 | Dylan O'Brien als Thomas |
 | Ki Hong Lee als Minho |
 | Kaya Scodelario als Teresa Agnes |
 | Thomas Brodie-Sangster als Newt |
 | Dexter Darden als Frypan |
 | Alexander Flores als Winston |
 | Jacob Lofland als Aris Jones |
 | Rosa Salazar als Brenda |
 | Giancarlo Esposito als Jorge |
 | Patricia Clarkson als Ava Paige |
 | Aidan Gillen als Janson |
 | Lili Taylor als Mary Cooper |
 | Barry Pepper als Vince |
 | Nathalie Emmanuel als Harriet |
 | Alan Tudyk als Blondie |
 | Terry Dale Parks als Carl (Masked Man) |
 | Kathryn Smith-McGlynn als Dr. Crawford |
 | Matt Metzler als Barkley |
 | Jenny Gabrielle als Ponytail |
 | David House als Soldier |
 | Lora Martinez-Cunningham als Thomas' Mother |
| Luke Gallegos als Young Thomas |
 | Shawn Prince als David |
 | Jeremy Becerra als Riley |
 | Matthew Page als Harold (Soldier) |
 | Alex Knight als Aide |
| Marc Comstock als Med Tech |
| John Trejo als M3 Soldier |
 | Katherine McNamara als Sonya |
 | Tatanka Means als Joe |
 | Ryan Jason Cook als Nurse |
 | James Burnett als Rebel Sentry |
 | Morse Bicknell als Doctor |
 | Adriana Acosta als Glader (uncredited) |
| Brian Barela als Bunker Soldier (uncredited) |
| Laramie Cooley als Abigail (uncredited) |
 | Jetto Dorsainville als WCKD / Bunker Militia (uncredited) |
 | Andrea Good als Ash People (uncredited) |
 | Carma Harvey als Scavenger (uncredited) |
| Gary Hood als Glader (uncredited) |
 | Keith Jardine als Scavenger Guard (Jim) (uncredited) |
 | Jess King als WCKD Soldier (uncredited) |
 | Martin Palmer als Rave Party Guest (uncredited) |
| Frank Powers als Soldier (uncredited) |
 | Ben Pronsky als Additional Voices (voice) (uncredited) |
| James Tyler Robinson als Glader (uncredited) |
 | Gonzalo Robles als Hazmat Soldier (uncredited) |
 | Bryce Romero als Jack (uncredited) |
| Diego Romero als Scavenger Guard (uncredited) |
 | J. Nathan Simmons als Ash Mob Evacuee (uncredited) |
 | Kaelee Vigil als Civilian (uncredited) |
| Alexander Wagenman als Kid on Train (uncredited) |
| Richard Daniel Williams als Right Arm Militia (uncredited) |
 | John Christian Love als Surveillance Room Attendant |
| Daniel Casillas | Makeup Effects |
| Wes Ball | Director |
| Wes Ball | Executive Producer |
| Daniel T. Dorrance | Production Design |
| Lindsay Williams | Executive Producer |
| Marty Bowen | Producer |
| T.S. Nowlin | Screenplay |
| James Dashner | Novel |
| T.S. Nowlin | Executive Producer |
| Ellen Goldsmith-Vein | Producer |
| Lee Stollman | Producer |
| Gyula Pados | Director of Photography |
| Wyck Godfrey | Producer |
| Edward Gamarra | Executive Producer |
| Sanja Milković Hays | Costume Design |
| Dan Zimmerman | Editor |
| Joe Hartwick Jr. | Producer |
| Denise Chamian | Casting |
| Billy W. Ray | Art Direction |
| Kari King | Set Costumer |
| Katie L. Murphy | Set Costumer |
| Geordie Sheffer | Hair Department Head |
| Janessa Bouldin | Hairstylist |
| Daniel Bombell | First Assistant Camera |
| Reyna Robinson | Hairstylist |
| Dan O'Connell | Foley |
| Shayna Brown | Sound Re-Recording Mixer |
| Lora McKenny | Set Costumer |
| Drew Nielsen | Visual Effects Coordinator |
| Steve Dubin | Visual Effects Producer |
| Sara Roybal | Makeup Artist |
| Tom Woodruff Jr. | Makeup Designer |
| Richard K. Buoen | Conceptual Design |
| Ron Bartlett | Sound Re-Recording Mixer |
| P.J. Burch | First Assistant Editor |
| Chloe Feodoroff | Visual Effects Coordinator |
| Megan Daum | Key Hair Stylist |
| Lee Gilmore | Sound Effects Editor |
| David Zimmerman | First Assistant Editor |
| Jason Chen | Visual Effects Producer |
| Bill Holmquist | Construction Coordinator |
| James R. Tynes | Gaffer |
| Ai-Ling Lee | Supervising Sound Editor |
| Vicki M. McWilliams | Art Department Coordinator |
| Gina G. Aller | Costume Supervisor |
| Steve Gehrke | Script Supervisor |
| Victor Huang | Animation |
| Martin Wiseman | Visual Effects Producer |
| Jon Shroyer | Makeup Artist |
| Kelly Berry | Set Decoration |
| Jade Mansueto | Animation Director |
| Margaux Peach | Visual Effects Coordinator |
| Frieda Valenzuela | Makeup Artist |
| Nava R. Sadan | Costume Supervisor |
| Rolf Fleischmann | Visual Effects Editor |
| Leonard MacDonald | Makeup Effects |
| Kingslea Bueltel | First Assistant Camera |
