 | Charlie Hunnam als Raleigh Becket |
 | Rinko Kikuchi als Mako Mori |
 | Idris Elba als Stacker Pentecost |
 | Max Martini als Herc Hansen |
 | Clifton Collins Jr. als Tendo Choi |
 | Ron Perlman als Hannibal Chau |
 | Charlie Day als Dr. Newton Geiszler |
 | Burn Gorman als Dr. Hermann Gottlieb |
 | Robert Kazinsky als Chuck Hansen |
 | Robert Maillet als Lt. Aleksis Kaidanovsky |
 | Heather Doerksen als Lt. Sasha Kaidanovsky |
 | Larry Joe Campbell als Tommy T |
 | Brad William Henke als Miles |
 | Diego Klattenhoff als Yancy Becket |
 | Santiago Segura als Wizened Man |
 | Jane Watson als Raleigh and Yancy's Mom |
 | Jung-Yul Kim als Hannibal Chau Thug |
 | Joshua Peace als Officer |
 | Mana Ashida als Young Mako |
 | Joe Pingue als Captain Merrit |
 | Milton Barnes als McTighe |
 | Brian Frank als 1st Officer |
 | Ellen McLain als Gipsy Danger AI (voice) |
 | David Fox als Old Man on Beach |
 | Jake Goodman als Child |
 | Robin Thomas als American UN Representative |
| Julian Barnes als British UN Representative |
 | David Richmond-Peck als Canadian UN Representative |
 | Sebastian Pigott als Engineer |
| J.C. Kenny als TV Reporter |
 | Robert Morse als Raleigh and Yancy's Dad |
 | Mike Chute als Saltchuck Crew |
 | Duncan McLeod als Saltchuck Crew |
 | Louis Paquette als Saltchuck Crew |
 | Matthew G. Taylor als Saltchuck Crew |
| Frank Nakashima als UN Representative |
| Terry Belleville als UN Representative |
| Farzad Sadrian als UN Representative |
 | Mishu Vellani als UN Representative |
| Clive Walton als UN Representative |
| Peter Kosaka als Young Mako's Father |
| Yiren Stark als Young Mako's Mother |
 | Mark Luu als Wei Tang Triplet |
 | Charles Luu als Wei Tang Triplet |
 | Lance Luu als Wei Tang Triplet |
| Willie Wong als Engineer (uncredited) |
 | Simu Liu als Extra (uncredited) |
 | Victoria Sawal als Chinese Girl in Anti-Kaiju Refuge |
| David Cronenberg | Thanks |
| Guillermo Navarro | Director of Photography |
| Scott Martin Gershin | Sound Designer |
| Scott Martin Gershin | Supervising Sound Editor |
| Andrew Neskoromny | Production Design |
| Margery Simkin | Casting |
| Richard L. Johnson | Supervising Art Director |
| Carol Spier | Production Design |
| Catherine Harper | Foley Artist |
| Christopher Moriana | Foley Artist |
| Laird McMurray | Special Effects Coordinator |
| Peter Amundson | Editor |
| Clay Pinney | Special Effects Supervisor |
| Elinor Rose Galbraith | Supervising Art Director |
| Guillermo del Toro | Screenplay |
| Guillermo del Toro | Director |
| Guillermo del Toro | Producer |
| Raúl Monge | Concept Artist |
| Callum Greene | Executive Producer |
| Callum Greene | Unit Production Manager |
| Robin D. Cook | Casting |
| Colin Penman | Key Makeup Artist |
| Ramin Djawadi | Original Music Composer |
| Alan G. Kelly | Second Assistant Camera |
| Thomas Tull | Producer |
| Jon Jashni | Producer |
| John Gilroy | Editor |
| Tom Morello | Musician |
| Wayne D. Barlowe | Concept Artist |
| Travis Beacham | Screenplay |
| Travis Beacham | Story |
| Stephen Coleman | Orchestrator |
| Mary Parent | Producer |
| Simon Webber | Concept Artist |
| Bradley James Allan | Fight Choreographer |
| Pipsan Ayotte | Key Makeup Artist |
| Kate Hawley | Costume Design |
| Sandi Tanaka | Art Direction |
| Nerses Gezalyan | Foley Mixer |
| James Moriana | Foley Artist |
| Jeffrey Wilhoit | Foley Artist |
| Vladislav Fedorov | Set Designer |
| Jordan Samuel | Makeup Department Head |
| Peter Nicolakakos | Set Decoration |
| Michelle Russell | Unit Production Manager |
| Jeremy Gillespie | Second Assistant Art Director |
| Gary A. Hecker | Foley Artist |
| C.J. Roy | Digital Imaging Technician |
| Gilles Corbeil | Steadicam Operator |
| Kerry Hayes | Still Photographer |
| Francisco Ruiz Velasco | Concept Artist |
| Anton Van Rooyen | Camera Operator |
| Andrew Li | Art Direction |
| Peter Bodnarus | Set Designer |
| Andra Totirescu | Set Designer |
| Yasmyn Lee | Second Assistant Art Director |
| Christopher Geggie | Property Master |
| Phillip Tellez | Supervising Carpenter |
| Jason McFarling | Cableman |
| Fred Kamping | Location Manager |
| Gary Marullo | Foley Artist |
| Dug Rotstein | Script Supervisor |
| Gregg Rudloff | Sound Re-Recording Mixer |
| John T. Reitz | Sound Re-Recording Mixer |
| George Chavez | Color Timer |
| Margit Pfeiffer | Dialogue Editor |
| Tim Walston | Sound Effects Editor |
