 | Johnny Depp als Charlie Mortdecai |
 | Gwyneth Paltrow als Johanna Mortdecai |
 | Ewan McGregor als Inspector Alistair Martland |
 | Paul Bettany als Jock Strapp |
 | Jonny Pasvolsky als Emil Strago |
 | Olivia Munn als Georgina Krampf |
 | Jeff Goldblum als Milton Krampf |
 | Michael Culkin als Sir Graham Archer |
 | Ulrich Thomsen als Romanov |
 | Alec Utgoff als Dmitri |
 | Guy Burnet als Maurice |
 | Paul Whitehouse als Spinoza |
 | Norma Atallah als Bronwen |
 | Nicholas Farrell als Auctioneer |
 | Karl Theobald als Gardener |
 | Michael Byrne als The Duke |
 | James Joyce als Duke's Footman |
| Emily Lawrence als Woman in Jock's Apartment |
| Carly Steel als Krampf's Third Wife |
 | Jenna Russell als Detective |
 | Austin Lyon als Hotel Clerk |
 | Ricky Champ als Sergei |
 | Chris Bearne als Farmer |
| Georgie Carter als Farmer's Daughter |
 | Benny Maslov als Romanov's Aide |
 | Colette O'Neil als The Duchess |
| Evie Brodie als Mum on Plane |
| Michael Aguiló als Revolutionary |
 | Michael Shelford als Sedgewicks Worker |
 | Junix Inocian als Fang Fat |
 | Jamie Bernadette als Bikini Babe (uncredited) |
 | Joey Courteau als Hotel Guest (uncredited) |
| Kyril Bonfiglioli | Writer |
| David Koepp | Director |
| Eric Aronson | Writer |
| Kenneth Kokin | Co-Producer |
| Michael Kneafsey | Boom Operator |
| Ruth Myers | Costume Design |
| Andrew Lazar | Producer |
| Sam Sarkar | Executive Producer |
| Elaine Grainger | Casting |
| Seb Palmer | Carpenter |
| Tom Symes | Carpenter |
| Paul Rigby | Carpenter |
| Sarah Grispo | Makeup Artist |
| Sallie Jaye | Hair Designer |
| Nigel Dawes | Painter |
| Gareth Cousins | Art Direction |
| Sara Wan | Set Decoration |
| Helena Barrett | Makeup Artist |
| Michael Paseornek | Executive Producer |
| Katia Lewin Jablonsky | Music Editor |
| Joel Harlow | Makeup Artist |
| Jutta Russell | Makeup Artist |
| Alex Abelman | Carpenter |
| Tom Fleischman | Sound Re-Recording Mixer |
| Johnny Depp | Producer |
| Jules Holdren | Hairstylist |
| Josh Blair | Score Engineer |
| Kat Law | Art Direction |
| Florian Hoffmeister | Director of Photography |
| John Papsidera | Casting |
| Julie M. Anderson | Production Supervisor |
| Tony Dawe | Production Sound Mixer |
| Sallie Jaye | Makeup Designer |
| Steve Patterson | Carpenter |
| Ron Bochar | Sound Re-Recording Mixer |
| Joe Carey | Boom Operator |
| Patrick McCormick | Producer |
| Jill Savitt | Editor |
| Marianne Jenkins | Unit Production Manager |
| Paul A. Levin | Post Production Supervisor |
| Rebecca White | Assistant Art Director |
| David Raymond | Boom Operator |
| Christi Dembrowski | Producer |
| Derek Ambrosi | Editor |
| James Merifield | Production Design |
| David Lazan | Art Direction |
| Peta Dunstall | Hairstylist |
| Patrick McCormick | Line Producer |
| Monique Feig | Co-Producer |
| Patrick Rolfe | Supervising Art Director |
| Gigi Pritzker | Producer |
| Gloria Pasqua Casny | Hair Department Head |
| Allan Zaleski | Sound Effects Editor |
| Mark Wallis | Carpenter |
| Mark Ronson | Original Music Composer |
| David Appleby | Still Photographer |
| Sue Hills | Script Supervisor |
| Chris Cull | Property Master |
| Geoff Zanelli | Original Music Composer |
| Alexa Zimmerman | Dialogue Editor |
| Deborah Wallach | Supervising ADR Editor |
| Marcus Samperi | Camera Operator |
| Whitney Coleman | Stunt Double |
| Tad Griffith | Stunt Coordinator |
| Jill Brown | Stunt Driver |
| Sian Milne | Stunts |
| G. A. Aguilar | Stunt Coordinator |
| G. A. Aguilar | Second Unit Director |
| Conrad E. Palmisano | Stunts |
| Danny Wynands | Stunts |
| Casey O'Neill | Stunt Driver |
| James Armstrong | Stunt Double |
| Christopher Leps | Stunt Double |
| Tara Macken | Stunt Double |
| Matthew Sharp | Assistant Director |
