 | John Travolta als Charlie |
 | Robin Williams als Dan |
 | Kelly Preston als Vicki |
 | Conner Rayburn als Zach |
 | Ella Bleu Travolta als Emily |
 | Lori Loughlin als Amanda |
 | Seth Green als Ralph White |
 | Bernie Mac als Jimmy Lunchbox |
 | Matt Dillon als Yancy Devlin |
 | Dax Shepard als Gary - Child Proofer #1 |
 | Luis Guzmán als Nick - Child Proofer #2 |
 | Ann-Margret als Martha |
 | Rita Wilson als Gloria Lawrence |
 | Justin Long als Troop Leader Adam |
 | Amy Sedaris als Condo Woman |
 | Residente als Tattoo Artist |
 | Sab Shimono als Yoshiro Nishamura |
 | Kevin Yamada als Riku |
 | Kevin Dean-Hackett als Tijuana Priest |
 | Laura Allen als Kelly |
| Sam Travolta als Singing Waiter |
 | Margaret Travolta als Singing Hostess |
 | Nick Loren als Singing Waiter 2 |
 | Kenneth Maharaj als Indian Guy |
| Nova Mejia als Hot Waitress |
 | Margaret Goodman als Grandma |
| Jerome Weinstein als Grandpa |
| Allie Woods Jr. als Old Guy |
 | Michael Enright als Singing Waiter 3 |
 | Alexa Havins als Hot Waitress 2 |
| Keenan Shimizu als Japanese Executive |
 | Akira Takayama als Japanese Executive |
| Shirô Oishi als Japanese Executive |
| Yoshio Mita als Japanese Executive |
| Seiji Kakizaki als Japanese Executive |
| Keisuke Jim Nagahama als Japanese Executive |
| Dominick Riccardi als Driver |
| Costas Panay als Little Kid |
 | Kate Lacey als Rayburn & Reed Employee |
| Denise Violante als Spanish Lady |
| Tonia-Marie Gallo als Lazy Pooch Employee |
 | Chika Kanamoto als Japanese Flight Attendant |
| Marcel Becker als Waiter |
| Alison Pelletier als Hot Waitress 3 |
 | Dylan Sprayberry als Cute Soccer Kid |
 | Bradley Steven Perry als Soccer Kid |
| Joey Pordan als Soccer Kid |
| Jason Davies als Dancer |
| Alicia Mazepa als Dancer |
 | Marielys Molina als Dancer |
| Charlene Smith als Dancer |
| Tera Lee Pollin als Dancer |
| Brendan King als Dancer |
| Jason Dougherty als Dancer |
| Kevin Aubin als Dancer |
 | Christine L. Anderson als Back-Up Singer |
| Crystal MacKenzie als Back-Up Singer |
| Erynn Dickerson als Back-Up Singer |
 | Noel MacNeal als Muppet |
 | John E. Kennedy als Muppet |
 | Matt Vogel als Muppet |
| Josh Cohen als Muppet |
| Bruce Connelly als Muppet |
| Joe Kovacs als Muppet |
 | Tom Woodruff Jr. als Gorilla |
 | DeRay Davis als Zoo Security Guard |
 | Paulo Costanzo als Zoo Maintenance |
| Chris J. Cullen als Pretzel Man (uncredited) |
 | Kendall Draughn als Ice Cream Girl (uncredited) |
| Vohn Ferguson als Pedestrian (uncredited) |
| Steve Ferrarie als Pedestrian (uncredited) |
| Catherine Fetsco als Hot Jogger (uncredited) |
| Gene Harrison als Handyman (uncredited) |
| Ingrid Johnson als Big Tina (uncredited) |
 | Yulia Klass als Restaurant Patron (uncredited) |
 | Heland Lee als Japanese Security Guard #1 (uncredited) |
| Jian Leonardo als Airport Security #3 (uncredited) |
 | Jeffrey Mowery als Commuter (uncredited) |
| Panama Redd als Singing Waiter (uncredited) |
| Hector Rodriguez Jr. als Commuter (uncredited) |
 | Harry L. Seddon als Businessman (uncredited) |
| Melissa Silver als Bartender (uncredited) |
| Lara Anne Slife als Singing Waitress (uncredited) |
 | Frank Tedesco als South Beach Dude (uncredited) |
 | Paul Thornton als Restaurant Patron (uncredited) |
| Nina Vincent als Conga Line Dancer (uncredited) |
| Eden Wright als Girl at Birthday (uncredited) |
| Walt Becker | Director |
| David Diamond | Writer |
| Peter Abrams | Producer |
| Anson Downes | Associate Producer |
| Robert L. Levy | Producer |
| Andrew Panay | Producer |
