 | Nathan Lane als Ernest "Ernie" Smuntz |
 | Lee Evans als Lars Smuntz |
 | Vicki Lewis als April Smuntz |
 | Maury Chaykin als Alexander Falko |
 | Eric Christmas als Ernie and Lars' Lawyer |
 | Michael Jeter als Quincy Thorpe |
 | Debra Christofferson als Ingrid |
 | Camilla Søeberg als Hilde, the Bench Lady |
 | Ian Abercrombie als Auctioneer |
 | Annabelle Gurwitch als Roxanne Atkins |
 | Eric Poppick als The Banker |
 | Ernie Sabella als Maury, the Cat Care Society Owner |
 | William Hickey als Rudolph Smuntz |
 | Christopher Walken als Caeser, the Exterminator |
 | Cliff Emmich als Mayor McKrinle |
 | Melanie MacQueen als Mayor's Wife |
| Brianna Shebby als Becky |
| Danielle Shebb als Betty |
| Leslie Upson als Leslie Reinhart |
 | Mario Cantone als Zeppco Suit #1 |
| Peter Anthony Rocca als Zeppco Suit #2 |
| Steve Bean als Lester Dinkus |
 | Suzanne Krull als Waitress #1 |
 | William Frankfather als Mr. Texas |
 | Frank Welker als Catzilla, Mouse |
 | Jack Angeles als Kennel Employee |
 | Greg Bronson als Neighbor |
 | Whit Hertford als Vinny |
 | Susan Blommaert als Ms. Park Avenue |
 | Valorie Armstrong als Franklin's Wife |
| Alan Silvestri | Music |
| Bruce Cohen | Producer |
| Gore Verbinski | Director |
| Craig Wood | Editor |
| Denise Chamian | Casting |
| Phedon Papamichael | Director of Photography |
| Wally Pfister | Camera Operator |
| Wally Pfister | Second Unit Director of Photography |
| Linda DeScenna | Production Design |
| M. James Arnett | Stunt Coordinator |
| John R. Jensen | Assistant Art Director |
| Catherine Harper | Foley Artist |
| Bradley M. Goodman | Post Production Supervisor |
| Dino DiMuro | Sound Effects Editor |
| Bart Brown | Associate Producer |
| Sharon Smith Holley | Visual Effects Editor |
| James Nedza | Art Direction |
| Ric McElvin | Set Decoration |
| Keith Campbell | Stunts |
| Bryan Bowen | Sound Effects Editor |
| Mic Rodgers | Stunts |
| Sally Thornton | Assistant Art Director |
| Jill M. Ohanneson | Costume Design |
| Christopher Lawrence | Costume Supervisor |
| Tony Ludwig | Producer |
| Alan Riche | Producer |
| Adam Rifkin | Screenplay |
| Mark Vargo | Second Unit Director of Photography |
| Mary Locatell | Production Illustrator |
| Arlene Kehela | Location Manager |
| Herb Gains | Unit Production Manager |
| Alisa Christensen | Stunts |
| Rafael E. Sánchez | Gaffer |
| Bob Herron | Stunts |
| Charlie Picerni | Stunts |
| Michael Lantieri | Special Effects Coordinator |
| Michael Kehoe | Craft Service |
| Carla Meyer | Dialect Coach |
| James Ward Byrkit | Production Illustrator |
| James Moriana | Foley Artist |
| Lorey Sebastian | Still Photographer |
| Al Hobbs | Set Designer |
| John K. Adams | Foley Editor |
| Martin Lopez | Sound Effects Editor |
| Julie Hewett | Key Makeup Artist |
| Meg Goodwin | Key Costumer |
| Alan Rankin | Sound Effects Editor |
| Dan O'Connell | Foley Artist |
| Robin L. Neal | Makeup Artist |
| Dan DiPrima | Music Editor |
| Jon Title | Sound Effects Editor |
| Denny Caira | Transportation Coordinator |
| John T. Cucci | Foley Mixer |
| Stan Tropp | Set Designer |
| Lauren Cory | Set Designer |
| Mike Shannon | Transportation Captain |
| Sharron Reynolds-Enriquez | Script Supervisor |
| Jenny Fulle | Visual Effects Producer |
| Linda Lew | Foley Recordist |
| Casey Hotchkiss | Camera Operator |
| Candace Neal | Key Hair Stylist |
| Richard Dwan Jr. | Dialogue Editor |
| Gregory Hainer | Sound Effects Editor |
| Dan Hegeman | Dialogue Editor |
| Chris Jargo | ADR Editor |
| Alex L. Worman | Unit Publicist |
| Tommy Tomlinson | Property Master |
| Chris Jackson | Assistant Editor |
| Bruce J. Gfeller | Construction Coordinator |
| Barbara J. Boguski | ADR Editor |
| Tony Bacigalupi | Assistant Editor |
| Charles Gibson | Visual Effects Supervisor |
| Patrick Hoeschen | Electrician |
| Robert Batha | First Assistant Sound Editor |
| Eliza Coleman | Stunts |
| Benita Allen | First Assistant Director |
| Philip D. Morrill | Assistant Sound Editor |
| Bob Hall | First Assistant Camera |
| Gary Dahlquist | Rigging Gaffer |
| Kris Peck | Assistant Property Master |
| Dan M. Rich | Dialogue Editor |
| Al Goto | Stunts |
| Arthur Farkas | Foley Editor |
| Tony Negrete | Assistant Sound Editor |
| Jim Turner | Production Controller |
| Mary Ruth Smith | ADR Editor |
| Nancy Gilmore | Leadman |
| Timothy P. Salmon | Boom Operator |
| Nico Bally | Grip |
| Simon Morgan | Assistant Editor |
| Bob Putynkowski | Color Timer |
| Jarek Gorczycki | Best Boy Electric |
| Jeff Hall | Electrician |
| Michael J. Coo | Key Grip |
| Lou Kleinman | Foley Editor |
| Mary Finn | Set Designer |
| Lee Schmicker | Electrician |
| Elena Holden Tuens | Production Accountant |
| Ralph Peterson | Construction Foreman |
| David W. Alstadter | Foley Mixer |
| Steven J. Mikolas | Video Assist Operator |
| Jacqueline Tager | Music Editor |
| Alan Steinman | Second Second Assistant Director |
| Michael Brennan | Dolly Grip |
| Frederic Roth | Second Assistant Director |
| Holly Davis | Costumer |
| Bob Orrison | Stunts |
| Julie Lucas | Foley Recordist |
| Vicki Niemi | Unit Production Manager |
| John P. Cleveland | Grip |
| Lisa Swain | Production Coordinator |
| Michael T. Travers | Grip |
| Deborah Slate | Assistant Costume Designer |
| Alan Z. McCurdy | First Assistant Editor |
| Annie Ellis | Stunts |
| Romy Fleming | Hairstylist |
| Lee Auerbach | Electrician |
| Lee W. Lebaigue | Assistant Sound Editor |
| Ashley Cook | Art Department Coordinator |
| Maria DeVane | Post Production Accountant |
| Michael A. Mendez | Grip |
| Craig Kohtala | Best Boy Grip |
| Lisa Marie Serra | Post Production Coordinator |
| Peter McManus | Assistant Accountant |
| John Ceniceros | Set Dresser |
| David "DJ" Harder | Second Assistant Camera |
| Ken Cottengim Jr. | Grip |
| Steve Luce | Transportation Captain |
| Ann Szakmeister | Dialogue Editor |
| Claudette Cucci | Foley Artist |
