 | Tom Cruise als Ethan Hunt |
 | Philip Seymour Hoffman als Owen Davian |
 | Ving Rhames als Luther Stickell |
 | Billy Crudup als John Musgrave |
 | Michelle Monaghan als Julia Meade |
 | Jonathan Rhys Meyers als Declan Gormley |
 | Keri Russell als Lindsey Farris |
 | Maggie Q als Zhen Lei |
 | Simon Pegg als Benjamin 'Benji' Dunn |
 | Eddie Marsan als Brownway |
 | Laurence Fishburne als Theodore Brassel |
 | Bahar Soomekh als Davian's Translator |
 | Jeff Chase als Davian's Bodyguard |
 | Michael Berry Jr. als Julia's Kidnapper |
 | Carla Gallo als Beth |
 | Bellamy Young als Rachael |
 | Paul Keeley als Ken |
 | Jane Daly als Julia's Mother |
 | Greg Grunberg als Kevin |
 | Sabra Williams als Annie |
 | Rose Rollins als Ellie |
 | Sasha Alexander als Melissa Meade |
 | Tracy Middendorf als Ashley |
 | Aaron Paul als Rick Meade |
 | Kathryn Fiore als Party Goer |
 | Colleen Crozier als Party Goer |
 | Sean O'Bryan als Party Goer |
 | Bruce French als Minister |
 | Ellen Bry als Lindsey's Mother |
 | Patrick Pankhurst als Lindsey's Father |
 | Tony Guma als Jim |
 | James Shanklin als Hospital Chaplain |
 | Anne Betancourt als Nurse Sally |
 | Antonietta De Lorenzo als Roadblock Driver |
 | Andrea Sartoretti als Roadblock Driver |
 | Antonio Del Prete als Vatican Video Room Guard |
 | Francesco De Vito als Greeting Priest |
 | Giorgio Marchesi als Vatican Gate Guard |
 | Niccolò Senni als Vatican Gate Guard |
 | Paolo Bonacelli als Monsignore |
| David Waters als IMF Officer |
 | Michael G. Kehoe als Hospital Employee |
 | Timothy Omundson als IMF Agent |
 | José Zúñiga als IMF Agent Pete |
 | William Francis McGuire als IMF Head of Security |
 | Michelle Arthur als Airline Worker |
 | Barney Cheng als Janitor |
 | George Cheung als Shanghai Game Player (uncredited) |
 | Brandon Molale als Torturer (uncredited) |
 | Simon Rhee als Chinese Guard at Hengshan Lu Building (uncredited) |
 | Marcus Young als Chinese Guard (uncredited) |
 | Jerry Trimble als Davian's Thug (uncredited) |
 | Alex Kurtzman als Party Guest (uncredited) |
 | Roberto Orci als Party Guest (uncredited) |
| Tom Cruise | Producer |
| Colleen Atwood | Costume Design |
| April Webster | Casting |
| Donna O'Neal | Key Set Costumer |
| Brad Ricker | Art Direction |
| Barney Burman | Special Effects Makeup Artist |
| Maggie Fung | Key Makeup Artist |
| Sean Haworth | Art Direction |
| Enzo Sisti | Line Producer |
| Vito Colazzo | Unit Production Manager |
| Renato Agostini | Special Effects Supervisor |
| Paula Wagner | Producer |
| Lalo Schifrin | Main Title Theme Composer |
| Stephen Bream | Art Direction |
| Michèle Burke | Makeup Artist |
| Michèle Burke | Makeup Supervisor |
| Dennis Bradford | Art Direction |
| Bruce Geller | Original Series Creator |
| Kevin Kavanaugh | Art Direction |
| Mark P. Stoeckinger | Supervising Sound Editor |
| J.J. Abrams | Director |
| J.J. Abrams | Writer |
| Alex Kurtzman | Writer |
| Roberto Orci | Writer |
| Michael Giacchino | Original Music Composer |
| Michael Giacchino | Orchestrator |
| Dan Mindel | Director of Photography |
| Maryann Brandon | Editor |
| Mary Jo Markey | Editor |
| Scott Chambliss | Production Design |