| Rosanna Dill | Set Costumer |
| Shaun Friedberg | Animation Director |
| R. Christopher White | Visual Effects Supervisor |
| Jeff Carson | Music Editor |
| Isaac Hamon | Stunt Coordinator |
| Scott Puckett | Visual Effects Producer |
| Teri Ann Uccan | Hairstylist |
| Richard Foreman Jr. | Still Photographer |
| George Cottle | Stunt Coordinator |
| Liz Ludwitzke | Casting Associate |
| Irena Stepić | Assistant Costume Designer |
| Jana Jungk | Visual Effects Coordinator |
| Charles Martin Inouye | Music Editor |
| Ashley Edwards | Set Costumer |
| Aaron Gilman | Animation Supervisor |
| Ken Barthelmey | Creature Design |
| Ai-Ling Lee | Sound Designer |
| Craig Young | Animation |
| Keith O'Hara | Visual Effects Coordinator |
| Jeremy Hollis | Visual Effects Coordinator |
| Betty D. Lawson | Hairstylist |
| Karen McDonald | Makeup Department Head |
| Jerrad Gray | Makeup Effects |
| Michael Kelem | Helicopter Camera |
| Beth Day | Casting Associate |
| Delana Veirs | Hairstylist |
| Dave Snyder | Makeup Effects |
| David J. Thompson | Steadicam Operator |
| John T. Cucci | Foley |
| Bob Kellough | Sound Effects Editor |
| Brian Malone | Rigging Grip |
| Andrew Max Cahn | Supervising Art Director |
| Leon Woud | Animation Director |
| Thomas E. Surprenant | Makeup Effects |
| Isaac Hai Swee Tan | Animation |
| Sharla Cipicchio | First Assistant Camera |
| David Greene | Special Effects Coordinator |
| Mark Aaron Wagner | Stunts |
| Brett Andrews | Property Master |
| Tim Gomillion | Sound Recordist |
| John Paesano | Original Music Composer |
| Richard E. Hollander | Visual Effects Supervisor |
| Justin Muller | First Assistant Director |
| John M. Morse | Second Assistant Director |
| Kevin Abercrombie | Stunts |
| Cody Banta | Stunts |
| Damien Bray | Stunts |
| Dan Brown | Stunts |
| Matthew Lee Christmas | Stunts |
| Ilram Choi | Stunts |
| Shane Daniels | Stunts |
| Tom Crisp | Stunts |
| Chris Donaldson | Stunts |
| Steve DeCastro | Stunts |
| Ed Duran | Stunts |
| Timothy Eulich | Stunts |
| Tait Fletcher | Stunts |
| Glenn Foster | Stunts |
| Anthony Genova | Stunts |
| Mark Ginther | Stunts |
| Tommy Goodwin | Stunts |
| Greg Harris | Stunts |
| Adam Hart | Stunts |
| Jess King | Stunts |
| Alex Kingi | Stunts |
| Horace Knight Jr. | Stunts |
| Kara Petersen | Stunts |
| Mark Rayner | Stunts |
| Alice Rietveld | Stunts |
| Ivor Shier | Stunts |
| Ryan Staats | Stunts |
| Brent Steffensen | Stunts |
| Bryan Thompson | Stunts |
| Frank Torres | Stunts |
| Jay Torrez | Stunts |
| Torrey Vogel | Stunts |
| Saleem Watley | Stunts |
| Christie Hayes | Stunts |
| Bjarne Sletteland | Art Direction |
| Patrick Scalise | Assistant Art Director |
| Brooke Peters | Set Designer |
| Siobhan Roome | Set Designer |
| Derrick Ballard | Set Designer |
| Julian Scalia | Art Department Assistant |
| Stephen P. Durante | Leadman |
| Severino Gonzales | On Set Dresser |
| Linda R. Gore | Set Dresser |
| Graham Griswold | Set Dresser |
| Lonam Fogleman | Set Dresser |
| Ethan Scroggins | Set Dresser |
| Paul Mugavero | Set Dresser |
| Dale Lotreck | Set Dresser |
| Walter E. Myal | Second Second Assistant Director |
| Paul Ledford | Production Sound Mixer |
| Kevin Maloney | Boom Operator |
| David McKimmie | Post Production Supervisor |
| John A. Larsen | Supervising Sound Editor |
| Kurt Kornemann | Key Grip |
| Maria Bentfield | Key Costumer |
| Wynema Chavez | Ager/Dyer |
| Jesse Trevino | Ager/Dyer |
| Jonathon Slator | Location Manager |
| Forrest A. Haag | Assistant Property Master |
| Liz Probst | Payroll Accountant |
| Elizabeth Gabel | Extras Casting |
| Patrick A. Reynolds Jr. | Transportation Coordinator |
| Wolf Schneider | Unit Publicist |
| Vanessa Lapato | ADR Supervisor |
| John Murray | Foley Supervisor |
| Matthew Harrison | Foley Editor |
| Scott Curtis | Foley Editor |
| Galen Goodpaster | First Assistant Sound Editor |
| David Wolowic | Assistant Sound Editor |
| David Betancourt | ADR Mixer |
| Christine Sirois | ADR Recordist |
| James Ashwill | Foley Mixer |
| John Guentner | Foley Mixer |
| Richard Duarte | Foley Mixer |
| David Clayton | Title Designer |
| Loan Phan | Digital Intermediate Producer |
| Lisa Tutunjian | Digital Intermediate Editor |
| Hiroshi Mori | Visual Effects |
