 | Mel Gibson als Martin Riggs |
 | Danny Glover als Roger Murtaugh |
 | Joe Pesci als Leo Getz |
 | Rene Russo als Lorna Cole |
 | Stuart Wilson als Jack Travis |
 | Steve Kahan als Captain Ed Murphy |
 | Mary Ellen Trainor als Stephanie Woods |
 | Darlene Love als Trish Murtaugh |
 | Traci Wolfe als Rianne Murtaugh |
 | Ebonie Smith als Carrie Murtaugh |
 | Damon Hines als Nick Murtaugh |
 | Thomas A. Geas als Man at Hamburger Stand |
| Gregory Millar als Tyrone |
 | Nick Chinlund als Hatchett |
 | Alan Scarfe als Herman Walters |
 | Delores Hall als Delores |
 | Mark Pellegrino als Billy Phelps |
 | John Cenatiempo als Smitty |
 | Pete Antico als Henchman #1 / Hubie |
 | Sven-Ole Thorsen als Henchman #2 |
 | Paul Tuerpe als Henchman #3 |
 | Veronica Alicino als Squad Member #1 (as Ronnie Alicino) |
 | Miguel A. Núñez Jr. als Squad Member #4 (as Miguel Nunez) |
 | Philip Moon als Squad Member #5 |
 | Vince Howard als Preacher (as Vincent Howard) |
 | Paul Hipp als Doctor |
 | Lauren Shuler Donner als Nurse (as Lauren Shuler-Donner) |
 | Marian Collier als Patron |
 | James Oliver als Manager |
 | Jan de Bont als Dutch Cameraman (uncredited) |
 | Mic Rodgers als Bomb Scene Cop #1 (uncredited) |
 | Stephen T. Kay als Movie Director |
 | Norman D. Wilson als Fast Eddie |
 | Anthony Johnson als Drug Dealer |
| Jason Rainwater als Officer Chuck Edwards |
 | J. Mills Goodloe als Harbormaster |
 | Jack McGee als Carpenter (uncredited) |
| Michael Klastorin als CDR Worker |
| Richard C. Goddard | Set Decoration |
| Richard Donner | Producer |
| Jeffrey Boam | Screenplay |
| Marion Dougherty | Casting |
| Greg Papalia | Art Direction |
| Joel Silver | Producer |
| Jan de Bont | Director of Photography |
| Robert Mark Kamen | Screenplay |
| Robert Brown | Editor |
| David Sanborn | Original Music Composer |
| James H. Spencer | Production Design |
| Eric Clapton | Original Music Composer |
| Michael Kamen | Original Music Composer |
| Richard Donner | Director |
| Battle Davis | Editor |
| Mark Poll | Set Designer |
| Jennie Lew Tugend | Co-Producer |
| Ciro Vuoso | Construction Foreman |
| John Schacht | Leadman |
| Lonnie Craig | Driver |
| James Grayford | Stand In |
| Matt Sweeney | Special Effects Supervisor |
| Paul Abascal | Key Hair Stylist |
| Richard Snell | Makeup Artist |
| Dan Romero | Transportation Captain |
| Jack Lietzke | Transportation Coordinator |
| Owens Hill | Casting Associate |
| Michael Muscarella | Construction Coordinator |
| Cary Conway | Painter |
| J. Neil Bloomer | Grip |
| Steve Perry | Unit Production Manager |
| Michael Klastorin | Associate Producer |
| Calmar Roberts | First Assistant Camera |
| Gregory Lundsgaard | Steadicam Operator |
| Geno Escarrega | Post Production Supervisor |
| Charlie Picerni | Stunt Coordinator |
| James Grayford | Utility Stunts |
| Karyn Fields | Researcher |
| Dino Ganziano | Hairstylist |
| Michael Papac | Property Master |
| Trudy Ramirez | Script Supervisor |
| Thomas Causey | Sound Mixer |
| E. Christopher Reed | Rigging Gaffer |
| Joseph F. Brennan | Boom Operator |
| Steve Perry | Co-Producer |
| Gregory J. Barnett | Stunts |
| Anne S. Reilly | Unit Publicist |
| Robert G. Henderson | Supervising Sound Editor |
| Richmond G. Cogswell | Video Assist Operator |
| Michael J. Burmeister | Location Manager |
| Michael Kamen | Orchestrator |
| Nick Scarano | Costume Supervisor |
| Frank B. Davis | Craft Service |
| Michael Denering | Scenic Artist |
| Alexander B. Collett | Associate Producer |
| Martin Glover | Loader |
| Jon G. Belyeu | Special Effects Coordinator |
| Eric Reasoner | Music Editor |
| Michael J. Coo | Key Grip |
| Stephen Vaughan | Still Photographer |
| Kenny Schneider | Lighting Technician |
| Bub Asman | Sound Editor |
| Jim Barr | Production Accountant |
| Stephen McLaughlin | Music Producer |
| James Simcik | Supervising ADR Editor |
| Dean Drabin | ADR Mixer |
| Christopher Blauvelt | Second Assistant Camera |
| Michael Brennan | Dolly Grip |
| Michael Kamen | Conductor |
| Leslie J. Kovacs | Chief Lighting Technician |
| Art Fransen | Technical Advisor |
| Gregory Kent Simmons | Second Assistant Director |
| Warren Gray | Second Second Assistant Director |
| Christopher Brooks | Supervising Music Editor |
| Spencer Franklin | Production Secretary |
| Scott H. Eddo | Makeup Supervisor |
| Rich E. Cordobes | Special Effects Technician |
| Sky Rockit | Assistant Camera |
| William E. Fitch | Best Boy Grip |
| Rick Chavez | Assistant Property Master |
| Steve Perry | Second Unit Director |
| Eric Gotthelf | Foley Mixer |
| Jeffrey Bornstein | Stunt Driver |
| Petra Bach | ADR Editor |
| Cynthia Neber | Executive Assistant |
| Benny McNulty | Assistant Chief Lighting Technician |
| Jesse Blanco | Production Assistant |
| Sting | Theme Song Performance |
| Dick Ziker | Stunts |
| Michael Alan Kahn | First Assistant Director |
| Cheryl Wheeler Duncan | Stunts |
| Shane Black | Characters |
| Kane Hodder | Stunts |
| Chuck Picerni Jr. | Stunts |
| Tony Brubaker | Stunts |
| Manny Perry | Stunts |
| Tim A. Davison | Stunts |
| John C. Meier | Stunts |
| Jeffrey J. Dashnaw | Stunts |
| Buddy Joe Hooker | Stunts |
| Janet Brady | Stunts |
| Tony Epper | Stunts |
| Mic Rodgers | Stunt Coordinator |
| Michael Runyard | Stunts |
| Sandy Berumen | Stunts |
| Tim Trella | Stunts |
| Tommy J. Huff | Stunts |
