 | Cary Grant als Roger O. Thornhill |
 | Eva Marie Saint als Eve Kendall |
 | James Mason als Phillip Vandamm |
 | Jessie Royce Landis als Clara Thornhill |
 | Leo G. Carroll als Le Professeur |
 | Josephine Hutchinson als Vandamm's Sister aka Mrs. Townsend |
 | Philip Ober als Lester Townsend |
 | Martin Landau als Leonard |
 | Adam Williams als Valerian |
 | Edward Platt als Victor Larrabee |
 | Robert Ellenstein als Licht |
 | Les Tremayne als Auctioneer |
 | Philip Coolidge als Dr. Cross |
 | Patrick McVey als Sergeant Flamm |
 | Edward Binns als Captain Junket |
 | Ken Lynch als Charley - Chicago Policeman |
| Nora Marlowe als Anna, the Menacing Housekeeper (uncredited) |
| Doreen Lang als Maggie - Thornhill's Secretary (uncredited) |
 | John Beradino als Sergeant Emile Klinger (uncredited) |
 | Ned Glass als Ticket Seller (uncredited) |
 | Tol Avery als State Police Detective (uncredited) |
 | Malcolm Atterbury als Man at Prairie Crossing (uncredited) |
 | Maudie Prickett als Hotel Maid Elsie (uncredited) |
 | Bess Flowers als Plaza Hotel Lounge Patron (uncredited) |
 | Stanley Adams als Lieutenant Harding (uncredited) |
| Andy Albin als Farmer (uncredited) |
| Ernest Anderson als Porter on Twentieth Century Ltd. (uncredited) |
 | Frank Wilcox als Herman Weltner (uncredited) |
| Brandon Beach als Man at Auction (uncredited) |
 | Steve Carruthers als Man at Auction (uncredited) |
 | Taggart Casey als Shaving Man (uncredited) |
| Bill Catching als Auction Attendant (uncredited) |
 | Walter Coy als U.S. Intelligence Agency Official (uncredited) |
| Jimmy Cross als Taxi Driver #1 (uncredited) |
 | Patricia Cutts als Hospital Patient (uncredited) |
| Jack Daly als Train Steward (uncredited) |
| John Damler als Police Lieutenant (uncredited) |
 | Lawrence Dobkin als U.S. Intelligence Agency Official (uncredited) |
| Tommy Farrell als Eddie - Elevator Starter (uncredited) |
 | Jesslyn Fax als Train Passenger (uncredited) |
 | Adolph Faylauer als Bald Bidder (uncredited) |
 | Sally Fraser als Second United Nations Receptionist (uncredited) |
| Paul Genge als Lieutenant Hagerman (uncredited) |
| James Gonzalez als Man at Auction (uncredited) |
| Tom Greenway als Silent State Police Detective (uncredited) |
| Robert Haines als Man at United Nations Building (uncredited) |
| Stuart Hall als Train Passenger (uncredited) |
 | Alfred Hitchcock als Man Who Misses Bus (uncredited) |
 | Stuart Holmes als Hotel Lounge Patron (uncredited) |
 | Eugene Jackson als Security Guard at Auction (uncredited) |
| Bobby Johnson als Waiter (uncredited) |
 | Kenner G. Kemp als Man Leaving Office Building (uncredited) |
 | Madge Kennedy als Mrs. Finlay (uncredited) |
 | Colin Kenny als Man at Auction (uncredited) |
 | Carl M. Leviness als Man at United Nations Building (uncredited) |
 | Alexander Lockwood als Judge Anson B. Flynn (uncredited) |
 | Frank Marlowe als Taxi Driver (uncredited) |
 | Baynes Barron als Taxi Driver #2 (uncredited) |
| Thomas Martin als Train Passenger (uncredited) |
 | James McCallion als Plaza Valet (uncredited) |
| Maura McGiveney als Attendant (uncredited) |
 | Carl Milletaire als Hotel Clerk (uncredited) |
| Hans Moebus als Man at United Nations Building (uncredited) |
 | Howard Negley als Conductor on Twentieth Century, Ltd. (uncredited) |
 | Monty O'Grady als Man at United Nations Building (uncredited) |
| Ralph Reed als Bellhop (uncredited) |
| John Roy als Train Passenger (uncredited) |
 | Jeffrey Sayre als Hotel Lounge Patron / Man at Mt. Rushmore Cafeteria (uncredited) |
 | Scott Seaton als Man at Auction (uncredited) |
| Harry Seymour als Victor - Captain of Waiters (uncredited) |
 | Robert Shayne als Larry Wade (uncredited) |
 | Jeremy Slate als Policeman at Grand Central Station (uncredited) |
 | Olan Soule als Assistant Auctioneer (uncredited) |
 | Helen Spring als Bidder (uncredited) |
 | Harvey Stephens als Stockbroker (uncredited) |
 | Harry Strang als Assistant Conductor (uncredited) |
 | Arthur Tovey als Man at Auction (uncredited) |
 | Dale Van Sickel als Ranger (uncredited) |
| Lloyd Williams als Minor Role (uncredited) |
 | Robert B. Williams als Patrolman Waggoner (uncredited) |
| Paula Winslowe als Woman at Auction (uncredited) |
| Wilson Wood als Photographer at United Nations (uncredited) |
 | Carleton Young als Fanning Nelson (uncredited) |
 | Dick Johnstone als Courtroom Spectator (uncredited) |
| Bert Stevens als Man at United Nations Building (uncredited) |
| Cosmo Sardo als Worker (uncredited) |
| Don Anderson als Worker (uncredited) |
| Alphonso DuBois als Man at United Nations Building (uncredited) |
| Len Hendry als Police Lieutenant (uncredited) |
| Anne Anderson als Woman (uncredited) |
| Rama Bai als Woman at United Nations Building (uncredited) |
| Bernard Herrmann | Original Music Composer |
| Alfred Hitchcock | Director |
| Alfred Hitchcock | Producer |
| Ernest Lehman | Screenplay |
| Ernest Lehman | Author |
| Herbert Coleman | Associate Producer |
| Robert Burks | Director of Photography |
| George Tomasini | Editor |
| Leonard Murphy | Casting |
| Robert F. Boyle | Production Design |
| Van Allen James | Sound Designer |
| Sol Gorss | Stunt Double |
| Bud McNeil | Best Boy Electric |
| Bill Shaw | Gaffer |
| Lee LeBlanc | Special Effects |
| Henry Grace | Set Decoration |
| Sydney Guilaroff | Hairstylist |
| William A. Horning | Art Direction |
| Franklin Milton | Recording Supervision |
| Saul Bass | Title Designer |
| William Tuttle | Makeup Artist |
| A. Arnold Gillespie | Special Effects |
| Edward K. Milkis | Assistant Editor |
| Dale Van Sickel | Stunts |
| Paul Stader | Stunt Coordinator |
| Leonard P. Geer | Stunts |
| Cliff Shirpser | Camera Operator |
| Charles K. Hagedon | Color Timer |
| Merrill Pye | Art Direction |
| James V. King | Camera Operator |
| Frank R. McKelvy | Set Decoration |
| Ruby Rosenberg | Unit Manager |
| Mentor Huebner | Other |
| Bill Catching | Stunts |
| Hubie Kerns | Stunt Double |
| Mickey McCardle | Assistant Director |
| Matthew Yuricich | Visual Effects |
| Tom Overton | Boom Operator |
| Doug Hubbard | Special Effects |
| Bobby Greene | Assistant Camera |
| Kenny Bell | Still Photographer |
| Sam Freed Jr. | Musician |
| Robert Saunders | Assistant Director |
| Bob Hoy | Stunts |