| Karen Manthey | Set Decoration |
| Warren Hanneman | Hairstylist |
| Stephen M. Davis | Music Editor |
| Daniel Acon | Special Effects Coordinator |
| Daniel Sudick | Special Effects |
| Nina Fallon | Visual Effects Coordinator |
| Vic Armstrong | Stunt Coordinator |
| Vic Armstrong | Second Unit Director |
| Wade Allen | Stunts |
| Daniel T. Dorrance | Supervising Art Director |
| Scott Rathner | First Assistant "B" Camera |
| Matthew J. Birch | Production Supervisor |
| Han Sanping | Executive Producer |
| Yang Buting | Executive Producer |
| Gary Kosko | Art Direction |
| Chris Palermo | Stunt Driver |
| Chad S. Frey | Set Designer |
| Domenic Silvestri | Art Direction |
| Bill Borden | Supervising Producer |
| Zhao Hai-Cheng | Producer |
| Caitlin McKenna | ADR Voice Casting |
| Andy Cheng | Stunts |
| Jennifer Caputo | Stunt Double |
| Michiko Nishiwaki | Stunts |
| Stefan Sonnenfeld | Colorist |
| Casey O'Neill | Stunt Double |
| David Witz | Unit Production Manager |
| Spice Williams-Crosby | Stunt Driver |
| Jamie Marshall | First Assistant Director |
| Cliff Fleming | Aerial Coordinator |
| Michael Kehoe | Craft Service |
| Jiang Tao | Co-Producer |
| Angelique Midthunder | Stunt Driver |
| Eric Schwab | Second Unit Director |
| Billy D. Lucas | Stunts |
| Don Coufal | Boom Operator |
| Garrett Warren | Stunts |
| Michael Kamper | Sound Effects Editor |
| Curt Beech | Assistant Art Director |
| Mandy Sherman | Casting Associate |
| Sabine Engelberg | Art Department Assistant |
| Diane Collins | Additional Script Supervisor |
| Edoardo Petti | Second Assistant Director |
| Mark Meyers | "C" Camera Operator |
| Armen Ksajikian | Musician |
| Stratton Leopold | Executive Producer |
| Katherine Lee | Executive In Charge Of Production |
| Robin Harlan | Foley Artist |
| Arthur Anderson | Co-Producer |
| Scott Trimble | Assistant Location Manager |
| Randy Singer | Foley Mixer |
| Cheryl Beasley Blackwell | Costume Supervisor |
| Alan Rankin | Sound Designer |
| Paul Timothy Carden | ADR Editor |
| Roger Guyett | Visual Effects Supervisor |
| Beth Sterner | Sound Editor |
| Trisha Burton | Script Supervisor |
| Bruce McCleery | Chief Lighting Technician |
| Steven Melton | Property Master |
| Maxwell R. Johnson II | Transportation Captain |
| Sebastian Milito | Construction Coordinator |
| Jasin Boland | Still Photographer |
| Philippe Carr-Forster | Camera Operator |
| Christopher Prampin | Assistant Chief Lighting Technician |
| Jeremy Braben | Aerial Director of Photography |
| Colin Anderson | Steadicam Operator |
| Colin Anderson | "A" Camera Operator |
| Anna Behlmer | Sound Re-Recording Mixer |
| Mark Fellman | Additional Still Photographer |
| Phillip Dawe | Post Production Coordinator |
| Alex Jaeger | Visual Effects Art Director |
| Dawn Gilliam | Script Supervisor |
| Candice D. Campos | Production Coordinator |
| Laura Harris Atkinson | Dialogue Editor |
| Kerry Dean Williams | ADR Supervisor |
| Leonardo Beltrame | Electrician |
| Des Carey | Digital Intermediate Producer |
| Andrea Alunni | Unit Manager |
| Richard Hughes | Second Second Assistant Director |
| Deborah Rutherford | Key Makeup Artist |
| Christine L. Cantella | Assistant Costume Designer |
