 | Claudia Cardinale als Jill |
 | Henry Fonda als Frank |
 | Jason Robards als 'Cheyenne' |
 | Charles Bronson als 'Harmonica' |
 | Gabriele Ferzetti als Morton |
 | Paolo Stoppa als Sam |
 | Woody Strode als Frank's Gunman |
 | Jack Elam als Frank's Gunman |
 | Keenan Wynn als Sheriff |
 | Frank Wolff als Brett McBain |
 | Lionel Stander als Innkeeper |
 | Frank Braña als Frank's Gunman (uncredited) |
 | Stefano Imparato als Patrick McBain (uncredited) |
 | Claudio Mancini als Hanged Man (uncredited) |
 | Al Mulock als Frank's Gunman (uncredited) |
| Antonio Palombi als Station Agent (uncredited) |
 | Renato Pinciroli als Bidder (uncredited) |
 | Aldo Sambrell als Cheyenne's Gunman (uncredited) |
 | Conrado San Martín als McBain's Neighbor (uncredited) |
| Enzo Santaniello als Timmy McBain (uncredited) |
| Simonetta Santaniello als Maureen McBain (uncredited) |
| Luana Strode als Cattle Corner Woman (uncredited) |
 | Fabio Testi als Frank's Gunman (uncredited) |
 | Marco Zuanelli als 'Wobbles' (uncredited) |
 | Antonio Molino Rojo als Frank's Gunman (uncredited) |
 | Román Ariznavarreta als Logan (uncredited) |
 | John Frederick als Jim (uncredited) |
 | Aldo Berti als Frank's Gunman (uncredited) |
 | Spartaco Conversi als Frank's Gunman (uncredited) |
| Saturno Cerra als Frank's Gunman (uncredited) |
 | Paolo Figlia als Frank's Gunman (uncredited) |
| Ennio Morricone | Original Music Composer |
| Ennio Morricone | Conductor |
| Tonino Delli Colli | Director of Photography |
| John Landis | Stunts |
| Sergio Leone | Screenplay |
| Sergio Leone | Director |
| Sergio Leone | Story |
| Carlo Simi | Production Design |
| Carlo Simi | Costume Designer |
| Claudio Mancini | Production Manager |
| Nino Baragli | Editor |
| Bino Cicogna | Executive Producer |
| Dario Argento | Story |
| Bernardo Bertolucci | Story |
| Eros Bacciucchi | Special Effects |
| Fulvio Morsella | Producer |
| Sergio Donati | Screenplay |
| Giannetto De Rossi | Makeup Artist |
| Alberto De Rossi | Makeup Supervisor |
| Grazia De Rossi | Hairdresser |
| Mickey Knox | Dialogue |
| Ugo Tucci | Production Supervisor |
| Giancarlo Santi | First Assistant Director |
| Italo Cameracanna | Sound Effects |
| Elio Pacella | Sound Engineer |
| Luciano Anzellotti | Sound Effects |
| Claudio Maielli | Sound Engineer |
| Fausto Ancillai | Sound Engineer |
| Roberto Arcangeli | Sound Effects |
