 | Debi Derryberry als Jimmy Neutron (voice) |
 | Tara Strong als Timmy / School Girl (voice) |
 | Rob Paulsen als Carl / Anti-Fairy Walla (voice) |
 | Jeffrey Garcia als Sheen / Anti-Fairy Walla (voice) |
 | Carolyn Lawrence als Cindy Vortex (voice) |
 | Crystal Scales als Libby Folfax (voice) |
 | Frank Welker als Goddard (voice) |
 | Susanne Blakeslee als Wanda / Mom / Anti-Wanda / Anti-Fairy #1 (voice) |
 | Daran Norris als Cosmo / Dad / Jorgen Von Strangle / Anti-Cosmo (voice) |
 | Carlos Alazraqui als Mr. Crocker (voice) |
 | Dee Bradley Baker als Binky (voice) |
 | Gary LeRoi Gray als A.J. (voice) |
 | Jim Ward als Chet Ubetcha / Anti-Fairy #2 (voice) |
 | Jeff Bennett als Dr. Moist (voice) |
 | Kevin Michael Richardson als Morgan Freeman / Anti-Fairy Walla (voice) |
 | Tim Curry als Professor Finbarr Calamitous (voice) |
 | Chris Kirkpatrick als Chip Skylark (voice) (archive audio) (uncredited) |
 | Grey DeLisle als Vicky (voice) |
| Steve Oedekerk | Executive Producer |
| Guy Moon | Music |
| John A. Davis | Creator |
| Keith Alcorn | Director |
| Keith Alcorn | Co-Executive Producer |
| Steve Marmel | Screenplay |
| Steve Marmel | Story |
| Jack C. Thomas | Story |
| Butch Hartman | Director |
| Butch Hartman | Executive Producer |
| Butch Hartman | Creator |
| Mike Gasaway | Director |
| Gene Grillo | Screenplay |
| Gene Grillo | Story |
| Rico Hill | Original Concept |
| Fred Seibert | Executive Producer |
| Jed Spingarn | Story |
| Jed Spingarn | Co-Executive Producer |
| Bob Boyle | Producer |
| Paul Marshal | Producer |
| Charlie Brissette | Music |
| Tony Bonilla | Animation |
| Dave Thomas | Storyboard Artist |
| Justin Brinsfield | Sound Recordist |
| Steve Daye | Storyboard Artist |
| Joe E. Elwood | Editor |
| Ernie Gilbert | Art Direction |
| Mishelle Fordham | Dialogue Editor |
| John A. Pagano | Sound Effects Editor |