 | Wesley Snipes als Flipper Purify |
 | Annabella Sciorra als Angie Tucci |
 | Spike Lee als Cyrus |
 | Ossie Davis als Reverend Purify |
 | Ruby Dee als Lucinda Purify |
 | Samuel L. Jackson als Gator Purify |
 | Lonette McKee als Drew |
 | John Turturro als Pauline Carbone |
 | Frank Vincent als Mike Tucci |
 | Anthony Quinn als Lou Carbone |
 | Halle Berry als Vivian |
 | Tyra Ferrell als Orin Goode |
 | Veronica Webb als Vera |
 | Veronica Timbers als Ming |
 | David Dundara als Charlie Tucci |
 | Michael Imperioli als James Tucci |
 | Nicholas Turturro als Vinny |
 | Steven Randazzo als Sonny |
 | Joseph D'Onofrio als Patty |
 | Michael Badalucco als Frankie Botz |
| Anthony Nocerino als Veeshay |
 | Debi Mazar als Denise |
 | Gina Mastrogiacomo als Louise |
 | Tim Robbins als Jerry |
 | Brad Dourif als Leslie |
 | Phyllis Yvonne Stickney als Nilda |
 | Theresa Randle als Inez |
| Pamala Tyson als Angela |
 | Rick Aiello als Officer Long |
 | Miguel Sandoval als Officer Ponte |
 | Charlie Murphy als Livin' Large |
| Talese Harris als Iris |
| Averell Curtle als Young Panhandler |
| Melvin Bethea als Drug Dealer |
| Ewart Lauder als Drug Dealer |
| Randolph May als Man in Crack Den |
| El-Shah Muhammad als Gentleman in Wheelchair |
| Suzanna White als Church Lady |
| Danielle Coleman als Woman Panhandler |
| Marilyn Nelson als Crack Lady |
 | Bob Adrian als Man on the Street |
 | Doug E. Doug als Friend of Livin' Large |
 | Scot Anthony Robinson als 2nd Friend of Livin' Large |
| Frank Esposito als Frankie, Denise's Brother |
| Joseph Giammarino als Boy in Candy Store |
| Shawn Lowenthal als 2nd Boy in Candy Store |
 | Queen Latifah als Lashawn |
| Curtis Atkins als Paperboy |
| Yvette Brooks als Mouth #1 |
| Mamie Louise Anderson als Mouth #2 |
| Wynn Thomas | Production Design |
| Jon Kilik | Line Producer |
| Spike Lee | Director |
| Spike Lee | Producer |
| Spike Lee | Writer |
| Terence Blanchard | Original Music Composer |
| David Boulton | ADR Recordist |
| Skip Lievsay | Sound Designer |
| Magdaline Volaitis | Dialogue Editor |
| Ernest R. Dickerson | Director of Photography |
| Robi Reed | Casting |
| Ruth E. Carter | Costume Design |
| Larry M. Cherry | Hairdresser |
| Alex Steyermark | Music Editor |
| Stevie Wonder | Original Music Composer |
| Sam Pollard | Editor |
| Ted Glass | Set Decoration |
| Russell Williams II | Sound Recordist |
| Ellie Winslow | Makeup Artist |
| Pamela Katz | First Assistant Camera |
| Frank Prinzi | Additional Camera |
| Preston L. Holmes | Production Supervisor |
| Ron Bochar | Sound Effects Editor |
| Marko Costanzo | Foley Artist |
| Chris Fielder | Assistant Sound Editor |
| Ted Churchill | Steadicam Operator |
| Scott Rosenstock | Leadman |
| Fred Rosenberg | Dialogue Editor |
| Bernadette Mazur | Makeup Artist |
| Jeff Balsmeyer | Storyboard Artist |
| Tracy Vilar | Extras Casting |
| H.H. Cooper | Second Assistant Director |
| Jeffrey Stern | Dialogue Editor |
| Brian Johnson | Assistant Sound Editor |
| Brent Owens | Location Manager |
| Brent Owens | Unit Manager |
| Monty Ross | Co-Producer |
| Larry McConkey | Steadicam Operator |
| Phil Oetiker | Camera Operator |
| George Pattison | Additional Camera |
| Jeff Ward | Stunt Coordinator |
| Frank Kern | Foley Editor |
| Robert M. Andres | Key Grip |
| Kevin Ladson | Property Master |
| Albert Aquino | Boom Operator |
| Martin Bernstein | Construction Coordinator |
| Tom Fleischman | Sound Re-Recording Mixer |
| Kirk R. Gardner | Steadicam Operator |
| Deborah Wallach | ADR Editor |
| Laini Thompson | Makeup Artist |
| Brunilda Torres | Additional Editor |
| Shari L. Carpenter | Continuity |
| Diann Duthie | Assistant Art Director |
| David Lee | Still Photographer |
| Jennifer Bryan | Wardrobe Supervisor |
| Steven Visscher | Foley Editor |
| Clifford Booker | Hairdresser |
| Pam DeMetruis-Thomas | ADR Editor |
| Randy Fletcher | First Assistant Director |
| Bruce Pross | Foley Editor |
| Kevin Lee | Dialogue Editor |
| Eric Klein | Assistant Location Manager |
| Andrea Reed | Extras Casting |
| Susan D. Fowler | Production Coordinator |
| Paul Wachter | Best Boy Grip |
| Dale Pierce-Johnson | Second Assistant Director |
| Debra D. Jeffreys | Production Office Coordinator |
| Anna Southall | Unit Publicist |
| Sherri G. Sneed | Production Secretary |
| Daniel Sanabria | First Assistant Camera |
| Floyd A.B. Rance III | Second Assistant Camera |
| Nate Ranger | Second Assistant Camera |
| Charles Houston | Gaffer |
| Val DeSalvo | Best Boy Electric |
| Tom Kudlek | Dolly Grip |
| Carl Anthony Lee | Casting Associate |
| Dale Watkins | Assistant Location Manager |
| Leander T. Sales | Assistant Editor |
| Diane Schaub | ADR Editor |
| Greg Speed | Assistant Sound Editor |
| James Leavey | Transportation Captain |
