 | Christy Carlson Romano als Kim Possible (voice) |
 | Will Friedle als Ron Stoppable (voice) |
 | Nancy Cartwright als Rufus (voice) |
 | Tahj Mowry als Wade (voice) |
 | Mayim Bialik als Justine Flanner (voice) |
 | Gary Cole als Dr. Possible (voice) |
 | John DiMaggio als Dr. Drakken (voice) |
 | Shaun Fleming als Jim Possible / Tim Possible (voice) |
 | Rob Paulsen als Hank Perkins (voice) |
 | Brian George als Duff Killigan (voice) |
 | Tom Kane als Monkey Fist (voice) |
 | Kerri Kenney als Additional Voices (voice) |
 | Melissa McCarthy als Amy Hall (voice) |
 | Jean Smart als Dr. Ann Possible (voice) |
 | Kirsten Storms als Bonnie Rockwaller (voice) |
 | Nicole Sullivan als Shego (voice) |
 | Raven-Symoné als Monique (voice) |
 | Patrick Warburton als Steve Barkin (voice) |
 | Gedde Watanabe als Professor Bob Chen (voice) |
 | Jo Anne Worley als Additional Voices (voice) |
 | Frank Welker als Professor Otto Allenford (voice) |
 | Diedrich Bader als Lars (voice; uncredited) |
 | Eddie Deezen als Ned (voice; uncredited) |
 | Clyde Kusatsu als Nakasumi (voice; uncredited) |
 | Maurice LaMarche als 'Big Daddy' Brotherson (voice; uncredited) |
 | Phil LaMarr als Ninja / Japanese Businessman #2 (voice; uncredited) |
 | Kevin Michael Richardson als Sumo Ninja / Dr. Gooberman / Businessman (voice; uncredited) |
 | Stephen Root als Cowboy Gambler (voice; uncredited) |
 | Rider Strong als Brick Flagg (voice; uncredited) |
 | Tara Strong als Computer (voice; uncredited) |
 | Lauren Tom als Yoshiko (voice; uncredited) |
 | Ricky Ullman als Eric (voice; uncredited) |
 | April Winchell als Reporter (voice; uncredited) |
| Mark McCorkle | Writer |
| Bob Schooley | Writer |
| Mark McCorkle | Creator |
| Bob Schooley | Creator |
| Chris Bailey | Director |
| David Block | Director |
| Chris Bailey | Executive Producer |
| Mark McCorkle | Executive Producer |
| Bob Schooley | Executive Producer |
| Mark McCorkle | Story Editor |
| Madellaine Paxson | Story Editor |
| Bob Schooley | Story Editor |
| Gary Sperling | Story Editor |
| Madellaine Paxson | Writer |
| Gary Sperling | Writer |
| Brian Swenlin | Writer |
| Adam Berry | Original Music Composer |
| Christopher K. Gee | Editor |
| John Royer | Editor |
| Chris Bailey | Dialogue Coach |
| Lisa Schaffer | Dialogue Coach |
| Lisa Schaffer | Casting |
| Jamie Thomason | Casting |
| Troy Adomitis | Storyboard |
| Nick Filippi | Story Supervisor |
| Tom Bernardo | Storyboard |
| Barry Caldwell | Storyboard |
| Louie del Carmen | Storyboard |
| Chris Rutkowski | Storyboard |
| Eugene Salandra | Storyboard |
| Barbara Dourmaskin-Case | Other |
| Patrick Gleeson | Other |
| J.K. Kim | Other |
| Marsh Lamore | Other |
| Rick Leon | Other |
| Michel Lyman | Other |
| Kevin Petrilak | Other |
| Bob Zamboni | Other |
| Kurt Weldon | Line Producer |
| Alan Bodner | Art Direction |
| Stephen Silver | Lead Character Designer |
| Brent Gordon | Character Designer |
| Eugene Salandra | Character Designer |
| Ernie Guanlao | Prop Designer |
| Scott Hill | Prop Designer |
| Jason Hulst | Prop Designer |
| Alex McCrae | Background Designer |
| Andrew Ice | Background Designer |
| Bruce Berkey | Background Designer |
| Lou Police | Background Designer |
| Justin K. Thompson | Background Designer |
| Teri Shikasho | Background Designer |
| Sy Thomas | Background Designer |
| Nadia Vurbenova | Background Designer |
| Karen Kilpatrick | Color Designer |
| Nancy Ulene | Color Designer |
| Dave DiMatteo | Color Grading |
| Celeste Moreno | Other |
| Eugene Salandra | Other |
| Zac Moncrief | Storyboard Artist |
| John Nevarez | Storyboard Artist |
| Chris Rutkowski | Storyboard Artist |
| Calvin Suggs | Storyboard Artist |
| Bong Hee Han | Animation Director |