| Jessica Drake | Dialect Coach |
| Derek Casari | ADR Engineer |
| Daniel Mattig | Unit Manager |
| Daniel Mattig | Second Assistant Director |
| Mike Smith | Stunts |
| Rebecca Qin Jiang | Sound Assistant |
| Todd Wolcott | Greensman |
| Monica Frommholz | Set Decoration Buyer |
| Robert Alonzo | Stunts |
| Danny Bramson | Music Supervisor |
| Tyler Allison | Camera Department Manager |
| Russell Allen | Assistant Production Coordinator |
| Robert Consing | Storyboard Artist |
| Bruce Powell | Sequence Supervisor |
| Norman Ludwin | Musician |
| Eliza Coleman | Stunts |
| Kerry Joseph Blackman | Post Production Assistant |
| Alessia Anfuso | Assistant Set Decoration |
| Michael Scheel | Unit Production Manager |
| Marco Graziaplena | Camera Loader |
| Paul Kavanagh | Animation Supervisor |
| John T. Connor | First Assistant "A" Camera |
| Gregory J. Pawlik Jr. | Trainee Production Coordinator |
| Jeff Wexler | Production Sound Mixer |
| Debbi Bossi | Post Production Supervisor |
| Alex Levy | Music Editor |
| Diane Collins | Script Supervisor |
| Matthew Harrison | Foley Editor |
| Margie Kaklamanos | Makeup Department Head |
| Viviane Normand | Key Hair Stylist |
| Terry Atchison | Armorer |
| Pablo Borges | Costume Illustrator |
| Chris Samp | Set Painter |
| Wayne Baker | Aerial Camera Technician |
| Al Goto | Stunts |
| Marco Alzari | Wardrobe Assistant |
| Don Steinberg | First Assistant Camera |
| Martin Allan Kloner | Visual Effects Editor |
| Carmen Flores De Tanis | Assistant Sound Editor |
| Martin Bosworth | Rigging Gaffer |
| Florian Dieckmann | Production Driver |
| Heidi Moneymaker | Stunt Double |
| Steve Wolfe | Second Assistant "B" Camera |
| Brad Arnold | Second Assistant Director |
| Dana Dru Evenson | Stunts |
| Julie Helton | Second Assistant "C" Camera |
| Daniele Abeille | Transportation Coordinator |
| James Carson | Production Illustrator |
| Inti Carboni | First Assistant Director |
| Geoffrey Mandel | Graphic Designer |
| Steve Lionetti | Production Supervisor |
| Harry Lu | Weapons Master |
| Dane Farwell | Stunts |
| Velvet Andrews-Smith | Second Second Assistant Director |
| Massimo Gubinelli | Color Timer |
| Adriana De La Cruz | Set Medic |
| Steve Harding | Production Manager |
| Andrew P. Flores | Standby Painter |
| Bryant Powell | Stand In |
| Rich Andrade | Set Dresser |
| Dan Ming | First Assistant "C" Camera |
| Jim Davidson | Production Controller |
| Tommy Gormley | First Assistant Director |
| Cory Fleming | Pilot |
| Thomas Gibson | Key Grip |
| Paolo Frasson | Rigging Grip |
| Debbie Schwab | Production Supervisor |
| Karin Silvestri | Stunts |
| Luigi Spoletini | First Assistant Director |
| R. Ben Adams | Set Production Assistant |
| Nicola Marzano | Second Second Assistant Director |
| Danny Wynands | Stunts |
| Willy Faso | Unit Production Manager |
| Mark Bourgeois | Assistant Editor |
| Andrew Ward | Second Second Assistant Director |
| Pete Asidilla | Dolly Grip |
| Shane Andersen | Grip |
| Sara Gardner-Gail | Set Decoration Buyer |
| Brandon Lambdin | Second Assistant Director |
| Craig Gadsby | Leadman |
| Guy Botham | Executive Visual Effects Producer |
