 | Amanda Seyfried als Sophie |
 | Christopher Egan als Charlie |
 | Gael García Bernal als Victor |
 | Vanessa Redgrave als Claire |
 | Franco Nero als Lorenzo |
 | Luisa Ranieri als Isabella |
 | Milena Vukotić als Maria |
 | Marina Massironi als Francesca |
 | Marcia DeBonis als Lorraine |
 | Luisa De Santis als Angelina |
 | Paolo Arvedi als Signor Ricci (Olive Farmer) |
 | Lidia Biondi als Donatella |
| Dario Conti als Cheese Supplier |
| Giordano Formenti als Viticoltore |
 | Remo Remotti als Farm House Lorenzo |
 | Ivana Lotito als Young Girl |
 | Angelo Infanti als Chess Playing Lorenzo |
 | Giacomo Piperno als Lorenzo on Lake |
 | Fabio Testi als Count Lorenzo |
| Sara Armentano als Folks Home Nurse |
| Benito Deotto als Folks Home Lorenzo |
| Marcello Catania als Take Him Lorenzo |
 | Silvana Bosi als Take Him Lorenzo's Wife |
 | Elio Veller als Grocer Lorenzo |
 | Sandro Dori als Priest Lorenzo |
| Adriano Guerri als Waiter Lorenzo |
| Stefano Guerrini als Lorenzo - Grandson |
 | Daniel Emilio Baldock als Lorenzo - Father |
| Robbie Neigeborn als Sign Maker |
| Hilary Edson als Receptionist |
| Ashley Lilley als Patricia |
 | Peter Arpesella als American Tourist (voice) (uncredited) |
| Ginevra Iorio als Lorenzo - Little Granddaughter (uncredited) |
 | Laura Jane Jones als Singer - soloist (uncredited) |
| Gabriele Manfredi als Lorenzo - Grandson (uncredited) |
 | Oliver Platt als New Yorker Magazine Editor Bobby (uncredited) |
| Antonio Randazzo als Delivery Man (uncredited) |
 | Uzimann als Hot Dog Vendor (uncredited) |
| Alessandra Querzola | Set Decoration |
| Stuart Wurtzel | Production Design |
| Andrea Guerra | Original Music Composer |
| Gary Winick | Director |
| Marco Valerio Pugini | Line Producer |
| Carla Vicenzino | Makeup Artist |
| Mark Canton | Producer |
| Patrick Wachsberger | Producer |
| Marco Pontecorvo | Director of Photography |
| Eric Feig | Producer |
| Cindy Tolan | Casting |
| Jose Rivera | Screenplay |
| Bill Pankow | Editor |
| Ellen Lewis | Casting |
| Ellen Barkin | Producer |
| Nicoletta Ercole | Costume Design |
| Ron Schmidt | Executive Producer |
| Caroline Kaplan | Producer |
| Béatrice Kruger | Casting |
| Franco Maria Salamon | Stunt Coordinator |
| Saverio Sammali | Art Direction |
| Stefano Maria Ortolani | Supervising Art Director |
| Charlotte Fontijn | Script Supervisor |
| Tim Sullivan | Writer |
| John Houlihan | Music Supervisor |
| George Barkin | Co-Producer |
| Ron Schmidt | Unit Production Manager |
| Chris Carreras | First Assistant Director |
| Stefano Biraghi | Production Manager |
| Edoardo Ferretti | First Assistant Director |
| Andrea Pagani | Second Assistant Director |
| Vincenzo Carpineta | "A" Camera Operator |
| Gianni Aldi | "B" Camera Operator |
| Gianni Aldi | Steadicam Operator |
| Luciano Teolis | First Assistant "A" Camera |
| Giorgio Perluigi | Second Assistant "A" Camera |
| Alberto Torrecilla | First Assistant "B" Camera |
| Daniele Traettino | Second Assistant "B" Camera |
| David Giorgio | Video Assist Operator |
| John Johnson | Still Photographer |
| Maurizio Argentieri | Sound Mixer |
| Vincenzo Nardi | Boom Operator |
| Adriano Di Lorenzo | Boom Operator |
| Ryan Reed | Hairstylist |
| Andrew Lipschultz | Unit Publicist |
| Robert Hein | Supervising Sound Editor |
| Robert Hein | Sound Re-Recording Mixer |
| Robert Fernandez | Sound Re-Recording Mixer |
| Paul Capuano | Dolby Consultant |
