 | Jerry O'Connell als Joe |
 | Megan Ward als Lily Dougherty |
 | Billy West als Ralph Roach (voice) |
 | Reginald Hudlin als Rodney Roach (voice) |
 | Willi One Blood als Complaint Handler |
 | Tracy Vilar als Complaint Handler |
 | Sandra 'Pepa' Denton als Blank |
 | Robert Vaughn als Senator Dougherty |
 | Shiek Mahmud-Bey als Vladimir Bianco |
 | Jon Spencer als Boss Hog Band Member |
 | Paul Bartel als NEA Scout |
 | Tommy Hollis als Boss Plumber |
| Don Ho als Alberto Bianco |
| Jim Sterling als Jesus Bianco / Voice of Cockroach |
 | David Huddleston als P.I. Smith |
 | Vincent Pastore als Apartment Broker #2 |
 | Scott Bigelow als Boss Construction |
 | Moby als Club DeeJay |
 | Dave Chappelle als Cockroach (voice) |
 | Godfrey als Cockroach (voice) |
 | Tim Blake Nelson als Cockroach (voice) |
 | BD Wong als Cockroach (voice) |
| Lord Kayson als Stick-Up Man #2 |
| Alex Molina als Stick-Up Man #3 |
 | Frank Bello als Stick-Up Man #1 |
 | Jim Turner als Walter Shit / Voice of Cockroach |
| Wayman Ezell als Apartment Broker #1 |
| Carter Burwell | Music |
| John Payson | Screenplay |
| John Payson | Director |
| Bonni Lee | Producer |
| Peter Deming | Director of Photography |
| Griffin Dunne | Executive Producer |
| Peter C. Frank | Editor |
| Carol Spier | Production Design |
| Karin Wiesel | Set Decoration |
| Abby Terkuhle | Executive Producer |
| Stephanie Maslansky | Costume Design |
| Patricia Regan | Makeup Artist |
| Diana Phillips | Producer |
| Ed Check | Art Direction |
| Judy McGrath | Executive Producer |
| Meg Simon | Casting |
| Nathan J. Busch II | Hairstylist |
| Michael Ringston | Assistant Camera |
| G. A. Aguilar | Stunt Coordinator |
| Randall Balsmeyer | Visual Effects Supervisor |
| Tom Bisogno | Modeling |
| Linda J. Caldwell | Digital Compositor |
| Rhett Collier | Technical Advisor |
| Richard Hadsell | Software Engineer |
| John Kahrs | Lighting Design |
| Mitch Kopelman | Senior Visual Effects Supervisor |
| Peter Kuran | Visual Effects Supervisor |
| Alexander Levenson | Modeling |
| Matt McDonald | Visual Effects |
| Nina Rappaport | Digital Effects Producer |
| Christina Reyes | Producer's Assistant |
| Sam Richards | Digital Effects Supervisor |
| John Siczewicz | Visual Effects Compositor |
| Chris Trimble | Technical Advisor |
| Michael Turoff | Visual Effects Producer |
| Leon Xiao | Systems Administrators & Support |
| Stephen Sobisky | Project Manager |
| Peter Carisi-de Lappe | Animation |
| Jan Carlee | Sequence Supervisor |
| Doug Dooley | Animation |
| David Figliola | Animation |
| Hank Liebeskind | Visual Effects |
| Marc Lougee | Animation |
| Tim Nordquist | Visual Effects Editor |
| Dan Robinson | Animation |
| Carlos Saldanha | Supervising Animation Director |
| Sean Lawrence Smith | Animation |
| Steve Talkowski | Animation |
| Aurelio Voltaire | Animation |
| Chris Wedge | Animation Director |
| William R. Wright | Visual Effects Design Consultant |