| Scott Bauer | Assistant Property Master |
| Mark Carlile | Lighting Technician |
| Annie Ellis | Stunts |
| Edoardo Ferretti | Second Second Assistant Director |
| Maria Fiorito | Production Accountant |
| Riccardo Umetelli | Focus Puller |
| Eric Kops | Publicist |
| Tony Wright | Construction Buyer |
| Mark Ormandy | Sound Recordist |
| Tommy Harper | First Assistant Director |
| Dennis Yeager II | Special Effects |
| Bonita Deneen | Casting Assistant |
| Chrysta Marie Burton | Visual Effects Production Assistant |
| Stephanie Portnoy Porter | Costumer |
| Naomi Villanueva-Brunner | Second Assistant "A" Camera |
| David Waters | Second Assistant Director |
| Mathew Dunne | First Assistant Director |
| Imelda Betiong | First Assistant Editor |
| James Michael Miller | Production Secretary |
| Jamie Daddio | First Assistant Accountant |
| Don Crawford | Digital Compositor |
| Thomas R. Homsher | Prop Designer |
| Dawn Blacksten | Location Manager |
| Jennifer Bender | Extras Casting |
| Elana Joy Livneh Lessem | Visual Effects Assistant Editor |
| Chris Bangma | Libra Head Technician |
| James Payfer | Rotoscoping Artist |
| Rick Rader | Key Rigging Grip |
| Stephanie Antosca | Location Scout |
| Eric Taylor Williamson | ADR Recordist |
| Luke Allein | Assistant Camera |
| Thomas Coe | Second Second Assistant Director |
| Cristiana Agostinelli | Set Costumer |
| Crystal Gong Chun | Second Assistant Director |
| Veronica Gambacurta | Painter |
| Doming Shi | Co-Producer |
| Guichun Wang | Associate Producer |
| Jia Ji Cheng | Second Second Assistant Director |
| Fannie Dai Hong | Second Second Assistant Director |
| Lemon Liu Yi-Man | Second Assistant Director |
| Sylvia Liu | First Assistant Director |
| Daniele Ramazzotti | Third Assistant Director |
| Valerio Stati | Third Assistant Director |
| Eddie Thorne | Second Second Assistant Director |
| Silvia Vascellari | Second Second Assistant Director |
| Wen Jie Yang | Second Second Assistant Director |
| Andreas Kassab | Second Assistant Director |
| Mario Pegoretti | Hairstylist |
| Tony Bridgers | Carpenter |
| Matthew Sordello | Sound |
| Roderic 'Mick' Duff | Special Effects Coordinator |
| Sandra Jelmini | Art Department Coordinator |
| Emiliano Barretta | Driver |
| Ryan D. Compton | Propmaker |
| Robert M. Bouffard | Props |
| David Giammarco | Creative Consultant |
| Fausto Cancellieri | Machinist |
| Peter Onsmark | Set Production Intern |
| Luo San Claire | Translator |
| Amanda Brand | Unit Publicist |
| Tom Loewy | Video Assist Operator |
| Greg Turnbull | Costume Assistant |
| Amy Glenn | Costumer |
| Benedict C. Adams | Special Effects Technician |
| Diego Guerra | Stunt Driver |
| Anna Ferrarie | Camera Production Assistant |
| Don Domino | First Company Grip |
| Andrea Piria | Accountant |
| Lauren Niggl | Additional Production Assistant |
| David Bojarski | Assistant Accountant |
| Jesse Hynes | Generator Operator |
| Mandy Sprinkel | Local Casting |
| Jeremy Cook | Matte Painter |
| Hiromi Marder | Payroll Accountant |
| Laurent Lavigne | Pre-Visualization Supervisor |
| Whitney Arnold | Production Assistant |
| Nick Jordan | Travel Coordinator |
| Stefano Olivieri | Set Dresser |
