | Keith Coogan als Keith Coogan |
 | David Dastmalchian als Nervous Cop |
 | Rosario Dawson als Reggie |
 | Treshelle Edmond als Sopapilla |
 | Shannon Elizabeth als Justice |
 | Dan Fogler als Con-Ployee |
 | Ralph Garman als Ted Underhill |
 | Ben Gleib als Big Gun Guy |
| Mickey Gooch Jr. als Holy Roller |
 | Chris Hemsworth als Chris Hemsworth |
 | Chris Jericho als Klan Leader |
 | Val Kilmer als Bluntman |
 | Jason Lee als Brodie |
 | Justin Long als Lawyer |
 | Joe Manganiello als Bailliff |
| Logan Lee Mewes als Amy |
 | Kate Micucci als Mooby's Fun-ployee |
 | Redman als Redman |
 | Donnell Rawlings als Captain |
 | Jesse Rath als French Canadian Blunt-Fan |
 | Joseph D. Reitman als 1st AD |
 | Craig Robinson als Judge Jerry N. Executioner |
 | Jennifer Schwalbach Smith als Mooby's Manager Miss McKenzie |
 | Molly Shannon als SouthBest Airlines Lady |
 | Frankie Shaw als Prosecutor |
 | Method Man als Method Man |
 | Harley Quinn Smith als Milly |
 | Karrueche Tran als Con-Ployee #2 |
 | James Van Der Beek als James Van Der Beek |
 | Alice Wen als Shan Yu |
 | Chris Wood als Blunt-Fan |
 | Kevin Smith als Silent Bob / Kevin Smith |
 | Jason Mewes als Jay |
 | Johnny 'Bananas' Devenanzio als Guy with Banana |
 | Marc Bernardin als Sleepy Blunt-Fan |
 | Jeff Chase als Pitchfork Guy |
| Chelsey Cole als Walking Dead Fan |
| Eric Corrasco als Chicago Ride Me Now Driver |
| Nick Fehlinger als Kush Boy #2 |
 | Kevin Foster als Iron Bob |
| Leah Knauer als Con-Ployee #3 |
 | David Mandel als Mooby's Coffee Addict |
| Andrew McElfresh als Mooby's Cook |
 | Jordan Monsanto als Lady Bailiff |
 | Brian Quinn als Bluntman Cosplayer |
 | Jake Richardson als Kush Boy #1 |
 | Stephen Root als Cockmando (voice) |
| Virginia Smith als Con Woman |
| Andrew Singer als Popcorn Eater |
| Donald Smith als Jay Cosplayer |
| Grace Smith als Silent Bob Fan |
 | Matt Damon als Loki (uncredited) |
 | Stan Lee als Stan Lee (archive footage) (uncredited) |
 | Liv Banks als Jogger |
 | Ryan James als Chronic Con Contest Winner / Jay Cosplayer (uncredited) |
| Kevin Smith | Writer |
| Kevin Smith | Director |
| Hunter Brown | Art Direction |
| Jonathan Cappel | Set Decoration |
| Melissa Walker | Costume Design |
| Elizabeth Destro | Producer |
| Kevin Smith | Editor |
| James L. Venable | Original Music Composer |
| Nate Jones | Production Design |
| Yaron Levy | Director of Photography |
| Jordan Monsanto | Producer |
| Meagan Lewis | Casting |
| Jason Mewes | Executive Producer |
| Jennifer Schwalbach Smith | Executive Producer |
| Bill Block | Executive Producer |
| Wilford V. Bromiley | Executive Producer |
| Shanan Becker | Executive Producer |
| Jonathan Saba | Executive Producer |
| Ness Saban | Executive Producer |
| Ali Jazayeri | Executive Producer |
| David Gendron | Executive Producer |
| Michael Hansen | Executive Producer |
| R. Bryan Wright | Executive Producer |
| David Pomier | Executive Producer |
| Mickey Gooch Jr. | Executive Producer |
| Diane Gooch | Executive Producer |
| Sayres Heady | Executive Producer |
| Tracey Landon | Line Producer |
| Armen V. Kevorkian | Visual Effects Supervisor |
| Aminé Ramer | Music Supervisor |
| Tracey Landon | Unit Production Manager |
| Dan Katzman | First Assistant Director |
| Seth Hansen | Second Assistant Director |
| Andy Dylan | Stunt Coordinator |
| Walker Babington | Stunts |
| Hunter Baxley | Stunts |
| Tim Bell | Stunts |
| Todd Bloomer | Stunts |
| Sean Paul Braud | Stunts |
| Jeff Brockton | Stunts |
| Jeff Chase | Stunts |
| Matt Cipro | Stunts |
| Danny Cosmo | Stunts |
| Kevin Foster | Stunts |
| Adam Horwitz | Stunts |
| Rob Mars | Stunts |
| Chuck Picerni Jr. | Stunts |
| Preston Schrag | Stunts |
| Michael Yahn | Stunts |
| Shannon Houchins | Executive Producer |
| Potsy Ponciroli | Executive Producer |
| Trevor O'Neil | Executive Producer |
| Tara Finegan | Executive Producer |
| Philip Moross | Executive Producer |
| Dominic Burns | Co-Producer |
| Daniel McGilvray | Co-Producer |
| Chelsey Cole | Associate Producer |
| Bree Doehring | Associate Producer |
| Dan Katzman | Associate Producer |
