 | Jim Carrey als Tom Popper |
 | Carla Gugino als Amanda |
 | Angela Lansbury als Mrs. Van Gundy |
 | Ophelia Lovibond als Pippi |
 | Madeline Carroll als Janie Popper |
 | Clark Gregg als Nat Jones |
 | Jeffrey Tambor als Mr. Gremmins |
 | David Krumholtz als Kent |
 | Philip Baker Hall als Franklin |
 | Maxwell Perry Cotton als Billy |
 | James Tupper als Rick |
 | Dominic Chianese als Reader |
 | William Charles Mitchell als Yates |
 | Henry Kelemen als Young Tommy Popper |
 | Kelli Barrett als Tommy's Mom |
 | Dylan Clark Marshall als Young Tommy Popper #2 |
 | Brian T. Delaney als Young Tom Popper, Sr. (voice) |
 | Elaine Kussack als Gremmins's Secretary |
 | Harlin C. Kearsley als Town Car Driver |
 | Desmin Borges als Daryl |
 | Lee Moore als Reginald |
 | Dominic Colón als Tito |
 | Jeff Lima als Freddy |
| Frank Ciornei als Klaus |
 | J.R. Horne als Arnold |
 | Matthew Wolf als Antarctic Friend (voice) |
 | Andrew Stewart-Jones als Animal Control Guy |
 | James Chen als Fish & Game Officer |
 | Rafael Osorio als Marine & Waterfowl Officer |
| Curtis Shumaker als Sanitation Officer |
 | Joseph D'Onofrio als Random Man on Street |
 | Olga Merediz als Nanny |
 | Betsy Aidem als Tavern Hostess |
 | Angel Caban als Fishmonger |
| Chris Beetem als Young Developer |
 | Charles L. Campbell als Old Tom Popper, Sr. (voice) |
 | Daniel Stewart Sherman als Zoo Security Guard |
 | Mike Massimino als Cop #1 |
 | Charlie Semine als Cop #2 (Quint) |
 | Cynthia Kirchner als Pulse Lounge Beautiful Girl (uncredited) |
| Mark Waters | Director |
| Sean Anders | Screenplay |
| John Morris | Screenplay |
| Tony Mecca | Animation |
| Samidha Nagwekar | Animation |
| Alexander Fernandes | Animation |
| Rohit Kolhe | Animation |
| Dixie Pizani | Animation |
| Daniel Lindsey | Visual Effects |
| Bill Corso | Makeup Artist |
| Bruce Green | Editor |
| Derek Dauchy | Executive Producer |
| Ellen Christiansen | Set Decoration |
| Kathleen Chopin | Casting |
| Jessica Tuchinsky | Executive Producer |
| Mark Waters | Executive Producer |
| Patricia Woodbridge | Art Direction |
| Marci Liroff | Casting |
| Ann Roth | Costume Design |
| Jonathan Filley | Co-Producer |
| Joel Gotler | Executive Producer |
| Ira Napoliello | Co-Producer |
| Linda Fields | Associate Producer |
| John Davis | Producer |
| Stuart Wurtzel | Production Design |
| Rolfe Kent | Music |
| Florian Ballhaus | Director of Photography |
| John A. Machione | Unit Production Manager |
| Jonathan Filley | Unit Production Manager |
| Stephen Apicella | First Assistant Director |
| Matt Power | Second Assistant Director |
| Richard E. Hollander | Visual Effects Supervisor |
| Blondel Aidoo | Visual Effects Producer |
| Mark A. Mangini | Sound Designer |
| Mark A. Mangini | Sound Supervisor |
| Andy Koyama | Sound Re-Recording Mixer |
| Ron Bartlett | Sound Re-Recording Mixer |
| Doug Hemphill | Sound Re-Recording Mixer |
| Danny Michael | Sound Mixer |
| Joel Holland | Video Assist Operator |
| John G. Velez | Gaffer |
| Charlie Marroquin | Key Grip |
| Susan Bakula | Tailor |
| Barry Wetcher | Still Photographer |
| Julie Kuehndorf | Unit Publicist |
| Gary Cergol | Graphic Designer |
| Nora Kasarda | Art Department Coordinator |
| Patrick McDonald | Second Second Assistant Director |
| Renee Burke | Script Supervisor |
| Liza D. Espinas | First Assistant Editor |
| Ron Petagna | Construction Coordinator |
| Johnny Gidcomb | ADR Voice Casting |
| Alicia Stevenson | Foley Artist |
| Dawn Fintor | Foley Artist |
| Val Kuklowsky | ADR Editor |
| Donald Flick | Foley Editor |
| Julie Feiner | Dialogue Editor |
| Laura Harris Atkinson | Dialogue Editor |
| Daniel S. Irwin | Dialogue Editor |
| Charleen Richards-Steeves | ADR Mixer |
| Piero Mura | Sound Effects Editor |
| Mike Chock | Sound Effects Editor |
| Christopher T. Welch | ADR Supervisor |
| David Lucarelli | ADR Recordist |
| Scott Curtis | Foley Mixer |
| Timothy Shannon | Transportation Captain |
| Lukasz Jogalla | Second Unit Director of Photography |
| G. A. Aguilar | Stunt Coordinator |
| Stephen A. Pope | Stunt Coordinator |
| Blaise Corrigan | Stunt Coordinator |
| G. A. Aguilar | Second Unit Director |
| Nick South | Music Editor |
| Steve Apicella | First Assistant Director |
| Aja Frary | Stunt Double |
| Peter Epstein | Stunts |
