 | Guillaume Canet als Astérix |
 | Gilles Lellouche als Obélix |
 | Vincent Cassel als Jules César |
 | Jonathan Cohen als Graindemaïs |
 | Julie Chen als Princesse Fu Yi |
 | Leanna Chea als Tat Han |
 | Marion Cotillard als Cléopâtre / Bibine |
 | José Garcia als Biopix |
 | Manu Payet als Ri Qi Qi |
 | Ramzy Bedia als Epidemaïs |
 | Bun-hay Mean als Deng Tsin Qin |
 | Linh-Dan Pham als L'Impératrice |
 | Pierre Richard als Panoramix |
 | Gérard Darmon als Le narrateur (voice) |
 | Tran Vu Tran als Prince du Deng |
 | Philippe Katerine als Assurancetourix |
 | Jérôme Commandeur als Abraracourcix |
 | Audrey Lamy als Bonnemine |
 | Franck Gastambide als Le capitaine Barbe-Rouge |
 | Vincent Desagnat als Perfidus |
 | Orelsan als Titanix |
 | Laura Felpin als Carioca |
 | Issa Doumbia als Baba, la vigie des pirates |
 | Thomas VDB als Sinus |
 | Monsieur Fraize als Plexus |
 | Florian Ordonez als Abdelmalix |
 | Olivio Ordonez als Toufix |
 | David Coscas als Radius |
 | Raphaël Carlier als Cubitus |
 | Tatiana Gousseff als Iélosubmarine |
 | Yann Papin als Abribus |
 | Angèle als Falbala |
 | Matthieu Chedid als Remix |
 | Jason Chicandier als Ordralfabétix |
 | Zlatan Ibrahimović als Antivirus |
 | Samuel Hibon als Lapsus |
 | Marc Hoang als Ramoli |
 | Philippe Canet als Agecanonix |
 | Florent Manaudou als Tabascos |
 | Ted Etienne |
 | Ragnar Le Breton |
 | Wesley Weigel als Pirate |
| Sakhone Holaphong als Chinese villager |
| André Kalmes als Cétautomatix |
| Guillaume Canet | Director |
| Philippe Mechelen | Writer |
| Julien Hervé | Writer |
| Guillaume Canet | Writer |
| René Goscinny | Characters |
| Albert Uderzo | Characters |
| Alain Attal | Producer |
| André Chemetoff | Director of Photography |
| Matthieu Chedid | Original Music Composer |
| Madeline Fontaine | Costume Designer |
| Laurent Nogueira | Casting |
| Mathilde Snodgrass | Casting |
| Aline Bonetto | Production Design |
| Mathieu Junot | Production Design |
| Bertrand Clercq-Roques | Art Direction |
| Sandrine Jarron | Supervising Art Director |
| Dominique Moisan | Art Direction |
| Ludivine Roux | Assistant Costume Designer |
| Florence Batteault | Makeup Artist |
| Avril Carpentier | Makeup Artist |
| Delphine Duguet | Makeup Artist |
| Magalie Dumas | Makeup Artist |
| Manon Dumas | Makeup Trainee |
| Stéphanie Guillon | Key Makeup Artist |
| Mathilde Humeau | Key Makeup Artist |
| Lucky Nguyen | Makeup Artist |
| Patricia Prevot | Makeup Artist |
| Sandrine Roman | Assistant Makeup Artist |
| Lisa Schonker | Key Makeup Artist |
| Agnieszka Szumacher | Key Makeup Artist |
| Hue Lan Van Duc | Makeup Designer |
| Achille Auzanneau | Assistant Unit Manager |
| Mickaël Bagdian | Assistant Unit Manager |
| Maxime Bedue | Assistant Unit Manager |
| Lionel Bouilhac | Assistant Unit Manager |
| Aurélie Bruyère | Assistant Unit Manager |
| Anthony Cazet | Unit Manager |
| Sophie Clavaizolle | Assistant Unit Manager |
| Jan de Calbiac | Assistant Unit Manager |
| Stanislas De Lardemelle | Unit Manager |
| Philippe Girard | Assistant Unit Manager |
| Baptiste Gourvennec | Assistant Unit Manager |
| Elise Jullien | Assistant Unit Manager |
| Anne-Hélène Kerner | Assistant Unit Manager |
| Laurent Lafond | Assistant Unit Manager |
| johan lanoé | Assistant Unit Manager |
