 | Dave Foley als Marv / Psychiatrist / New guy / Raymond Hurdicure |
 | Bruce McCulloch als Alice / Cisco / Grivo / Worm pill scientist / Cop #2 / Cancer boy / White-trash man |
 | Kevin McDonald als Dr. Chris Cooper / Doreen / Chris' dad / Lacey |
 | Mark McKinney als Simon / Don Roritor / Cabbie / Gunther / Cop #1 / Nina Bedford / Melanie / Drill sergeant / White-trash woman |
 | Scott Thompson als Baxter / Mrs. Hurdicure / Wally Terzinsky / Malek / Big Stummies scientist / The Queen / Raj / Clemptor |
 | Kathryn Greenwood als Ginny Hurdicure |
 | Nicole de Boer als Cooper's Groupie |
 | Krista Bridges als Cooper's Groupie |
 | Christopher Redman als Wally Jr. |
 | Sherry Hilliard als Coma Queen |
 | Brendan Fraser als Placebo Patient |
 | Janeane Garofalo als Woman at Party |
 | Lindsay Leese als Scientist |
| Kirsten Johnson als Scientist |
 | Jackie Harris Greenberg als Natalie |
| Erica Fairfield als Wally's Daughter |
| Tom Rosenberg | Executive Producer |
| Richard S. Wright | Producer |
| Sigurjón Sighvatsson | Executive Producer |
| Barnaby Thompson | Producer |
| Andy Malcolm | Foley |
| Ross Clydesdale | Casting |
| Paul D. Austerberry | Art Direction |
| Lorne Michaels | Producer |
| Mark McKinney | Writer |
| Kevin McDonald | Writer |
| David A. Makin | Director of Photography |
| Kelly Makin | Director |
| David Steinberg | Executive Producer |
| Bruce McCulloch | Writer |
| Scott Thompson | Writer |
| Christopher Cooper | Editor |
| Craig Northey | Original Music Composer |
| Martin Walters | Line Producer |
| Gregory P. Keen | Production Design |
| Norm Hiscock | Writer |
| Pat Steward | Original Music Composer |
| Peter Melnychuk | Boom Operator |
| Robert McRae | Gaffer |
| Keith Elliott | Sound Re-Recording Mixer |
| Kathryn Buck | Script Supervisor |
