 | Kevin Hart als George Beard (voice) |
 | Thomas Middleditch als Harold Hutchins (voice) |
 | Ed Helms als Mr. Krupp / Captain Underpants (voice) |
 | Nick Kroll als Professor Poopypants (voice) |
 | Jordan Peele als Melvin (voice) |
 | Kristen Schaal als Edith (voice) |
 | DeeDee Rescher als Ms. Ribble (voice) |
 | Brian Posehn als Mr. Rected (voice) |
 | David Soren als Tommy (voice) |
 | Mel Rodriguez als Mr. Fyde (voice) |
 | Susan Fitzker als Ms. Dayken (voice) |
 | Lynnanne Zager als George's Mom (voice) |
 | Tiffany Lauren Bennicke als Sad Girl (voice) |
 | James Ryan als Mime (voice) |
 | Leslie David Baker als Officer McPiggly (voice) |
 | Sugar Lyn Beard als Goodie Two-Shoes Girl (voice) |
 | Lesley Nicol als Nobel Moderator (voice) |
 | Chris Miller als Nobel Audience Member (voice) |
| Coco Soren als Balloon Girl (voice) |
| David Soren | Director |
| Rob Letterman | Executive Producer |
| Mark Swift | Producer |
| Thibault Bunoust | Lighting Artist |
| Tighe Sheldon | ADR & Dubbing |
| Luiza Alaniz | Animation |
| Woosuk Jung | Animation |
| Sebastien Bruneau | Animation Director |
| Christophe Duflaut | Lighting Artist |
| David Yanover | Post-Production Manager |
| Angie Howard | Production Manager |
| Chris Fogel | Scoring Mixer |
| Chris Finnegan | Producer |
| Jeanne McCarthy | Casting |
| Ian Allard | Lighting Artist |
| Michelle Mendenhall | Additional Editing |
| Thibault Hormiere | Animation |
| Rune Brandt Bennicke | Character Designer |
| Jason Stovall | Compositors |
| Jay Bixsen | First Assistant Editor |
| Dorina Markoff-McNulty | Musician |
| David Hail | Publicist |
| Chris Diebold | Sound Effects Editor |
| Erik Tillmans | 2D Supervisor |
| David Lapierre | Animation |
| Marie Balland | Line Producer |
| Grant Wilson | Animation |
| Omar El Hindi | Animation |
| Brian Hopkins | Associate Editor |
| Susan Fitzer | Additional Editing |
| Patrick Cicero | Foley Editor |
| Frédéric Côté | Lead Animator |
| Thanos Kousis | Animation |
| James Beshears | Executive In Charge Of Post Production |
| Randy Kerber | Orchestrator |
| Joanna Lynne Smith | Production Coordinator |
| Mike Mitchell | Thanks |
| Philippe Zerounian | Lead Animator |
| Raymond Zibach | Thanks |
| Kim Nieva | Music Supervisor |
| Mark Deimel | Additional Editing |
| Gabrielle Dion-Fortin | Assistant Editor |
| Sheri Galloway | Assistant Editor |
| Brandon Taylor | Digital Compositors |
| Steve Ouellette | Digital Compositors |
| Jean-François Barthélémy | Lead Animator |
| Conrad Vernon | Thanks |
| Michael McCullers | Thanks |
| Roy Latham | ADR & Dubbing |
| Gabriel Bégin | Animation |
| Jessica Gibbons | Animation |
| Lucie Lavergne | Lighting Artist |
| Nate Wragg | Production Design |
| Brune Marie de Miscault | Lighting Artist |
| Adam Trout | Animation |
| David Rouxel | Animation |
| Eric Lambert | Animation |
| Jonathan Philippon | Animation |
| Martin Ferland | Animation |
| Tanguy Gourret | Animation |
| Richard Ramazinski | Compositors |
| Damien Simonklein | Production Manager |
| Nicole Abellara Hallman | Casting |
