 | Emma Roberts als Nancy Drew |
 | Max Thieriot als Ned Nickerson |
 | Josh Flitter als Corky Veinshtein |
 | Rachael Leigh Cook als Jane Brighton |
 | Kay Panabaker als Georgie |
 | Tate Donovan als Carson Drew |
 | Marshall Bell als John Leshing |
 | Daniella Monet als Inga Veinshtein |
 | Kelly Vitz als Trish |
 | Bruce Willis als Bruce (uncredited) |
 | Laura Harring als Dehlia Draycott |
 | Barry Bostwick als Dashiel Biedermeyer |
 | Craig Gellis als Thug |
 | Rich Cooper als Charlie |
 | Amy Bruckner als Bess |
 | Cliff Bemis als Chief McGinnis |
 | David Doty als Father Murray |
 | Pat Carroll als Landlady |
 | Monica Parker als Hannah |
 | Caroline Aaron als Barbara Barbara |
 | Phil Abrams als Principal Fineman |
 | Joanne Baron als Costume Lady |
 | Ryan Raddatz als Assistant Director |
 | Adam Goldberg als Arrogant Director Andy |
 | Emmy Laybourne als File Lady |
 | Elyssa Davalos als Twin Palms Manager |
| Kaitlyn Van Item als Allie Brighton |
 | Robert Merrill als 'New Century' Actor |
 | Chris Kattan als Burglar |
 | Lindsay Sloane als Boutique Clerk |
| Jerry Weintraub | Producer |
| Jeffrey Kurland | Costume Design |
| Ben Waisbren | Executive Producer |
| Tony Fanning | Production Design |
| Cherylanne Martin | Unit Production Manager |
| Cherylanne Martin | Co-Producer |
| Jeff Freeman | Editor |
| Ron Bartlett | Sound Re-Recording Mixer |
| Pam Dixon | Casting |
| Mark Vahradian | Executive Producer |
| Alexander Gruszynski | Director of Photography |
| Julie M. Anderson | Production Supervisor |
| Andrew Fleming | Screenplay |
| Andrew Fleming | Director |
| Susan Ekins | Executive Producer |
| Kathy Lucas | Set Decoration |
| Tiffany Paulsen | Screenplay |
| Tiffany Paulsen | Story |
| Ralph Sall | Original Music Composer |
| Ralph Sall | Music Supervisor |
| Soo-Jin Yoon | Hairstylist |
| John Robotham | Stunt Coordinator |
| Eric Flickinger | Sound Recordist |
| Todd Cherniawsky | Art Direction |
| James Plannette | Gaffer |
| Mildred Wirt Benson | Characters |
| Julie Hewett | Makeup Department Head |
| Melinda Sue Gordon | Still Photographer |
| Doug Hemphill | Sound Re-Recording Mixer |
| Erik Liles | Visual Effects Supervisor |
| Gregory King | Supervising Sound Editor |
| Yann Delpuech | Sound Designer |
| Shaughnessy Hare | Sound Effects Editor |
| Henry Tirl | Steadicam Operator |
| Dale Myrand | Camera Operator |
| Susan Malerstein | Script Supervisor |
| Charles Martin Inouye | Music Editor |
| Medusah | Hair Department Head |
| Marie Larkin | Key Hair Stylist |
| Robb Earnest | Production Coordinator |
| R. Michael De Chellis | Rigging Gaffer |
| Julie Kristy | Makeup Artist |
| Jeena M. Phelps | Dialogue Editor |
| Kendall Errair | Costume Supervisor |
| Petra Demas | Assistant Editor |
| Jeffrey S. Lorenz | First Assistant Camera |
| Al Goto | Stunts |
| Brian Avery | Stunts |
| Timothy S. Wiles | Property Master |
| Karine Mauffrey | Stunt Double |
| Eric Tignini | First Assistant Director |
| Alex Betuel | Set Production Assistant |
| Edward Stratemeyer | Novel |
