 | George Clooney als Jack Foley |
 | Jennifer Lopez als Karen Sisco |
 | Ving Rhames als Buddy Bragg |
 | Don Cheadle als Maurice 'Snoopy' Miller |
 | Steve Zahn als Glenn Michaels |
 | Dennis Farina als Marshall Sisco |
 | Catherine Keener als Adele Delisi |
 | Isaiah Washington als Kenneth |
 | Albert Brooks als Richard Ripley |
 | Luis Guzmán als José 'Chino' Chirino |
 | Viola Davis als Moselle |
 | Jim Robinson als Bank Employee |
| Mike Malone als Bank Customer |
| Donna Frenzel als Bank Teller |
| Manny Suárez als Bank Cop |
 | Keith Hudson als Bank Cop |
| Paul Soileau als Lulu |
| Scott Allen als Pup |
| Susan Hatfield als Parking Lot Woman |
| Brad Martin als White Boxer |
 | James Black als Himey |
 | Wendell B. Harris Jr. als Daniel Burdon |
 | Chuck Castleberry als Library Guard |
 | Chic Daniel als Shock Lock FBI Man |
 | Keith Loneker als White Boy Bob |
 | Connie Sawyer als Old Elevator Lady |
| Philip Perlman als Old Elevator Gent |
 | Paul Calderon als Raymond Cruz |
| Gregory Alpert als Officer Grant |
 | Mark Brown als Ripley Personnel |
| Sandra Ives als Ripley Receptionist |
| Joe Hess als Ripley Guard |
| Betsy Monroe als Waitress |
 | Wayne Pére als Philip |
 | Joe Chrest als Andy |
 | Joe Coyle als Third Ad Guy |
 | Nancy Allen als Midge |
 | Michael Keaton als Ray Nicolette (uncredited) |
 | Samuel L. Jackson als Hejirah Henry (uncredited) |
| Stephen M. Horn als Federal Marshal |
| Oscar A. Diaz als Airport Patron (uncredited) |
 | Jennifer Dorogi als Waitress (uncredited) |
 | Deborah Smith Ford als Airport Passenger (uncredited) |
| Mike Gerzevitz als Xenon Light Guard (uncredited) |
 | Thelma Gutiérrez als Flight Attendant (uncredited) |
 | Wayne V. Johnson als Bank Manager (uncredited) |
 | Pati Lauren als Bank Patron (uncredited) |
| Sherrie Peterson als Shopper (uncredited) |
| Ronnie Stutes als Gas Station Attendant (uncredited) |
| Elmore Leonard | Novel |
| Michael Shamberg | Producer |
| Danny DeVito | Producer |
| Barry Sonnenfeld | Executive Producer |
| John Hardy | Executive Producer |
| Stacey Sher | Producer |
| Elliot Davis | Director of Photography |
| Anne V. Coates | Editor |
| Steven Soderbergh | Director |
| Scott Frank | Screenplay |
| David Holmes | Original Music Composer |
| Bill Corso | Makeup Artist |
| Sean MacKenzie | Digital Compositor |
| Trey Batchelor | Second Assistant Director |
| Gregory Jacobs | First Assistant Director |
| Michael Risoli | Second Second Assistant Director |
| Larry Blake | Sound Re-Recording Mixer |
| Larry Blake | Supervising Sound Editor |
| Mike Malone | Set Dresser |
| Kathy Driscoll-Mohler | Casting |
| Francine Maisler | Casting |
| Gary Frutkoff | Production Design |
| Philip Messina | Art Direction |
| Maggie Martin | Set Decoration |
| Betsy Heimann | Costume Design |
| Margot Boccia | Makeup Artist |
| Bonnie Clevering | Key Hair Stylist |
| Anita Gibson | Makeup Artist |
| Katherine James | Key Makeup Artist |
| Deborah Mills-Whitlock | Hairstylist |
| Waldo Sanchez | Hairstylist |
| David LeRoy Anderson | Makeup Effects Designer |
| Mary L. Mastro | Hairstylist |
| Mark Shostrom | Makeup Artist |
| Frederic W. Brost | Unit Production Manager |
| Pat Chapman | Production Supervisor |
| Caitlin Maloney | Post Production Supervisor |
| Mary Morgan | Production Supervisor |
| David M. Bernstein | Additional Second Assistant Director |
| William D. Robinson | Second Second Assistant Director |
| Shane L. Ashton | Set Dresser |
| Tristan Paris Bourne | Set Dresser |
| Andrea Brody | Art Department Assistant |
| Jon J. Bush | Leadman |
| Lauren Cory | Set Designer |
| Keith P. Cunningham | Set Designer |
| Chuck Eskridge | Standby Painter |
| Emily Ferry | Property Master |
| Harry Frierson | Set Dresser |
| Gary Gagliardo | Construction Foreman |
