 | Kate Mara als Lee Weathers |
 | Anya Taylor-Joy als Morgan |
 | Toby Jones als Dr. Simon Ziegler |
 | Rose Leslie als Dr. Amy Menser |
 | Boyd Holbrook als Skip Vronsky |
 | Michelle Yeoh als Dr. Lui Cheng |
 | Jennifer Jason Leigh als Dr. Kathy Grieff |
 | Paul Giamatti als Dr. Alan Shapiro |
 | Michael Yare als Ted Brenner |
 | Chris Sullivan als Dr. Darren Finch |
 | Vinette Robinson als Dr. Brenda Finch |
 | Brian Cox als Jim Bryce |
 | Crispian Belfrage als Charles Grimes |
 | Amybeth McNulty als Morgan (age 10) |
 | Jonathan Aris als David Chance |
 | Charlotte Asprey als Executive Assistant |
| Tom McCullagh | Production Design |
| Luke Scott | Director |
| Seth W. Owen | Writer |
| Max Richter | Music |
| Laura Jennings | Editor |
| Gary Campbell | Armorer |
| Ryan McNeill | Armorer |
| Andrea Bamford | Script Supervisor |
| Marie Clare Cushinan | Script Supervisor |
| Mark Patten | Director of Photography |
| Michael Connell | Music Editor |
| Tony Lewis | Music Editor |
| Mark Huffam | Producer |
| Michael Schaefer | Producer |
| Ridley Scott | Producer |
| Carmen Cuba | Casting |
| Charley Medigovich | Casting Associate |
| John Merry | Art Direction |
| Daniel Swingler | Assistant Art Director |
| Elaine McLenachan | Set Decoration |
| Fiona Gavin | Supervising Art Director |
| Stefano De Nardis | Costume Design |
| Sarah Robinson | Costume Supervisor |
| Geri Doherty | Set Costumer |
| Maurizio Torti | Set Costumer |
| Imanol Nabea | Camera Operator |
| Aidan Monaghan | Still Photographer |
| Vinny Madden Jr. | Gaffer |
| Andy Gardner | First Assistant Camera |
| Eric Greenberg | First Assistant Camera |
| Simon Cockren | Special Effects Supervisor |
| Lucy Ainsworth-Taylor | Visual Effects Producer |
| Angela Barson | Visual Effects Supervisor |
| Rupert Davies | Visual Effects Supervisor |
| Becki Ponting | ADR & Dubbing |
| Hugo Adams | Foley |
| Mike Dowson | Sound Re-Recording Mixer |
| Aidan Bradley | Hairstylist |
| Jordan Samuel | Makeup Designer |
| Rob Farris | Digital Intermediate |
| Patrick Malone | Digital Intermediate |
| Peter N. Brown | Construction Manager |
| Alex Boyd | Production Manager |
| Aidan Elliott | Executive Producer |
| George F. Heller | Executive Producer |
| Elishia Holmes | Executive Producer |
| Paul Herbert | Stunt Coordinator |
| James Smith | Unit Production Manager |
| William Dodds | First Assistant Director |
| Tom Mulberge | Second Assistant Director |
| Derek Hehir | Production Sound Mixer |
| Markus Stemler | Sound Designer |
| Mark Taylor | Supervising Sound Editor |
| Matt Collinge | Supervising Sound Editor |
| Deborah McCarthy | Makeup Supervisor |
| Lisa McConville | Makeup Artist |
| Lorna Carmichael | Visual Effects Coordinator |
| Matt Collinge | Sound Re-Recording Mixer |
| Davide Losi | Prosthetics |
