 | Vera Farmiga als Kate Coleman |
 | Peter Sarsgaard als John Coleman |
 | Isabelle Fuhrman als Esther |
 | CCH Pounder als Sister Abigail |
 | Aryana Engineer als Max Coleman |
 | Jimmy Bennett als Daniel Coleman |
 | Margo Martindale als Dr. Browning |
 | Karel Roden als Dr. Värava |
 | Rosemary Dunsmore als Grandma Barbara |
 | Jamie Young als Brenda |
 | Lorry Ayers als Joyce |
 | Brendan Wall als Detective |
 | Genelle Williams als Sister Judith |
 | Mustafa Abdelkarim als Daniel's Friend #1 |
 | Landon Norris als Daniel's Friend #2 |
 | Julien Elia als Hospital Receptionist |
 | Leni Parker als Delivery Room Nurse |
 | Gemma James Smith als Teacher |
 | Pia Ajango als Saarne Institute Receptionist |
 | Matthew Raudsepp als Saarne Institute Orderly |
 | Sugith Varughese als ICU Doctor |
 | Luis Oliva als ICU Nurse |
 | Ferelith Young als Waiting Room Nurse |
 | Andrew Shaver als Injection Doctor |
| Joel Silver | Producer |
| Ronnie Yeskel | Casting |
| Leonardo DiCaprio | Producer |
| Don Carmody | Executive Producer |
| Steve Lucescu | Stunts |
| John Ottman | Original Music Composer |
| Frederick Howard | Supervising Sound Editor |
| David Barrett | Producer |
| Henning Molfenter | Producer |
| Charlie Woebcken | Producer |
| Sarah Meyer | Producer |
| Ron Bartlett | Sound Re-Recording Mixer |
| Andrea Kenyon | Casting |
| Susan Downey | Producer |
| Steve Richards | Executive Producer |
| Tina Gerussi | Casting |
| Pierre Jodoin | Second Unit Director of Photography |
| Tom Meyer | Production Design |
| Michel Barrière | CG Supervisor |
| Thierry Delattre | Visual Effects Producer |
| Lafleche Dumais | CG Supervisor |
| Daniel Leduc | Visual Effects Producer |
| Richard Martin | CG Supervisor |
| Nicolas-Alexandre Noel | CG Supervisor |
| Pierre Raymond | Visual Effects Producer |
| Philippe Theroux | CG Supervisor |
| Mike Chute | Stunts |
| Jeff Cutter | Director of Photography |
| Jaume Collet-Serra | Director |
| Richard Mirisch | Producer |
| Erik Olsen | Producer |
| Aleksandra Marinkovich | First Assistant Art Direction |
| Timothy Alverson | Editor |
| Hartley Gorenstein | Production Manager |
| Ethan Erwin | Producer |
| Jean Frenette | Stunts |
| Stéphane Lefebvre | Stunts |
| Michael Scherer | Stunts |
| Carolyn A. Loucks | Set Decoration |
| Jan Thijs | Still Photographer |
| David Leslie Johnson-McGoldrick | Screenplay |
| Patrick Rousseau | Sound Mixer |
| David A. Whittaker | Sound Effects Editor |
| Catherine Gourdier | Second Assistant Director |
| Patrick Banister | Art Direction |
| Michael Ireland | Executive Producer |
| David Laramy | Set Decoration |
| Kevin Kelsall | Stunts |
| Christoph Fisser | Producer |
| Ronald Gilbert | Production Manager |
| John Roesch | Foley Artist |
| Jennifer Killoran | Producer |
| Aaron Auch | Producer |
| Alex Mace | Story |
| Stacey Fields | Producer |
| Terel Gibson | First Assistant Editor |
| Alexandre Cadieux | Stunts |
| Randi Wells | Casting |
| Jean-François Dasylva-LaRue | Lighting Technician |
| Antoinette Messam | Costume Design |
| Jeffrey A. Melvin | Assistant Set Decoration |
| Annick Chartier | Key Makeup Artist |
| Mark Freund | Visual Effects Supervisor |
| John Holosko | Aerial Director of Photography |
| Doug Hemphill | Sound Re-Recording Mixer |
| Joseph Bonn | Music Editor |
| Raymond Larose | Set Designer |