| Hank Giardina | Paint Coordinator |
| William Gideon | Construction Foreman |
| Brett Gollin | Props |
| Otniel Gonzalez | Assistant Property Master |
| L. David Gordon | Set Dresser |
| Charles Guanci Jr. | Props |
| Blair Huizingh | Art Department Coordinator |
| James E. Hurd Jr. | Set Dresser |
| Steven Kerlagon | Paint Coordinator |
| Alexander Kirst | Set Dresser |
| Chris Patterson | Set Dresser |
| David C. Potter | Leadman |
| Mary Saisselin | Set Designer |
| Chris Snyder | Construction Coordinator |
| Joy Taylor | Assistant Property Master |
| Mark Woodworth | Painter |
| John Blanchard | Carpenter |
| Kurt Braun | Set Dresser |
| Tammy DeRuiter | Painter |
| Michael Hendrick | Greensman |
| Guy Hietala | Painter |
| Al Hobbs | Set Designer |
| Michael A. Johnson | Set Dresser |
| Patrick McGuire | Set Dresser |
| Harry E. Otto | Set Designer |
| Jeremy Alan Read | Set Dresser |
| Kathleen A. Runey | Swing |
| Fred Schwendel | Set Dresser |
| Jimmy Armstrong | Utility Sound |
| David Betancourt | Foley Mixer |
| Gail Carroll-Coe | Utility Sound |
| Carrie Cashman | Foley Recordist |
| Mike Chock | Dialogue Editor |
| John Dunn | Foley Editor |
| Ezra Dweck | Foley Editor |
| Dawn Fintor | Foley Artist |
| Eric Flickinger | Sound Recordist |
| Aaron Glascock | Sound Editor |
| Mark C. Grech | Utility Sound |
| Paul Ledford | Production Sound Mixer |
| Gerry Lentz | Sound Re-Recording Mixer |
| Oscar Mitt | Assistant Sound Editor |
| Jerry Rose | Utility Sound |
| Sam Sarkar | Utility Sound |
| Alicia Stevenson | Foley Artist |
| Paul Stevenson | Foley Artist |
| Marvin Walowitz | Dialogue Editor |
| Keenan Wyatt | Boom Operator |
| Detlef Halaski | ADR Mixer |
| Ryan Arndt | Special Effects |
| Craig Tex Barnett | Special Effects |
| Derrick Crane | Special Effects |
| Don Gray | Special Effects |
| Don Hastings | Special Effects |
| Scott Hastings | Special Effects |
| Darrell Roberts | Special Effects |
| Eric Roberts | Key Special Effects |
| Mike Sasgen | Special Effects |
| Larry M. Shorts | Special Effects |
| Dieter Sturm | Special Effects |
| Carol Wenger | Special Effects |
| Cliff Wenger | Special Effects |
| Gunter Anderson | Special Effects Technician |
| Michael Kelly | Special Effects Technician |
| David K. Nami | Special Effects Technician |
| Creig Symons | Special Effects |
| Erin M. Cullen | Rotoscoping Artist |
| Chris Del Conte | Visual Effects Producer |
| Gilbert Gonzales | Rotoscoping Artist |
| Karen Klein | Roto Supervisor |
| Brad Kuehn | Visual Effects Supervisor |
| Will McCoy | Digital Compositor |
| Allen Ruilova | Animation |
| Brian Shows | Visual Effects Technical Director |
| G. A. Aguilar | Stunt Coordinator |
| Robert Apisa | Stunts |
| Bruce Paul Barbour | Stunts |
| Jill Brown | Stunts |
| Carl Ciarfalio | Stunts |
| Douglas Crosby | Stunts |
| Malcolm Ian Cross | Stunts |
| Richard Drown | Stunts |
| Ousaun Elam | Stunts |
| Peter Epstein | Stunts |
| Eddie J. Fernandez | Stunts |
| Ramiro González | Stunts |
| Dick Hancock | Stunts |
| Chuck Jeffreys | Stunts |
| Daniel Maldonado | Stunts |
| Steve Martinez | Stunts |
| Bennie Moore | Stunts |
| Jim Palmer | Stunts |
| Peewee Perez | Stunts |
| Peewee Piemonte | Stunts |
| Stephen A. Pope | Stunts |
| Victor Prince | Stunts |
| Thomas Rosales Jr. | Stunts |
| Hashem Shaalan | Stunts |
| Garfield Wedderburn | Stunts |
| Brian J. Williams | Stunts |
| Gene Williams | Stunts |
| Blaise Corrigan | Stunts |
| Ned Corrigan | Stunt Driver |
| Eddie J. Fernandez | Stunt Double |
| Chuck Jeffreys | Stunt Double |
| Alex Madison | Stunts |
| Brad Martin | Stunt Double |
| Eddie Perez | Stunts |
| Felipe Savahge | Utility Stunts |
| Al Whiting | Stunts |
| Wilma Garscadden-Gahret | Script Supervisor |
| Anita Camarata | Music Supervisor |
| David Jensen | Grip |
