 | Mickey Rourke als Johnny Handsome |
 | Ellen Barkin als Sunny Boyd |
 | Morgan Freeman als Lt. A.Z. Drones |
 | Forest Whitaker als Dr. Steven Fisher |
 | Elizabeth McGovern als Donna McCarty |
 | Lance Henriksen als Rafe Garrett |
 | Scott Wilson als Mikey Chalmette |
 | David Schramm als Vic Dumask |
 | Peter Jason als Mr. Bonet |
 | Yvonne Bryceland als Sister Luke |
 | Jeffrey Meek als Earl |
 | J.W. Smith als Larry |
 | Allan Graf als Bob Lemoyne |
 | Edward Walsh als Judge |
| Eugenia Ives als Nurse |
 | Blake Clark als Sheriff Monte |
 | Ken Medlock als Shipyard Accountant |
| Ed Zang als Prestige Manager |
| John P. Fertitta als Prestige Salesman |
 | Raynor Scheine als Gun Dealer |
| Gene Rudolf | Production Design |
| Ernie Bishop | Set Decoration |
| Airick Kredell | Set Decoration |
| John Godey | Author |
| Freeman A. Davies | Editor |
| Walter Hill | Director |
| Carmel Davies | Editor |
| Matthew F. Leonetti | Director of Photography |
| Charles Roven | Producer |
| Ry Cooder | Original Music Composer |
| Donn Aron | Editor |
| Christa Munro | Art Direction |
| Ken Friedman | Screenplay |
| Troy Sizemore | Art Direction |
| Dan Moore | Costume Design |
| Carline Davis-Dyer | Script Supervisor |
| Zoltan Elek | Makeup Artist |
| Bonnie Timmermann | Casting |
| Thomas A. Morris Jr. | Construction Coordinator |
| Brian Callahan | Costume Supervisor |
| Peter Tothpal | Key Hair Stylist |
| Peter Clemens | Assistant Art Director |
| Joseph P. Mercurio | Special Effects Supervisor |
| Donna Turner Culver | Hairstylist |
| Frank Viviano | Construction Coordinator |
| Mario Kassar | Executive Producer |
| Hamilton Sterling | Sound Effects Editor |
| Ted Kurdyla | Unit Production Manager |
| James Dyer | First Assistant Director |
| Barry K. Thomas | Second Assistant Director |
| Allan Graf | Second Unit Director |
| Allan Graf | Stunt Coordinator |
| Michael Westmore | Special Effects Makeup Artist |
| Noori Dehnahi | Post Production Coordinator |
| Yoko Seto | First Assistant Editor |
| Jerry Ross | Supervising Sound Editor |
| Jessica Galavan | Sound Editor |
| Hugo Weng | Sound Editor |
| Frank Smathers | Sound Editor |
| Jay Wilkinson | Sound Editor |
| Karen G. Wilson | Sound Editor |
| John Morris | Sound Editor |
| Mark Pappas | Assistant Sound Editor |
| Carolina Beroza | Assistant Sound Editor |
| Ann Ducommun | Assistant Sound Editor |
| Jim Weidman | Music Editor |
| Michael Minkler | Sound Re-Recording Mixer |
| Gregg Landaker | Sound Re-Recording Mixer |
| Eric Fitzgerald | Title Designer |
| Mae Woods | Associate Producer |
| Ted Kurdyla | Associate Producer |
| Andrew G. Vajna | Executive Producer |
| John R. Leonetti | Camera Operator |
| Michael D. Weldon | First Assistant Camera |
| Stephen J. Ullman | Second Assistant Camera |
| Richard Bryce Goodman | Sound Mixer |
| James M. McCann | Boom Operator |
| Cathy A. Roszell | Second Second Assistant Director |
| Airick Kredell | Leadman |
| John Kaufman | Set Dresser |
| Pat Blymyer | Gaffer |
| Bob Fillis | Best Boy Electric |
| Terry H. Neville | Lighting Technician |
| Robert Fiore | Lighting Technician |
| John J. Linder | Key Grip |
| Lloyd Barcroft | Best Boy Grip |
| Antonio V. Garrido | Dolly Grip |
| Johnny London Jr. | Grip |
| Alan Shultz | Grip |
| Bill Barcroft | Grip |
| Chuck E. Stewart | Special Effects |
| Wayne Edgar | Special Effects |
| Richard A. Mazzochi | Property Master |
| Ray Thomas Esteridge | Assistant Property Master |
| William D. Derham | Assistant Property Master |
| Paula Mazzochi | Assistant Property Master |
| Colby P. Bart | Costumer |
| Jo Forman | Costumer |
| Michael Germain | Makeup Artist |
| Ken Diaz | Makeup Artist |
| Peter Tothpal | Hairstylist |
| Ron Phillips | Still Photographer |
| Lloyd Leipzig | Publicist |
| Allen Tinkley | Location Manager |
| David Ross McCarty | Location Manager |
| Susan Levinson | Production Coordinator |
| Kathleen Herd | Production Coordinator |
| Patricia Graf | Production Secretary |
| Jeff Block | Casting Assistant |
| Suzanne Ryan | Casting Assistant |
| Webster Whinery | Stunts |
| John Alden | Stunts |
| Tracy Keehn-Dashnaw | Stunts |
| Gregory J. Barnett | Stunts |
| Henry Kingi | Stunts |
| Carl Ciarfalio | Stunts |
| Bill McIntosh | Stunts |
| Tim A. Davison | Stunts |
| John Sherrod | Stunts |
| Joe Finnegan | Stunts |
| Mel Scott-Thomas | Stunts |
| Lynn Fogg | Stunts |
| Andree Gibbs | Stunts |
| Richard Castleman | Extras Casting |
| Marichu Walker | Production Accountant |
| Mary L. Rand | Assistant Accountant |
| April A. Janow | Payroll Accountant |
| Steve Boyd | Transportation Coordinator |
| Maxwell R. Johnson II | Transportation Captain |
| David Elliott | Construction Foreman |
| Chris Snyder | Construction Foreman |
| George Berndt | ADR Supervisor |
| Charleen Richards-Steeves | ADR Mixer |
| Walter A. Gest | Sound Recordist |
| Robert Nichols II | Sound Recordist |
| Bob Noland | Color Timer |
| Cheryl Wheeler Duncan | Stunts |
