 | Annabelle Wallis als Madison Mitchell |
 | Maddie Hasson als Sydney Lake |
 | George Young als Detective Kekoa Shaw |
 | Michole Briana White als Detective Regina Moss |
 | Susanna Thompson als Jeanne |
 | Ingrid Bisu als Winnie |
 | Jean Louisa Kelly als Jane Doe |
 | Jake Abel als Derek Mitchell |
 | Jacqueline McKenzie als Dr. Florence Weaver |
 | Christian Clemenson als Dr. Victor Fields |
 | Amir Aboulela als Dr. Gregory |
 | Mercedes Colon als Mendez |
 | Ruben Pla als Officer Rubin |
 | Jon Lee Brody als Officer Lee |
 | Paula Marshall als Beverly Woods |
 | Zoë Bell als Scorpion |
 | Shaunte Lynette Johnson als Beta |
 | Natalia Safran als Nurse Annie |
 | Mike Mendez als Hospital Security Guard #1 |
| Randy Haynie als Hospital Security Guard #2 |
| Cord Walker als Hospital Security Guard #3 |
| Jesus Trujillo als Research Doctor |
 | Lisa Catara als Research Orderly |
 | Danielle Nottingham als News Anchor |
 | Ray Chase als Gabriel (voice) |
 | Marina Mazepa als Gabriel |
 | Mckenna Grace als Young Madison |
 | Madison Wolfe als Young Serena |
 | Andy Bean als Frank |
 | Patricia Velásquez als Nurse Velasquez |
 | Patrick Cox als Mr. Stanley (uncredited) |
| Gregory Garcia als Seattle Police Officer (uncredited) |
| Emir García als Mustang Driver (uncredited) |
| Renee Harbek als Caroline (uncredited) |
 | Janet Hsieh als Nurse J. De Marco (uncredited) |
 | Paul Mabon als Orderly (uncredited) |
 | Gino Montesinos als Seattle Police Officer (uncredited) |
| Josh Rutgers als Referee (uncredited) |
| Halston Van Atta als Child Madison (uncredited) |
| Louise Van Veenendaal als Prisoner (uncredited) |
| Kalina Vanska als Seattle Police Officer (uncredited) |
 | Christina Veronica als Prisoner (uncredited) |
 | Rachel Winfree als Mrs. Ryerson (uncredited) |
| James Wan | Director |
| James Wan | Producer |
| Michael Clear | Producer |
| James Wan | Story |
| Ingrid Bisu | Story |
| Michael Burgess | Director of Photography |
| Brittany Petros | Location Manager |
| Akela Cooper | Screenplay |
| Eric McLeod | Executive Producer |
| Ingrid Bisu | Executive Producer |
| Judson Scott | Executive Producer |
| Peter Luo | Executive Producer |
| Kirk M. Morri | Editor |
| Desma Murphy | Production Design |
| Lisa Norcia | Costume Design |
| Joseph Bishara | Original Music Composer |
| Akela Cooper | Story |
| Hans Ritter | Executive Producer |
| Jennifer M. Gentile | Set Decoration |
| Stacy Bisel | Hairstylist |
| Rob Hinderstein | Makeup Artist |
| Toby Lamm | Key Makeup Artist |
| Lori McCoy-Bell | Hair Department Head |
| Koji Ohmura | Special Effects Makeup Artist |
| Kazuyuki Okada | Special Effects Makeup Artist |
| Cassie Russek | Key Hair Stylist |
| Eleanor Sabaduquia | Makeup Department Head |
| Dania Simental | Makeup Artist |
| Michael Ward | Key Hair Stylist |
| Michael White | Hair Department Head |
| Jennifer Conroy | Unit Production Manager |
| Syndey Huynh | Production Supervisor |
| Philip Waley | Unit Production Manager |
| Cristina Aragon | ADR Mixer |
| Brian Dunlop | Dialogue Editor |
| Joe Dzuban | Supervising Sound Editor |
| Joe Dzuban | Sound Designer |
| Joe Dzuban | Sound Re-Recording Mixer |
| Jacob Flack | Sound Effects Editor |
| Ben Greaves | Boom Operator |
| Julian Howarth | Sound Mixer |
| Tim LeBlanc | Sound Re-Recording Mixer |
| Chris Navarro | ADR Mixer |
| Peter Staubli | Sound Effects Editor |
| Nick DeRosa | Special Effects Technician |
| Josh Kuhn | Special Effects Assistant |
