 | Josh Duhamel als Eric Messer |
 | Katherine Heigl als Holly Berenson |
 | Josh Lucas als Dr. Sam Nelson |
 | Christina Hendricks als Alison Novack |
 | Hayes MacArthur als Peter Novak |
 | Sarah Burns als Janine Groff |
 | DeRay Davis als Lonnie |
 | Rob Huebel als Ted |
 | Bill Brochtrup als Gary |
 | Andy Buckley als George Dunn |
 | Andrew Daly als Scott |
 | Majandra Delfino als Jenna |
 | Reggie Lee als Alan Burke |
 | Melissa McCarthy als DeeDee |
 | Will Sasso als Josh |
 | Jessica St. Clair als Beth |
 | Jean Smart als Helen Berenson |
 | Alexis Clagett als Sophie |
| Johanna Jowett als Jill |
 | Kate Kneeland als Female Patron |
 | Kumail Nanjiani als Simon |
| Gregory Marshall Smith als Control Room Tech (uncredited) |
| John Papsidera | Casting |
| Bruce Berman | Executive Producer |
| Denise Di Novi | Executive Producer |
| Cindy Carr | Set Decoration |
| Andrew Dunn | Director of Photography |
| Maher Ahmad | Production Design |
| Ron Bartlett | Sound Re-Recording Mixer |
| Paul Brooks | Producer |
| Scott Niemeyer | Executive Producer |
| Norm Waitt | Executive Producer |
| Austin Gorg | Art Direction |
| Zachary Woodlee | Choreographer |
| Katherine Heigl | Executive Producer |
| Barry Josephson | Producer |
| Debra McGuire | Costume Design |
| Jim Page | Editor |
| Mark Hunstable | Assistant Art Director |
| Blake Neely | Original Music Composer |
| Blake Neely | Orchestrator |
| Tania McComas | Makeup Artist |
| Richard J. Gelfand | Unit Production Manager |
| Richard J. Gelfand | Associate Producer |
| David Fletcher | Special Effects Supervisor |
| Joe Hartwick Jr. | Executive Producer |
| Greg Berlanti | Director |
| Ian Deitchman | Writer |
| Kristin Rusk Robinson | Writer |
| Dana Niu | Orchestrator |
| Vince Filippone | Additional Editing |
| Shunika Terry | Key Hair Stylist |
| Lonnie R. Smith Jr. | Stunt Coordinator |
| Richard Ziegler | Music Editor |
| Peter Iovino | Still Photographer |
| Lucia Mace | Hair Department Head |
| Joseph Cigliano | Costume Supervisor |
| Lee Wimer | Color Timer |
| Frederick H. Stahly | Dialogue Editor |
| Stacie McKinnon | Art Department Coordinator |
| Drew Ponder | Boom Operator |
| Doug Hemphill | Sound Re-Recording Mixer |
| Alicia Accardo | Script Supervisor |
| John C. Stuver | ADR Editor |
| Brad Kessell | Co-Producer |
| Karen Baker Landers | Supervising Sound Editor |
| Peter Staubli | Sound Effects Editor |
| Joseph V. Cicio | Camera Operator |
| Chris Hogan | Dialogue Editor |
| Dan Hegeman | Sound Effects Editor |
| Len Levine | Chief Lighting Technician |
| Kirk Corwin | Property Master |
| Will Arnot | Camera Operator |
| Will Arnot | Steadicam Operator |
| Jenn Moye | Art Department Assistant |
| Susan Ransom | Key Makeup Artist |
| Matt Willard | First Assistant Editor |
| Sarah Mays | Makeup Department Head |
| Jay Womer | Construction Coordinator |
| Russell Allen | Production Coordinator |
| Philip D. Morrill | Assistant Sound Editor |
| Sam Tedesco | Location Manager |
| Mary H. Ellis | Production Sound Mixer |
| Steve Humphrey | Transportation Coordinator |
| Alyson Latz | Second Assistant Director |
| Michael Lerman | First Assistant Director |
| Alexander F. Young | Co-Producer |
| Sean Flanigan | Hairstylist |
| Dylan Jury | Casting Assistant |
| Everett Chase | Set Designer |
| Dave Jackson | Assistant Editor |
| C. Alan Rawlins | Key Grip |
| Nancy Heigl | Executive Producer |
| Christy Dimmig | Post Production Supervisor |
| Elizabeth Tompkins | Production Accountant |
| Lorraine Z. Calvert | Assistant Costume Designer |
| Catherine Hahn | Costume Supervisor |
| Michael Humble | Unit Publicist |
| Megan Wiser | Key Costumer |
| Jennifer Cram | Casting Associate |
| Marty Keener Cherrix | Local Casting |
| Eliezer Katzoff | Post Production Assistant |
| Bernie Gomez | Post Production Assistant |
| Nathaniel Blume | Orchestrator |
| Marshall Bowen | Orchestrator |
