 | Franco Nero als Keoma |
 | William Berger als William Shannon |
 | Olga Karlatos als Lisa |
 | Orso Maria Guerrini als Butch |
 | Gabriella Giacobbe als The Witch |
 | Antonio Marsina als Lenny |
 | Joshua Sinclair als Sam Shannon |
 | Woody Strode als George |
 | Donald O'Brien als Caldwell |
 | Wolfango Soldati als Caldwell Lead Henchman |
 | Victoria Zinny als Brothel Owner |
 | Alfio Caltabiano als Member of Caldwell's Gang |
 | Leonardo Scavino als Dokter |
| Pierangelo Civera als Plague Victim |
 | Giovanni Cianfriglia als Gang Member |
 | Armando Bottin als Member of Caldwell's Gang |
 | Roberto Dell'Acqua als Member of Caldwell's Gang |
| Franco Ukmar als Member of Caldwell's Gang |
 | Riccardo Pizzuti als Member of Caldwell's Gang |
 | Riccardo Petrazzi als Member of Caldwell's Gang |
 | Angelo Ragusa als Member of Caldwell's Gang |
 | Massimo Vanni als Man Shot off Horse |
 | Sergio Ukmar als Member of Caldwell's Gang |
| Sergio Ruggeri als Man Shot in Saloon |
 | Augusto Funari als Member of Caldwell's Gang (uncredited) |
 | Osiride Pevarello als Member of Caldwell's Gang (uncredited) |
 | Domenico Cianfriglia als Member of Caldwell's Gang (uncredited) |
 | Giovanni Bonadonna als Member of Caldwell's Gang (uncredited) |
 | Attilio Severini als Member of Caldwell's Gang (uncredited) |
| Sergio Ukmar als Member of Caldwell's Gang (uncredited) |
| Giancarlo Ukmar als Member of Caldwell's Gang (uncredited) |
| Angelo Ragusa als Member of Caldwell's Gang (uncredited) |
| Antonio Basile als Member of Caldwell's Gang (uncredited) |
 | Roberto Messina als Member of Caldwell's Gang (uncredited) |
| Aldo Canti als Member of Caldwell's Gang (uncredited) |
 | Catharina Dahlin als Woman Receiving Medicine (uncredited) |
 | Giglio Gigli als Member of Caldwell's Gang (uncredited) |
 | Giovanni Ukmar als Member of Caldwell's Gang (uncredited) |
 | Clemente Ukmar als Member of Caldwell's Gang (uncredited) |
| Matteo Zoffoli als Young Butch (uncredited) |
| Enzo G. Castellari | Director |
| Enzo G. Castellari | Screenplay |
| Mino Roli | Screenplay |
| Aiace Parolin | Director of Photography |
| Maurizio De Angelis | Original Music Composer |
| Gianfranco Amicucci | Editor |
| Nico Ducci | Screenplay |
| Manolo Bolognini | Producer |
| Carlo Simi | Production Design |
| Guido De Angelis | Original Music Composer |
| George Eastman | Screenplay |
| Giovanni Bergamini | Camera Operator |
| Rocco Lerro | First Assistant Director |
| Rocco Lerro | Master at Arms |
| George Eastman | Story |
| Carlo Simi | Costume Design |
| Stefano Pegoraro | Production Manager |
| Carlo Giovagnorio | Unit Manager |
| Vivalda Vigorelli | Script Supervisor |
| Alfonso Gola | Makeup Artist |
| Giusy Bovino | Hairstylist |
| Maurizio Cipriani | Assistant Camera |
| Massimo Carta | Assistant Camera |
| Carlo Gentili | Set Decoration |
| Bernardino Fronzetti | Sound |
| Benito Alchimede | Boom Operator |
| Gilberto Provenghi | Assistant Makeup Artist |
| Ermanno Serto | Still Photographer |
| Nicolò Forte | Production Secretary |
| Cesarina Casini | Assistant Editor |
| Roberto Amicucci | Assistant Editor |
| Guglielmo Maga | Key Grip |
| Bruno Pasqualini | Gaffer |
| Giovanni Corridori | Special Effects |
| Tonino Cacciottolo | Sound Effects |
| Gianni D'Amico | Sound Mixer |