| Shibo Xiao | Lighting Artist |
| Bruno Etchepare | Animation |
| Ki Eun Suh | Animation |
| Nicola Sterpone | Animation |
| Mollie Gamo | Casting Associate |
| Thomas S. Drescher | Music Editor |
| James Thatcher | Musician |
| Chad Hammes | Thanks |
| Leslee Feldman | Casting |
| Matt Landon | Editor |
| Kelly M. Covey | Script Coordinator |
| Benoît Gautier | Animation |
| Mark Graham | Conductor |
| Will Erokan | First Assistant Editor |
| Taran Matharu | Lead Animator |
| R.J. Peña | Lighting Artist |
| Jeff Sawyer | Sound Effects Editor |
| Jeffrey Katzenberg | Thanks |
| Claire Deberle | Animation |
| David Ward | Animation |
| Dimitrios Aspros | Animation |
| Boizanté Guillaume | Lighting Artist |
| Steve Mair | Musician |
| Katherine Ramos | Production Supervisor |
| Eddie Hession | Musician |
| Jacques Desanlis | Lighting Artist |
| William J. Caparella | Additional Editing |
| Catherine Harper | Foley |
| John Ashton Thomas | Orchestrator |
| Steve Jamerson | Sound Engineer |
| Cory Walker | Systems Administrators & Support |
| Alice Martin | Thanks |
| Kassie Evashevski | Thanks |
| Mireille Soria | Producer |
| Chloé Proulx | Animation |
| Erik Tillmans | Animation |
| Ryan Cummins | Compositors |
| Jean Hemez | Lead Animator |
| Christy Page | Lighting Artist |
| Matt Chamberlain | Musician |
| Michael Babcock | Sound Re-Recording Mixer |
| Anna Gopin | Animation |
| Jennifer Gustafson | Animation |
| Lang-Willar Chloe | Animation |
| Renaud Mégange | Animation |
| Boris Plateau | Lead Animator |
| Ann Daly | Thanks |
| Jonathan Navarro | Lighting Artist |
| Michael Babcock | Sound Designer |
| Samy Fecih | Lead Animator |
| Kevin Connolly | Musician |
| Ade Macalinao | Production Coordinator |
| Emily Nordwind | Production Manager |
| Amy Berkower | Thanks |
| Gregg Taylor | Thanks |
| James Ryan | Thanks |
| Mette Tange | Animation |
| Jason Bone | Character Designer |
| Mary Melendez | Production Supervisor |
| Edward Cervenka | Musician |
| Christi Soper Hilt | Casting |
| Michael Babcock | Supervising Sound Editor |
| Dorian Bougard | Animation |
| Jordi Gaspar Aldea | Animation |
| Kevin Herron | Animation |
| Maxence Verniers-Diers | Animation |
| Dav Pilkey | Executive Producer |
| Michael P. Hamler | Master Lighting Artist |
| Anthony Falcon | Music Supervisor |
| Anamika Bhatnagar | Thanks |
| Anthony Fung | VFX Artist |
| Dana Robins | VFX Artist |
| Ashley-Martin Dunn | VFX Artist |
| Tom McGrath | Thanks |
| Perry Maple | Visual Development |
| Stephen Mallia | VFX Artist |
| Walt Dohrn | Thanks |
| David Dulac | VFX Supervisor |
| Sayuri Pilkey | Thanks |
| Floriane Marchix | Visual Development |
| Damon O'Beirne | Head of Layout |
| David Dulac | Visual Effects Supervisor |
| Damon O'Beirne | Cinematography |
| David Soren | Additional Writing |
| Nicholas Stoller | Screenplay |
| Dav Pilkey | Novel |
| Theodore Shapiro | Original Music Composer |
| 'Weird Al' Yankovic | Theme Song Performance |
| Hamish Grieve | Head of Story |
| Adam Anders | Executive Music Producer |
