 | Jeff Bridges als Dr. Mark Powell |
 | Kevin Spacey als Prot |
 | Mary McCormack als Rachel Powell |
 | Alfre Woodard als Claudia Villars |
 | Ajay Naidu als Dr. Chakaraborty |
 | Vincent Laresca als Navarro |
 | Kimberly Scott als Joyce Trexler |
 | Conchata Ferrell als Betty McAllister |
 | Saul Williams als Ernie |
 | Peter Gerety als Sal |
 | David Patrick Kelly als Howie |
 | Melanee Murray als Bess |
 | Celia Weston als Mrs. Archer |
 | Brian Howe als Steve Becker |
| Greg Lewis als Dominic McAllister |
 | John Toles-Bey als Russell |
 | Mark Christopher Lawrence als Simms |
 | Mary Mara als Abby |
| Brandon de Paul als Josh - Age 10 |
| Tess McCarthy als Natalie Powell - Age 6 |
| Natasha Dorfhuber als Gabby Powell - Age 9 |
 | Aaron Paul als Michael Powell - Age 21 |
 | William Lucking als Sheriff |
| Zofia Borucka als Woman on Train |
 | Curt Clendenin als Hospital Patient (uncredited) |
 | Frank Collison als Screaming Man (uncredited) |
| Moet Meira als Jennifer (uncredited) |
 | Peter Maloney als Duncan Flynn |
 | Lance E. Nichols als David Patel |
 | Erik LaRay Harvey als Security Guard |
 | Paulo Pascoal als Thief (Uncredited) |
 | Tracy Vilar als Maria |
| Iain Softley | Director |
| Lawrence Gordon | Producer |
| Lloyd Levin | Producer |
| Robert F. Colesberry | Producer |
| Susan G. Pollock | Executive Producer |
| Charles Leavitt | Screenplay |
| Gene Brewer | Novel |
| Ed Shearmur | Original Music Composer |
| John Mathieson | Director of Photography |
| Craig McKay | Editor |
| Debra Zane | Casting |
| Louise Mingenbach | Costume Design |
| John Beard | Production Design |
| Alec Hammond | Art Direction |
| Cheryl Carasik | Set Decoration |
| Richard Bloom | Art Department Coordinator |
| Drew Boughton | Assistant Art Director |
| Dave DeGaetano | Construction Coordinator |
| Paul J. Lombardi | Special Effects Coordinator |
| Daniel Robichaud | CGI Supervisor |
| Petra Holtorf | Visual Effects Producer |
| Conny Fauser | Visual Effects Supervisor |
| Terri Taylor | Casting Associate |
| Pamela Wise | Costume Supervisor |
| Jill E. Anderson | Costume Supervisor |
| Barbara Hause | Costume Supervisor |
| Patricia Bercsi | Set Costumer |
| Amanda Gore | Set Costumer |
| Kathleen Gore-Misko | Set Costumer |
| Emily Wyss | Set Costumer |
| Daryl B. Kell | Music Editor |
| Karen Golden | Script Supervisor |
| Martin Samuel | Hair Department Head |
| Susan Germaine | Hairstylist |
| Sterfon Demings | Hairstylist |
| Carol A. O'Connell | Hairstylist |
| John Quaglia | Key Hair Stylist |
| Rod Ortega | Key Hair Stylist |
| Teresa M. Austin | Makeup Department Head |
| Pamela Santori | Makeup Artist |
| Tania McComas | Makeup Artist |
| Lori Hicks | Makeup Artist |
| Edouard F. Henriques | Makeup Artist |
| Paul C. Babin | Camera Operator |
| Jim McConkey | Steadicam Operator |
| Andy Shuttleworth | Steadicam Operator |
| Suzanne Tenner | Still Photographer |
| Jimmy Keys | Rigging Gaffer |
| Tim Alatorre | Rigging Grip |
| Bret Rubin | Rigging Grip |
| Mark R. Rubin | Rigging Grip |
| Justin Van Fleet | Rigging Grip |
| Spencer Wilcox | Rigging Grip |
| Matt Cohen | 24 Frame Playback |
| Tim Rigby | Stunts |
| Keii Johnston | Stunt Coordinator |
| Patrick J. Foley | Dialogue Editor |
| Douglas T. Madison | Property Master |
| John F. Reynolds | Dialogue Editor |
| Michael Levy | Co-Producer |
| Joey Box | Stunt Coordinator |
| Jery Hewitt | Stunt Coordinator |
| Richard Burden | Stunts |
| Tim Gilbert | Stunts |
| Jennifer Lamb | Stunts |
| Phil Culotta | Stunts |
| Harry O'Connor | Stunts |
| Jim Palmer | Stunts |
| Loyd Catlett | Stunt Double |
| Robert F. Colesberry | Unit Production Manager |
| Peter Kohn | First Assistant Director |
| Scott Robertson | Second Assistant Director |
| Gene Brewer | Associate Producer |
| Carl S. Griffin | Production Supervisor |
| Deirdre Slevin | Associate Editor |
| Mark Poll | Set Designer |
| David M. Dunlap | "B" Camera Operator |
| Michael St. Hilaire | "B" Camera Operator |
| Michael G. Riba | First Assistant Camera |
| Christos Bitsakos | Second Assistant Camera |
| Camille Freer | Additional Second Assistant Camera |
| Michael R. Marquette | First Assistant "C" Camera |
| Gary Dunham | First Assistant "B" Camera |
| Marta Weiss | Second Assistant "B" Camera |
| Mark Weingarten | Production Sound Mixer |
| Jeff Erdmann | Boom Operator |
| Jeff Enden | Boom Operator |
| Craig Raiche | Assistant Property Master |
| Diane Ward | Production Coordinator |
| James B. Crawford | Chief Lighting Technician |
| Scott Kidner | Assistant Chief Lighting Technician |
| Jeff Case | Key Grip |
| Lisa Rodgers | Post Production Supervisor |
| Joe Landauer | First Assistant Editor |
| Chris Furia | Production Accountant |
| Ernest M. Sanchez | Leadman |
| Jessica Drake | Dialect Coach |
| Chris Jenkins | Sound Re-Recording Mixer |
| Frank A. Montaño | Sound Re-Recording Mixer |
| Rick Kline | Sound Re-Recording Mixer |
| J. Paul Huntsman | Supervising Sound Editor |
| Barbara Harris | ADR Voice Casting |
| David Lee Fein | Foley Artist |
| Pamela Kahn | Foley Artist |
| David Jobe | Foley Mixer |
| Gary Burritt | Negative Cutter |
| Dale E. Grahn | Color Timer |
