 | Viola Davis als Ma Rainey |
 | Chadwick Boseman als Levee |
 | Colman Domingo als Cutler |
 | Glynn Turman als Toledo |
 | Michael Potts als Slow Drag |
 | Jeremy Shamos als Irvin |
 | Jonny Coyne als Sturdyvant |
 | Taylour Paige als Dussie Mae |
 | Dusan Brown als Sylvester |
 | Joshua Harto als Policeman |
 | Quinn VanAntwerp als Band Singer |
 | Chloe Davis als Ma Rainey's Dancer |
| Mayte Natalio als Ma Rainey's Dancer |
| Johanna Elmina Moise als Ma Rainey's Dancer |
| Onyxx Noel als Ma Rainey's Dancer |
| LaWanda Hopkins als Ma Rainey's Dancer |
| Sierra Stewart als Ma Rainey's Dancer |
| Malaiyka Reid als Ma Rainey's Dancer |
| Catherine Foster als Ma Rainey's Dancer |
| Antonio Fierro als Laborer (uncredited) |
 | Daniel Johnson als Chicago Worker (uncredited) |
| George C. Wolfe | Director |
| Todd Black | Producer |
| Denzel Washington | Producer |
| Branford Marsalis | Original Music Composer |
| Andrew Mondshein | Editor |
| Mark Ricker | Production Design |
| Dany Wolf | Producer |
| Constanza Romero | Executive Producer |
| Ann Roth | Costume Designer |
| Tobias A. Schliessler | Director of Photography |
| Avy Kaufman | Casting |
| Michele Ziegler | First Assistant Director |
| Xanthus Valan | Second Assistant Director |
| Chuck Jeffreys | Stunt Coordinator |
| James F. Truesdale | Art Direction |
| Travis Kerr | Set Designer |
| Wes Hottman | Assistant Art Director |
| Karen O'Hara | Set Decoration |
| Paul Bucciarelli | Set Buyer |
| Diana Stoughton | Set Decoration |
| Darlene Salinas | Set Decorating Coordinator |
| Megan Graham | Script Supervisor |
| Matiki Anoff | Makeup Department Head |
| Sergio Lopez-Rivera | Makeup Artist |
| Sian Richards | Makeup Artist |
| Carl Fullerton | Makeup Artist |
| Debi Young | Makeup Supervisor |
| Skip Lievsay | Sound Re-Recording Mixer |
| Skip Lievsay | Supervising Sound Editor |
| Ruben Santiago-Hudson | Screenplay |
| Gary Archer | Prosthetics |
| Rachel Geary | Makeup Artist |
| Bethany Montecalvo | Makeup Artist |
| Bethany Townes | Makeup Artist |
| Jai Williams | Makeup Artist |
| Paul Urmson | Supervising Sound Editor |
| August Wilson | Theatre Play |
| John Allegretti | Visual Effects |
