 | Tracy Pollan als Beth Holloway |
 | Stephen Amell als Joran Van Der Sloot |
 | Scott Cohen als John Q. Kelly |
 | Amy Gumenick als Natalee Holloway |
 | Michael Beach als Agent Delaney |
 | Francesco Quinn als Ricardo Flores |
 | Julio Oscar Mechoso als Det. Martinez |
 | Melissa Ponzio als Debra Stanville |
 | Grant Show als Jug Twitty |
 | Sari Cummings als Thai dancer |
 | Silas Cooper als FBI Agent |
| Teena Booth | Writer |
| Stephen T. Kay | Director |
| Kati Johnston | Producer |
| Jamie Barber | Director of Photography |
| Tree Adams | Original Music Composer |
| Frank J. Zito III | Art Direction |
| Jessica Harrison | Music Editor |
| Paul Blanchard | Set Decoration |
| Rickley W. Dumm | Sound Effects Editor |
| Tad Seaborn | Editor |
| Mark Hava | Special Effects Coordinator |
| Susan Edelman | Casting |
| Anthony Medina | Production Design |
| Tracy Ewell | Key Makeup Artist |
| Lauren Pendergrass | Editor |
| Jeff Galpin | Stunt Coordinator |
| Maria Senger | Art Department Coordinator |
| Eduardo Castro | Costume Design |
| Donna Spahn | Hair Department Head |
| Craig Fincannon | Casting |
| Susan Spaid | Makeup Department Head |
| Adam Ward | Steadicam Operator |
| Mark Lanza | Sound Effects Editor |
| Ron Uribe | Production Coordinator |
| Handel Whitmore | First Assistant Director |
| Jennifer J. Collins | Script Supervisor |
| Judith Verno | Executive Producer |
| Frank von Zerneck | Executive Producer |
| Stephen T. Kay | Co-Executive Producer |
| Fritzi Horstman | Associate Producer |