| Johanna Le Saux | Assistant Unit Manager |
| Maxime Lebard | Assistant Unit Manager |
| Pierre Maury | Assistant Unit Manager |
| Réjane Ruby | Assistant Unit Manager |
| Nicolas Mouchet | Post-Production Manager |
| Sandrine Paquot | Production Manager |
| Audrey Thiery | Set Designer |
| Jim Thomasson | Assistant Unit Manager |
| Maxime Valleix | Assistant Unit Manager |
| Eloïse Dang Van | Assistant Unit Manager |
| Clara Zegrodzki | Production Assistant |
| Victoria Correia | Additional Third Assistant Director |
| Hélène Fabre | Second Assistant Director |
| Romain Hervieux | Second Assistant Director |
| Virginie Jousset | Assistant Director |
| Julie Pliouchtch | Additional Second Assistant Director |
| Théo Richard | Assistant Director |
| Théodore Vuillequez | Additional Third Assistant Director |
| Winifrey Bandera-Guzman | Casting Assistant |
| Estelle Brision | Casting Assistant |
| Julie Gandossi | Casting Assistant |
| Virginie Jousset | Extras Casting |
| Luna Loy | Casting Assistant |
| Vianney Perez | Casting Assistant |
| Nina Morille | Extras Casting |
| Mylène Ragon | Extras Casting Assistant |
| Ines Sanchez | Colorist |
| Iacono Gabriel | Craft Service |
| Laurent Perrot | Location Manager |
| Fabien Pondevaux | Location Scout |
| Axel Sorensen | Assistant Location Manager |
| Angèle Pignon | Assistant Script |
| Chloé Rudolf | Script Supervisor |
| Clément Lepoix | Transportation Captain |
| Dorothée Santucci | Production Accountant |
| Marion Gerard | Production Coordinator |
| Léa Adriansen | Assistant Set Dresser |
| Stephanie Angrand | First Assistant Art Direction |
| Chouchane Bakirel | Assistant Art Director |
| Cali Berthet | Painter |
| Paul Bourcart | Weapons Master |
| Mathias Canard | Set Dresser |
| Mathieu Champel | Painter |
| Julie Robert de Beauchamp | Property Master |
| Jonathan Delerue | Storyboard Artist |
| Carine Demongueres | Set Designer |
| Garance Fligny | Painter |
| Leslie Martinelli | Painter |
| Omid Gharakhanian | Construction Buyer |
| Virginie Irdel | Assistant Art Director |
| Charline Jaillard | Assistant Set Dresser |
| Alison Naudin | Painter |
| Muriel Nicolle | Sculptor |
| Emmanuelle Olle | Property Buyer |
| Victoria Poirier | Assistant Art Director |
| Adrien Poujade | Assistant Set Dresser |
| Thierry Poulet | Assistant Art Director |
| Warina Contreras Ramos | Sculptor |
| Sylvain Rigollot | Storyboard Artist |
| Patricia Ruelle | Graphic Designer |
| Bernon Sebastien | Carpenter |
| Benjamin Stierle | Painter |
| Angélique Verbeeck | Second Assistant Art Director |
| Simon Witte | Assistant Art Director |
| Jonathan Acbard | Boom Operator |
| Rémi Daru | Production Sound Mixer |
| Clément Delarbre | Sound |
| Yannis do Couto | Sound |
| Fred Messa | Boom Operator |
| Nicia Mougenot | Sound |
| Chiara Nardo | Sound |
| Josselin Panchout | Boom Operator |
| Nicolas Paturle | Boom Operator |
| Clément Wintz | Special Effects |
| Stéphanie Pottier | Visual Effects Coordinator |
| Hugues Namur | Visual Effects Supervisor |
| Aurelie Lajoux | Visual Effects Supervisor |
| Nicolas Lacroix | Visual Effects Producer |
| Bryan Jones | Visual Effects Supervisor |
| Michel Denis | Visual Effects Producer |
| Ciaran Aguenier | Electrician |
| Thomas Bazin | Second Assistant Camera |