| Michael Meinardus | Special Effects Supervisor |
| Douglas D. Ziegler | Special Effects Coordinator |
| Brian Adler | Visual Effects |
| Matt Anderson | Visual Effects |
| Dan Brittain | Digital Compositor |
| Ivan Busquets | Visual Effects Supervisor |
| Katherine Chambers | Visual Effects Producer |
| Yashvhanth Chandrasekaran | Digital Compositor |
| Joel Cheyne | Visual Effects Coordinator |
| Larkin Flynn | Compositor |
| Georg Kaltenbrunner | CG Supervisor |
| Ravi Krishna Kasumarthy | Digital Compositor |
| Samira Khan | Visual Effects Coordinator |
| Charles Lai | Compositing Supervisor |
| Alberto Landeros | Digital Compositor |
| Mathias Lautour | CG Supervisor |
| Cedric Lo | Animation Supervisor |
| Adrian Millington | Animation Supervisor |
| Diego Piccinato | Digital Compositor |
| Brian Shows | Visual Effects Producer |
| Katrina Taylor | Visual Effects Editor |
| Yegor Tesler | Visual Effects Coordinator |
| Luke Vallee | Digital Compositor |
| David E. Scott | Supervising Art Director |
| Anne McCarthy | Casting |
| Kellie Roy | Casting |
| Tiffany Abney | Stunt Double |
| Heather Bonomo | Stunt Double |
| Solomon Brende | Stunt Double |
| Bryan Cartago | Stunt Double |
| Darrell Davis | Stunts |
| Danny Downey | Stunts |
| Ed Duran | Stunts |
| Brittania Fader | Stunt Double |
| Glenn Foster | Stunt Coordinator |
| Craig Henningsen | Stunts |
| Cyrus Leisy | Stunts |
| Krystle Martin | Stunts |
| Molly Miller | Stunts |
| Miluette Nalin | Stunt Double |
| Blakely Olson | Stunt Driver |
| Lauren Shaw | Stunt Double |
| Mallory Thompson | Stunt Double |
| Emerald Gordon Wulf | Stunts |
| Raul Contreras | Set Dresser |
| Tim Croshaw | Set Designer |
| Cody Recker | Set Dresser |
| Anne Porter | Set Designer |
| Avi Wolfe | On Set Dresser |
| David Marnell | Second Second Assistant Director |
| Jeffrey Wetzel | First Assistant Director |
| Travis Cantey | First Assistant Editor |
| Jorge Diaz | Assistant Editor |
| Paul Sage | Digital Intermediate Editor |
| Pamela Scott-Farr | Digital Intermediate Producer |
| Kerry Lyn McKissick | Script Supervisor |
| Loyd Bateman | Fight Choreographer |
| Loyd Bateman | Stunt Coordinator |
| Brett A. Jones | Stunts |
| Morgan Benoit | Stunt Double |
| Craig Branham | Stunt Double |
| Monica Lopez Aleman | Stunt Double |
| Katie O'Donovan | Stunt Double |
| Gee Alexander | Stunt Double |
| Natascha Hopkins | Stunt Double |
| Tara Macken | Stunt Double |
| Angela Meryl | Stunt Double |
| Brett Praed | Stunt Double |
| Daniel Stevens | Stunt Double |
| Mark Aaron Wagner | Stunt Double |
| Vaia Zaganas | Stunt Double |
| Sala Baker | Stunt Double |
| Joey Box | Stunt Double |
| Michelle Jubilee Gonzalez | Stunt Double |
| Sierra Hoyle | Stunt Double |
| Elisa Sargent | Stunt Double |
| Lee-Anne Telford | Stunt Double |
| Sonja Wajih | Stunt Double |
| Troy James | Acting Double |
| Odin Benitez | Sound Designer |
| Eliot Connors | Sound Designer |
| Justin Dzuban | Sound Effects Editor |
| AP Amal Kumar | Sound Re-Recording Mixer |
| David Werntz | Sound Effects Editor |
| Nico Alvarado | Set Costumer |
| Victoria Cameron | Set Costumer |
| Courtney Franzese | Set Costumer |
| Kersten Haff | Set Costumer |
| Jenna Mason | Set Costumer |
| Brooke Mulkins | Set Costumer |
| David Profeta | Assistant Costume Designer |
| Demetrios Katsantonis | Set Dresser |
| Jeanie King | Executive Visual Effects Producer |
| Daniel Benjamin | Studio Teacher |