| Vincent Gingras-Liberali | Set Designer |
| Félix Larivière-Charron | First Assistant Art Direction |
| Maxime Ferland | Boom Operator |
| Amanda Goodpaster | Music Editor |
| Thomas Nittmann | Visual Effects Producer |
| Edson Williams | Visual Effects Supervisor |
| John Lewin | Chief Lighting Technician |
| Bill R. Dean | Sound Effects Editor |
| Alyson Dee Moore | Foley Artist |
| Susan Marucci | Script Supervisor |
| Bryan Forde | Chief Lighting Technician |
| Doris Simard | Art Department Coordinator |
| Eames Gagnon | Chief Lighting Technician |
| Gaétan Landry | Hairdresser |
| Marco Venditto | Rigging Gaffer |
| Jamie Jones | Stunts |
| Melissa Girotti | Production Coordinator |
| Peter Mathys | Rigging Gaffer |
| Steve Garrad | Visual Effects Producer |
| Corald Giroux | Key Hairdresser |
| Deryck Blake | Property Master |
| Doug Slater | First Assistant Art Direction |
| Peter Muyzers | Visual Effects Production Manager |
| Martine Giguère-Kazemirchuk | Set Decoration |
| Daniel Hamelin | Set Decoration |
| Mary Jo Lang | Foley Mixer |
| Kelli Barksdale | Stunts |
| Kelli Barksdale | Stunt Double |
| Adam Kuhn | Production Executive |
| Stephanie Ingram | Hair Assistant |
| Charles Beetz | Chief Lighting Technician |
| Rafy | Still Photographer |
| Nancy Barker | First Assistant Sound Editor |
| Greg Zenon | First Assistant Director |
| Robert B. Baylis | Key Grip |
| André Valade | Assistant Set Decoration |
| Monty Montgomerie | Key Grip |
| Dave Bouskill | Rigging Gaffer |
| David McKeown | Stunts |
| Pedro Gandol | First Assistant Director |
| Hélène Muller | Production Coordinator |
| Fanny Vachon | Makeup Artist |
| Jean-Pierre Flayeux | CG Supervisor |
| Richard Yuricich | Visual Effects Supervisor |
| Julie Breton | Extras Casting |
| Benoît Mathieu | Location Manager |
| Wayne Godfrey | Costume Set Supervisor |
| Naomi Frenette | Stunts |
| Erik Ajduk | Second Assistant Director |
| Isabelle Faivre-Duboz | Script Supervisor |
| Chuck McCollum | Casting Associate |
| Marie-Soleil Dénommé | Assistant Set Decoration |
| Shawn Roberts | Casting Assistant |
| Emily Fenster | Visual Effects Producer |
| Chad Camilleri | Stunts |
| Tyler Hall | Stunts |
| Christopher Hills-Wright | Assistant Editor |
| Sheila E. Pruden | Costume Supervisor |
| Real Capuano | First Assistant Art Direction |
| Robin Hackl | Visual Effects Supervisor |
| John Moran | First Assistant Art Direction |
| Pete Daprato | Key Rigging Grip |
| Jane Rogers | Extras Casting |
| Angelica Lisk-Hann | Stunts |
| Bernard Larivière | Key Rigging Grip |
| Jean-François Duplat | Second Assistant Director |
| Shaun Magee | Stunts |
| Yanie Salvas | Production Coordinator |
| Carl Kouri | Third Assistant Director |
| Pierre Perrault | Art Direction |
| Isabelle Côté | Graphic Designer |
| Bogdan Zinko | 24 Frame Playback |
| Benoît Sévigny | Chief Lighting Technician |
| Frédéric Chabot | Chief Lighting Technician |
| André Tisseur | Key Rigging Grip |
| Stéphane Pilon | Key Rigging Grip |
| Jeff Scott | Rigging Gaffer |
| Sophie Labrecque | Hairdresser |
| Mélanie Lavoie | Hairdresser |
| Justin Kiang | Casting Assistant |
| Dorothy Crutcher | Assistant Costume Designer |
| Shayna Segal | Stunts |
| Hélèna Laliberté | Stunts |
| Mathilde Gingras | Stunts |
| Tyler Rushton | Stunts |
| Drew Yerys | Assistant Sound Editor |
