 | Frank Welker als George / Duck / Cow (voice) |
 | Amy Hill als Flower Pot Lady / Irate Woman (voice) |
 | Ed O'Ross als Ivan the Doorman (voice) |
 | Carlos Alazraqui als Newspaper Vendor / Conductor (voice) |
 | Jeff Bennett als Ted (voice) |
 | Fred Tatasciore als Mr. Bloomsberry (voice) |
 | Nickie Bryar als Maggie / Teenage Boy (voice) |
 | Jamie Kennedy als "Danno" Wolfe (voice) |
 | Catherine Taber als Tina (voice) |
 | Tim Curry als Piccadilly (voice) |
| Jeff McNeal als Kayla / Hog / Tonga / Layla (voice) |
 | Cree Summer als Ms. Fisher / Cargo Pilot (voice) |
 | Matt Lauer als Hark Hanson (voice) |
 | Melissa Greenspan als Phone Operator (voice) |
 | Jerry Lewis als Stationmaster (voice) |
 | Clint Howard als Farmer Dan (voice) |
| Trupti Potdukhe als Anna (voice) |
 | Phil LaMarr als Animal Park Attendant (voice) |
 | Cam Clarke als Additional Voices (voice) |
 | Lara Cody als Additional Voices (voice) |
| Greg Dawson als Additional Voices (voice) |
 | John Kassir als Additional Voices (voice) |
 | Cynthia Songé als Additional Voices (voice) |
 | Steve Staley als Additional Voices (voice) |
| Norton Virgien | Director |
| Matt Williames | Art Department Manager |
| Susan Blu | Casting |
| John Bryant | Editor |
| Heitor Pereira | Original Music Composer |
| Jim Whitaker | Co-Executive Producer |
| David Bernardi | Co-Executive Producer |
| Ron Howard | Executive Producer |
| Brian Grazer | Executive Producer |
| David Kirschner | Executive Producer |
| Jon Shapiro | Executive Producer |
| Share Stallings | Producer |
| Chuck Tately | Story |
| Chuck Tately | Screenplay |
| Darrell Rooney | Story |
| Leanne Moreau | Associate Producer |
| Bob Kline | Art Direction |
| Andrei Svislotski | Head of Story |
| David Vasquez | Production Coordinator |
| Slamm Andrews | Music Editor |
| Frederick Howard | Sound Supervisor |
| Elliott Koretz | Sound Effects Editor |
| Derek Pippert | Foley Supervisor |
| Jeff Rosen | Dialogue Editor |