| Linda Favila | Associate Producer |
| Garrett Grant | Executive Producer |
| Kelly Hayes | Associate Producer |
| Ryan Folsey | Editor |
| Tom Lewis | Editor |
| Kathleen Chopin | Casting |
| Anne McCarthy | Casting |
| Jay Scully | Casting |
| David Gropman | Production Design |
| Brian O'Hara | Art Direction |
| Peter Rogness | Art Direction |
| Ellen Christiansen | Set Decoration |
| Romano C. Pugliese | Set Decoration |
| Joseph G. Aulisi | Costume Design |
| Persefone Karakosta | Makeup Artist |
| Teressia Carter | Hairstylist |
| Trevor Waterson | Production Supervisor |
| David Price | Production Supervisor |
| Diane Rich | Scenic Artist |
| Raymond M. Samitz | Construction Coordinator |
| Odin Benitez | Sound Effects Editor |
| Jeff Cannon | Boom Operator |
| Paul Drenning | ADR & Dubbing |
| Doc Kane | ADR & Dubbing |
| Dan O'Connell | Foley |
| Willard Overstreet | Foley |
| Dan Paikin | Boom Operator |
| Jeff Sawyer | Sound Effects Editor |
| Greg Steele | ADR & Dubbing |
| Debby VanPoucke | Sound Designer |
| Greg Zimmerman | ADR & Dubbing |
| Fred Buchholz | Special Effects Coordinator |
| Roland Blancaflor | Special Effects |
| Rylan Buchholz | Special Effects |
| Tommy Frazier | Special Effects |
| Phil Gauvin | Special Effects |
| Kurt Harris | Special Effects |
| Edward T. Reiff Jr. | Special Effects |
| Bryan Wohlers | Special Effects |
| Akemi Abe | Visual Effects |
| Gayle Busby | Visual Effects Producer |
| Eric D. Christensen | Visual Effects Producer |
| Thomas Clary | Visual Effects Producer |
| Mark Dornfeld | Visual Effects Supervisor |
| Michele Ferrone | Visual Effects Producer |
| Matt Hennessy | Visual Effects |
| Bob Brown | Stunt Coordinator |
| Thomas Robinson Harper | Stunt Coordinator |
| Johnny Martin | Stunt Coordinator |
| Stephen Consentino | Steadicam Operator |
| Larhn Davitt | Grip |
| Peter Bulavinetz | Grip |
| Bernard X. Brongniart | Grip |
| Jack Donnelly | Camera Operator |
| Russell Engels | Gaffer |
| Gavin Fernandez | Loader |
| Timothy Healy | Electrician |
| Bruce MacCallum | Camera Operator |
| Lou Massa | Grip |
| Robert Merk | Electrician |
| Michael J. Prate | Grip |
| Tom Prate | Grip |
| Joe Sarao | Grip |
| Joshua Solson | Electrician |
| Rob Frank | Location Manager |
| Richard Kathlean | Location Scout |
| Tom Lackey | Location Scout |
| Jessica Lichtner | Script Supervisor |
| Eric Papa | Location Scout |
| Chad Schiro | Choreographer |
| Graham Winick | Thanks |
| Jodi Rell | Thanks |
| Jeff Peel | Thanks |
| Charlie Crist | Thanks |
| Jeffrey L. Kimball | Director of Photography |
| Kevin Kaska | Orchestrator |
| Victoria Rose Sampson | Supervising Dialogue Editor |
| Kevin Ladson | Property Master |
| Gregory Lundsgaard | Second Unit Director of Photography |
| Lukasz Jogalla | Second Unit Director of Photography |
| Thomas Robinson Harper | Second Unit Director |
| Johnny Martin | Second Unit Director |
| Elizabeth Kenton | ADR Editor |
| James Sabat | Sound Mixer |
| Scott Blynder | Sound Mixer |
| John Debney | Original Music Composer |
| David Weissman | Writer |
| Todd Kleitsch | Key Makeup Artist |
| Dallas Hartnett | Key Hair Stylist |
| Martina Kohl | Makeup Department Head |
| RaMona Fleetwood | Hair Department Head |
| Susan V. Kalinowski | Hairstylist |
| Nellie Muganda | Makeup Artist |
| Ray McIntyre Jr. | Visual Effects Supervisor |
| Chuck Picerni Jr. | Utility Stunts |
| Joanne Lamstein | Utility Stunts |
| Bernie Mac | In Memory Of |
| Jill Brown | Stunt Double |
| Allan Graf | Stunt Driver |
| Jodi Michelle Pynn | Utility Stunts |