| Theresa Hernandez | Casting Associate |
| Brent Caballero | Extras Casting |
| Charlotte Gale | Extras Casting Coordinator |
| Jay DeFelice | Extras Casting Coordinator |
| Harrison Huffman | Production Supervisor |
| Patrick McBride | Production Coordinator |
| Corry Lane | Assistant Production Coordinator |
| Nick DiRosa | Script Supervisor |
| Federico Verardi | "A" Camera Operator |
| Zachary Sieffert | "B" Camera Operator |
| Loui J. LeRoy | First Assistant "A" Camera |
| Charlie Nauman | First Assistant "B" Camera |
| John Scott Williams | Second Assistant "A" Camera |
| Larron Rome Julian | Second Assistant "B" Camera |
| David C. Edwards | Additional Second Assistant Camera |
| Toni Weick | Additional Second Assistant Camera |
| Kyle Bono Kaplan | Still Photographer |
| Brett Murray | Production Sound Mixer |
| Brad Lokey | Boom Operator |
| Michael David Smith | Utility Sound |
| Anastasiya Rul | Dialect Coach |
| Shannon Jantz | Costume Supervisor |
| Heather Rae Miller | Key Costumer |
| Marie Boensch | Truck Costumer |
| Kayla Berry | Set Costumer |
| Alaina Boyett | Set Costumer |
| Sebastian Rey | Set Costumer |
| Kelsey Reine | Costume Assistant |
| Tori Sherman | Costume Assistant |
| Natalie Shea Rose | Hair Department Head |
| Cammy Crochet | Key Hair Stylist |
| Emily Dawn Christison | Hairstylist |
| Chelsea Barber | Additional Hairstylist |
| Timothy Blackburn | Additional Hairstylist |
| Dominique Brock | Additional Hairstylist |
| Madeline Brown | Additional Hairstylist |
| H. Scott Broome | Additional Hairstylist |
| Kimberly Burrell | Additional Hairstylist |
| Lauren Butler | Additional Hairstylist |
| Chantelle Calmes | Additional Hairstylist |
| Jim Compton | Additional Hairstylist |
| Oscar Gale | Additional Hairstylist |
| Wade Hampton | Additional Hairstylist |
| Bailey Osorno Lavin | Additional Hairstylist |
| Jessica Masters | Additional Hairstylist |
| Terez Ordon | Additional Hairstylist |
| Crystal Wells | Additional Hairstylist |
| Miranda Welsh | Additional Hairstylist |
| Carla Brenholtz | Makeup Department Head |
| Natalie Johnson | Key Makeup Artist |
| Edward Joubert | Special Effects Coordinator |
| Stephen Meagher | Special Effects Technician |
| Robert Dierx | Second Second Assistant Director |
| Jean Dalsin | Additional Second Assistant Director |
| Lauren Ito | Art Department Coordinator |
| Dave Kelsey | Set Designer |
| Michelle Jones | Graphic Designer |
| Brayden Benton | Additional Set Dresser |
| Zack Dickerson | Set Dresser |
| Brian Mccolgan | Set Dresser |
| Paul Pitalo | Set Dresser |
| Smith C. Stickney | Set Dresser |
| Elliot Westphal | On Set Dresser |
| Sam Hensen | Additional Set Dresser |
| Allen Jaeger Jr. | Additional Set Dresser |
| Peter Jacob Jones | Additional Set Dresser |
| Dunbar Merrill | Additional Set Dresser |
| Whitney Ryan Spangler | Additional Set Dresser |
| Hunter Spears | Additional Set Dresser |
| Ashley Torregano, Sr. | Additional Set Dresser |
| Jeremy Williams | Additional Set Dresser |
| J.C. Reifenberg | Assistant Editor |
| Anna Holley | Assistant Editor |
| Jon Vogl | Sound Supervisor |
| Jon Vogl | Sound Re-Recording Mixer |
| Marc Meyer | Sound Effects Editor |
| Jon Vogl | Dialogue Editor |
| Aidan Dykes | ADR Editor |
| Arno Stephanian | Foley Mixer |
| Sanaa Kelley | Foley Artist |
| Matt Salib | Foley Artist |
| Arno Stephanian | Foley Editor |
| Julie Altus | ADR Supervisor |
| Aidan Dykes | ADR Mixer |
| Kevin Crehan | Music Editor |
| James Baldanzi | Visual Effects Supervisor |
| James Baldanzi | Visual Effects Producer |
| Patrick Ottinger | Visual Effects Coordinator |
| Erin Bosworth | Compositing Supervisor |
| Andranik Taranyan | Digital Supervisor |
| Tyler Bennink | Visual Effects Coordinator |
| Maria Markarian | Visual Effects Coordinator |
| Louis Polak | Visual Effects Coordinator |
| Neil Van Dijk | Visual Effects Coordinator |
| Sean Wright | Visual Effects Coordinator |
| Frederik Bokkenheuser | Colorist |
| Steven White | Online Editor |
| Will Taggart | Music Coordinator |
| Tyler Hohmann | Assistant Location Manager |
| Tony Malzone | Producer |
