 | Steve Carell als Gru (voice) |
 | Pierre Coffin als Kevin / Stuart / Bob / Minions (voice) |
 | Alan Arkin als Wild Knuckles (voice) |
 | Taraji P. Henson als Belle Bottom (voice) |
 | Michelle Yeoh als Master Chow (voice) |
 | Julie Andrews als Gru's Mom (voice) |
 | Russell Brand als Dr. Nefario (voice) |
 | Jean-Claude Van Damme als Jean Clawed (voice) |
 | Dolph Lundgren als Svengeance (voice) |
 | Danny Trejo als Stronghold (voice) |
 | Lucy Lawless als Nun-Chuck (voice) |
 | Jimmy O. Yang als Henchman 1 (voice) |
 | Kevin Michael Richardson als Henchman 2 (voice) |
 | John DiMaggio als Henchman 3 (voice) |
 | RZA als Biker (voice) |
 | Michael Beattie als VNC Announcer / Guru Rick (voice) |
 | Will Arnett als Mr. Perkins (voice) |
 | Steve Coogan als Silas Ramsbottom (voice) |
 | Colette Whitaker als Gru's Teacher (voice) |
 | Raymond S. Persi als Birthday Kid (voice) |
 | Kyle Balda als Additional Voices (voice) |
 | Bob Bergen als Additional Voices (voice) |
 | Beau Billingslea als Additional Voices (voice) |
 | Cathy Cavadini als Additional Voices (voice) |
 | David Chen als Additional Voices (voice) |
 | Will Collyer als Additional Voices (voice) |
 | Meilee Condron als Additional Voices (voice) |
 | Antonio Raul Corbo als Additional Voices (voice) |
 | Debi Derryberry als Additional Voices (voice) |
 | Scarlett Estevez als Additional Voices (voice) |
 | Kellen Goff als Additional Voices (voice) |
 | Jake Green als Additional Voices (voice) |
 | Isa Hall als Additional Voices (voice) |
 | Ramone Hamilton als Additional Voices (voice) |
 | Aaron Hendry als Additional Voices (voice) |
 | Barbara Harris als Additional Voices (voice) |
 | JP Karliak als Additional Voices (voice) |
 | Evan Kishiyama als Additional Voices (voice) |
 | Sam Lavagnino als Additional Voices (voice) |
 | Dawnn Lewis als Additional Voices (voice) |
| Amari McCoy als Additional Voices (voice) |
| Levi Nunez als Additional Voices (voice) |
 | Benjamin Plessala als Additional Voices (voice) |
 | Alex Puccinelli als Additional Voices (voice) |
| David J. Randolph als Additional Voices (voice) |
| Carla Rempp als Additional Voices (voice) |
 | Nev Scharrel als Additional Voices (voice) |
 | James Sie als Additional Voices (voice) |
 | Mindy Sterling als Additional Voices (voice) |
 | Fred Tatasciore als Additional Voices (voice) |
 | Regina Taufen als Additional Voices (voice) |
 | Nisa Ward als Additional Voices (voice) |
 | Debra Wilson als Additional Voices (voice) |
 | Nora Wyman als Additional Voices (voice) |
| Janet Healy | Producer |
| Chris Meledandri | Producer |
| Chris Renaud | Producer |
| Jack Antonoff | Music Producer |
| Kelly Lake | Associate Producer |
| Claire Dodgson | Editor |
| Claire Lentz | Color Designer |
| Habib Louati | Storyboard Artist |
| Mark O'Hare | Additional Storyboarding |
| Cinco Paul | Characters |
| Patrick Muylkens | Color Designer |
| Mark Oftedal | Visual Development |
| Robert Taylor | Associate Producer |
| Jean-Luc Florinda | Co-Producer |
| Matthew Fogel | Screenplay |
| Jérémie Droulers | Sculptor |
| James Moreau | Graphic Designer |
| Nima Azarba | Storyboard Artist |
| Mark Koetsier | Storyboard Artist |
| Brett Nystul | Visual Development |
| Edwin Rhemrev | Set Designer |
| Latifa Ouaou | Executive Producer |
| Gregory Georges | Color Designer |
| Darren Webb | Storyboard Artist |
| Heitor Pereira | Original Music Composer |
| Kyle Balda | Director |
| Jonathan del Val | Co-Director |
| Brad Ableson | Co-Director |
| Brian Lynch | Story |
| Carter Goodrich | Character Designer |
| Kevin Parker | Songs |
| Diana Ross | Songs |
| Matthieu Gosselin | Art Direction |
| Heikki Kossi | Foley Artist |
| Thierry Fournier | Art Direction |
| Jason Butler | Foley Recordist |
| Justin Doyle | Sound Effects Editor |
| Christopher Flick | Foley Supervisor |
| Richard Gould | Foley Editor |
| Jeff King | Sound Re-Recording Assistant |
| Tim Nielsen | Sound Re-Recording Mixer |
| Tim Nielsen | Sound Designer |
| Tim Nielsen | Supervising Sound Editor |
| Brandon Proctor | Sound Re-Recording Mixer |
| Michael Rivera | ADR Mixer |
| Steve Slanec | Supervising Sound Editor |
| James Spencer | Dialogue Editor |
| Kari Vähäkuopus | Foley Recordist |
| Matthew Wood | ADR Mixer |
| Andre Zweers | Sound Effects Editor |
| Matthew Fogel | Story |
