 | Dwayne Johnson als Dr. Smolder Bravestone |
 | Kevin Hart als Franklin 'Mouse' Finbar |
 | Jack Black als Professor Sheldon 'Shelly' Oberon |
 | Karen Gillan als Ruby Roundhouse |
 | Rhys Darby als Nigel Billingsley |
 | Bobby Cannavale als Van Pelt |
 | Nick Jonas als Jefferson 'Seaplane' McDonough |
 | Alex Wolff als Young Spencer Gilpin |
 | Ser'Darius Blain als Young Anthony 'Fridge' Johnson |
 | Madison Iseman als Young Bethany Walker |
 | Morgan Turner als Young Martha Kaply |
 | Sean Buxton als Jogger |
 | Mason Guccione als Gamer |
 | Marin Hinkle als Spencer's Mom |
 | Tracey Bonner als Fridge's Mom |
| Najah Jackson als Girl in Car |
| Natasha Charles Parker als Bethany's Mom |
| Kat Altman als Lucinda |
 | Maribeth Monroe als Teacher |
 | Missi Pyle als Coach Webb |
| Michael Shacket als Fussfeld |
| Jamie Renell als Male Gym Teacher |
 | Marc Evan Jackson als Principal Bentley |
 | Carlease Burke als Miss Mathers |
 | Jason New als Bivouac Biker |
 | Rohan Chand als Kid at Bazaar |
 | William Tokarsky als Bread Vendor |
 | Tait Fletcher als Scorpion Recipient |
 | Stephen Dunlevy als Transportation Shed Guard |
 | Rob Mars als Transportation Shed Guard |
 | Colin Hanks als Alex Vreeke (uncredited) |
 | Virginia Newcomb als Alex's Wife (uncredited) |
 | Sylvia Jefferies als Jogger's Wife (uncredited) |
 | Daniel Salyers als High School Student (uncredited) |
 | Tim Matheson als Old Man Vreeke (uncredited) |
| Tad Sallee als Skater Punk (uncredited) |
 | Ryan Baughman als Boy #1 (uncredited) |
 | Maddie Nichols als Kid #2 (uncredited) |
| Ashley Lonardo als Kid #3 (uncredited) |
 | Friday Chamberlain als Amazon Warrior (uncredited) |
| Ted Williams als Gypsy Cowboy (uncredited) |
| Juan Gaspard als The Spy (uncredited) |
 | Scott Hunter als Van Pelt's Henchman (uncredited) |
 | Maiya Boyd als Cute Bazaar Kid (uncredited) |
| Natasha Mayet als Berber Lady (uncredited) |
 | Danny Pardo als Bazaar Vendor (uncredited) |
| Jake Kasdan | Director |
| William Teitler | Producer |
| Matt Tolmach | Producer |
| Melvin Mar | Co-Producer |
| Hiram Garcia | Co-Producer |
| Ted Field | Executive Producer |
| Dany Garcia | Executive Producer |
| David B. Householter | Executive Producer |
| Dwayne Johnson | Executive Producer |
| Jake Kasdan | Executive Producer |
| Mike Weber | Executive Producer |
| Henry Jackman | Original Music Composer |
| Gyula Pados | Director of Photography |
| Chris McKenna | Screenplay |
| Erik Sommers | Screenplay |
| Scott Rosenberg | Screenplay |
| Jeff Pinkner | Screenplay |
| Chris McKenna | Screenstory |
| Chris Van Allsburg | Book |
| Steve Edwards | Editor |
| Mark Helfrich | Editor |
| Nicole Abellara Hallman | Casting |
| Jeanne McCarthy | Casting |
| Steve Cooper | Art Direction |
| Hugo Santiago | Art Direction |
| Ronald R. Reiss | Set Decoration |
| Yani Lathouris | Visual Effects |
| Jerome Chen | Visual Effects Supervisor |
| Paul Schneider | Second Assistant Director |
| Manish Raval | Music Supervisor |
| Tom Wolfe | Music Supervisor |
| Gary Hymes | Stunt Coordinator |
| Oakley Lehman | Stunt Coordinator |
| Garrett Hammond | Stunt Coordinator |
| Basil Grillo | Unit Production Manager |
| David B. Householter | Unit Production Manager |
| Matt Rebenkoff | First Assistant Director |
| Scott Puckett | Visual Effects Producer |
| Cate Hardman | Script Supervisor |
| Debra Beebe | Costume Supervisor |
| Robin Roberts | Assistant Costume Designer |
| Toni G | Makeup Department Head |
| Heather Mages | Makeup Artist |
| Merc Arceneaux | Makeup Artist |
| Roz Music | Makeup Artist |
| Vince Mountain | Set Designer |
| Stella Vaccaro | Set Designer |
| Patricia Klawonn | Set Designer |
| Jack Gill | Second Unit Director |
| Kevin O'Connell | Sound Re-Recording Mixer |
| Julian Slater | Sound Re-Recording Mixer |
| Joel Shryack | Supervising Sound Editor |