| Simon Berthaud | Additional Grip |
| Eric Bialas | Camera Operator |
| Eric Bialas | Steadicam Operator |
| David Bigard | Additional Grip |
| Stéphane Blum | Electrician |
| Franck Bonomi | Rigging Grip |
| Jimmy Bourcier | Additional First Assistant Camera |
| Didier Bourel | Best Boy Electric |
| Damien Bret | Electrician |
| Adrien Grasswill | Electrician |
| Georges Harnack | Electrician |
| Simon Bérard | Gaffer |
| Etienne Dang | Second Assistant Camera |
| Pierre Helie De Peretti | Additional Grip |
| Tangui Delahodde | Additional Grip |
| Carl Demaille | Grip |
| Nicolás Díaz | Digital Imaging Technician |
| Jorge Escribens | Drone Operator |
| Hugues Espinasse | Director of Photography |
| Mathilde Fernandez | Camera Trainee |
| David Foquin | First Assistant Camera |
| Yannick Freess | Best Boy Grip |
| Malek Krimed | First Assistant Camera |
| Charles Lagorce | Grip |
| Benjamin Lavayssière | Drone Pilot |
| Benjamin Lemonnyer | Electrician |
| Jeremy Mauroy | First Assistant Camera |
| Laurent Mengolli | Additional Grip |
| Guillaume Mondin | Grip |
| Mathieu Mouterde | Electrician |
| Victor Nigil | Grip |
| Vincent Paté | Video Assist Operator |
| Marie-Lou Penando | Electrician |
| Florent Perrin | Data Management Technician |
| Lise Porte | Electrician |
| Laurent Pouchard | Grip |
| Rémi Quilichini | Steadicam Operator |
| Marc Rossero | Electrician |
| Laurent Schepman | Best Boy Grip |
| Victor Servel | Electrician |
| Pablo Sotes | Drone Pilot |
| Kevin Strauch | Additional Grip |
| Gregoire Thevenot | First Assistant Camera |
| Cyril Vannier | Additional Grip |
| Marc Wilhelm | Key Grip |
| Haruyo Yokota | Second Assistant Camera |
| Marie Credou | Costumer |
| Emilie Hug | Wardrobe Assistant |
| Mathilde Lévêque | Wardrobe Assistant |
| Julian Moeglin | Wardrobe Assistant |
| Dustin Audibert | Utility Stunts |
| Hugo Bariller | Fight Choreographer |
| Eddy Benguedih | Stunt Double |
| Frans Boyer | Stunts |
| Romain Canonne | Stunts |
| Oscar Casellas | Stunts |
| Alexandre Cauderlier | Stunt Coordinator |
| Kévin Cauderlier | Stunt Coordinator |
| Patrick Cauderlier | Stunt Coordinator |
| Amedéo Cazzella | Stunts |
| Maurice Chan | Stunts |
| Quentin D'Hainaut | Stunts |
| Jean Eudes Drouvin | Stunts |
| Ludovic Faure | Stunts |
| Olivier Fornara | Stunts |
| Thibault Gassmann | Stunts |
| David Grolleau | Stunts |
| Clément Huet | Stunts |
| Robin Lallart | Stunts |
| Thitsady Voravong | Stunts |
| Mael Lamberton | Stunts |
| Charles Lecoq | Stunts |
| Alexandre Levand | Stunts |
| Vincent Marotta | Stunts |
| Alexandre Moreira | Stunts |
| Michel Nguyen | Stunts |
| Anthony Pho | Stunts |
| Mario Preaud | Stunts |
| Vibol-Joseph Sok | Stunts |
| Sebastien Soudais | Stunts |
| Alexandre Vu | Stunts |
| Guillaume Castagné | Special Effects Makeup Artist |
| Marison De | Special Effects Makeup Artist |
| Sarah Pariset | Special Effects Makeup Artist |
| Olivier Afonso | Special Effects Makeup Artist |
| Laetitia Hillion | Special Effects Makeup Artist |
| Cyril Hipaux | Special Effects Makeup Artist |
| Aimée Blot | Special Effects Makeup Artist |
| Clément Wintz | Special Effects Makeup Artist |
| Brice Tholozan | Drone Cinematographer |
| Elliott Carrasco | Drone Cinematographer |