| Julian Slater | Supervising Sound Editor |
| Julian Slater | Sound Designer |
| Jon Title | Sound Designer |
| Yann Delpuech | Sound Editor |
| Shaughnessy Hare | Sound Editor |
| Jussi Tegelman | Sound Editor |
| Julia Frey | Visual Effects Producer |
| Scott Aaron Silver | Visual Effects Supervisor |
| Robert Winter | Visual Effects Supervisor |
| Anouk L'Heureux | Visual Effects Producer |
| Tom Barber | Visual Effects Producer |
| Simon Rosenthal | Visual Effects Producer |
| Ineke Majoor | Visual Effects Producer |
| Glenn Melenhorst | Visual Effects Supervisor |
| David Nelson | Visual Effects Supervisor |
| Alexandre Lafortune | Visual Effects Supervisor |
| Melanie La Rue | Visual Effects Producer |
| Sébastien Moreau | Visual Effects Producer |
| Isabelle Langlois | Visual Effects Producer |
| Jordan Soles | Visual Effects Producer |
| Marco Maldonado | Visual Effects Supervisor |
| Robin L. D'Arcy | Visual Effects Producer |
| Tim LeDoux | Visual Effects Supervisor |
| Jason Sanford | Visual Effects Producer |
| Chris Waegner | Visual Effects Supervisor |
| Joanna Bennett | Stunt Double |
| Laura Jean Shannon | Costume Designer |
| Owen Paterson | Production Designer |
| Samuel J. Paul | Stunts |
| Chick Bernhard | Stunts |
| Stephen Conroy | Stunts |
| Derek Graf | Stunts |
| Adam Horwitz | Stunts |
| Urs Inauen | Stunts |
| Tony McFarr | Stunts |
| Tim Sitarz | Stunts |
| Richard C. Taylor | Stunts |
| Michael J. Waitman | Stunts |
| Jawed El Berni | Stunts |
| Chris Denison | Stunts |
| Ryan Happy | Stunts |
| Myles Humphus | Stunts |
| Malosi Leonard | Stunts |
| Ryan Orr | Stunts |
| Greg Sproles | Stunts |
| Jacob B. Wright II | Stunts |
| Tanoai Reed | Stunts |
| Kenny Bartram | Stunts |
| David Castillo | Stunts |
| Tait Fletcher | Stunts |
| Logan Holladay | Stunts |
| Collin Hymes | Stunts |
| Jalil Jay Lynch | Stunts |
| Jimmy N. Roberts | Stunts |
| Samuel J. Paul | Stunt Double |
| Jahnel Curfman | Stunts |
| Nicolas Bosc | Stunts |
| Mark Dobson | Stunts |
| Casey Hendershot | Stunts |
| Scott Hunter | Stunts |
| Jess Lundgren | Stunts |
| Allan Padelford | Stunts |
| Aden Stay | Stunts |
| Nito Larioza | Fight Choreographer |
| Jacob B. Wright II | Stunt Double |
| Nico Woulard | Stunts |
| Jimmy Waitman | Stunt Double |
| Rich Volp | Utility Stunts |
| Hamid-Reza Benjamin Thompson | Stunts |
| Tim Soergel | Stunt Double |
| Jordan Scott | Stunt Double |
| Marc Scizak | Utility Stunts |
| Felipe Savahge | Stunt Double |
| Bayland Rippenkroeger | Stunts |
| Allan Padelford | Stunt Driver |
| Rob Mars | Stunts |
| Tony Lazzara | Stunts |
| Hiro Koda | Utility Stunts |
| Myles Humphus | Stunt Double |
| Logan Holladay | Stunt Double |
| Jason Charles Hill | Stunt Driver |
| Shane Habberstad | Stunt Double |
| Tad Griffith | Stunts |
| Victor Favrin | Stunts |
| Tim Drnec | Utility Stunts |
| Craig H. Davidson | Utility Stunts |
| Tom Crisp | Utility Stunts |
| Duane Burkhart | Utility Stunts |
| Rico Burgos | Utility Stunts |
| Chelsea Bruland | Stunts |
| Damien Bray | Utility Stunts |
| Chris Barrett | Stunts |
| Ashlen Aquila | Utility Stunts |
| Doug Delaney | Digital Intermediate Colorist |
| Brian Webb | Extras Casting Assistant |
| Chris Velez | Casting Associate |
| Toni Avalos | Extras Casting |
| Blossom Peters | Extras Casting Assistant |
| Rick Messina | Casting Associate |
| George Ludlow | Casting Coordinator |
| Meagan Lewis | Location Casting |
| Ashley Lambert | ADR Voice Casting |
| Alyssa Jacobson | Extras Casting |
| Mary Huber | Extras Casting |
| Katie Doyle | Location Casting |
| Alexandra Di Giacomo | Extras Casting Assistant |
| Hannah Caruso | Casting Assistant |
| Debbie Andrews | Casting |
| Greg Taylor | Original Film Writer |
| Chris Van Allsburg | Original Film Writer |
| Jonathan Hensleigh | Original Film Writer |
| Jim Strain | Original Film Writer |