| David Best | Assistant Art Director |
| Carlos Caneca | Leadman |
| Stefany Koutroumpis | Second Assistant Art Director |
| Michael L. Hall | Chief Lighting Technician |
| Humberto Garcia | Set Designer |
| Tim LeBlanc | Sound Re-Recording Mixer |
| James W. Harrison III | First Assistant Editor |
| Shane B. Scott | Script Supervisor |
| John H. Han | CG Supervisor |
| Perry Hoffman | Camera Operator |
| William Cheng | Set Designer |
| Angelo Colavecchia | Camera Operator |
| David G. Fremlin | Set Designer |
| Ron Hewitt | Property Master |
| James E. Price | Visual Effects Supervisor |
| John Knoll | Visual Effects Supervisor |
| Nigel Sumner | Visual Effects Supervisor |
| Wendy Wong | Aerial Coordinator |
| George Wong | Assistant Location Manager |
| Ryan Murphy | Mix Technician |
| Gary Deneault | Assistant Chief Lighting Technician |
| Becky Sullivan | ADR Supervisor |
| Dan Hegeman | Sound Effects Editor |
| Wendy Chesebrough Lowe | Visual Effects Coordinator |
| Peter Myles | Music Editor |
| Adam Ohl | Digital Intermediate Producer |
| Peter Zinda | Sound Effects Editor |
| Teresa Buccione | Key Hair Stylist |
| Cliona Furey | Assistant Hairstylist |
| Itsuko Kurono | Assistant Art Director |
| Kevin Haeberlin | Leadman |
| Erik Kaufmann | Digital Intermediate Editor |
| Nadia Venesse | Dialect Coach |
| Daniel Perez Ferreira | VFX Artist |
| Jason Heapy | Visual Effects Producer |
| Johnny Wang Yin-Ming | Location Manager |
| Stephen P. Robinson | Sound Effects Editor |
| Paul R.J. Elliot | Hair Department Head |
| Brad Milburn | Set Designer |
| Patricia Larman | Leadman |
| Scott Wolf | Sound Effects Editor |
| David Stanke | First Assistant Sound Editor |
| Joe Everett | Unit Publicist |
| David Meng | Concept Artist |
| Tom Starnes | Chief Lighting Technician |
| Elaine Thurston | Production Controller |
| Andrew Redekop | Assistant Art Director |
| Joe Curtin | Construction Coordinator |
| Ciara Brennan | Costume Set Supervisor |
| Hal Hickel | Animation Supervisor |
| Alain Moussi | Stunts |
| Jon Bowen | Compositing Supervisor |
| Lauren Hadaway | ADR Editor |
| Erik Classen | Compositors |
| Scott F. Johnston | Visual Effects |
| Brian N. Bentley | Compositors |
| Weicheng Jiang | Visual Effects |
| Chris Lentz | Animation Supervisor |
| Hui Ling Chang | Visual Effects Production Manager |
| Ryan Hopkins | CG Supervisor |
| Yuhon Ng | Digital Effects Supervisor |
| David Meny | CG Supervisor |
| Ryan Reed | Hairstylist |
| Paul Jefferson | Supervising Carpenter |
| Renee Fontana | Costume Supervisor |
| Csaba Wagner | Sound Effects Editor |
| Greg Hyman | Visual Effects Editor |
| Erin D. O'Connor | Visual Effects Producer |
| Marie-Claude Harnois | Production Coordinator |
| D.J. Carson | Unit Production Manager |
| Christopher Raucamp | First Assistant Camera |
| Alan Zielonko | Boom Operator |
| Masanobu 'Tomi' Tomita | Foley Editor |
| Johnny Askwith | Camera Operator |
| Glen Gauthier | Sound Mixer |
| Troy P. Liddell | Choreographer |
| Rocco Larizza | Special Effects Supervisor |
| Mark Cyre | First Assistant Camera |
| Joseph Micomonaco | First Assistant Camera |
| Cam McLauchlin | Assistant Editor |
| Alison O'Brien | Visual Effects Producer |
| Patricia Keighran | Key Makeup Artist |
| Lara Khachooni | Assistant Editor |
| Andrew Kinney | Orchestrator |
| David Lee | Chief Lighting Technician |
| Bernie Lalonde | Key Rigging Grip |
| Steve Bobertz | First Assistant Editor |
| TyRuben Ellingson | Concept Artist |
| Simon Lee | Concept Artist |
| Rob McCallum | Storyboard Artist |
| Gareth Wilson | Set Dresser |
| Guy Davis | Concept Artist |
| Steve Switzer | Boom Operator |
| Rudy Braun | Set Designer |
| Keith Thompson | Concept Artist |
| Oscar Chichoni | Concept Artist |
| Elspeth Cassar | Production Coordinator |
| Rick Stribling | Key Grip |
| Mo Henry | Negative Cutter |
| Charlie Campagna | Sound Effects Editor |
| Darrin Mann | Foley Mixer |
| Jeff Sutherland | Compositing Supervisor |
| Courtenay Bainbridge | Assistant Production Coordinator |
| Ryan Cunningham | Visual Effects Coordinator |
| John Colavecchia | Camera Operator |
| Andy Jekabsons | First Assistant Camera |
| Benjamin Smith | First Assistant Camera |
| Shamu Naidu | Assistant Accountant |
| Sorin Popescu | Set Designer |
| Matt McFarland | Digital Intermediate |
| Brigitte Rabazo | Assistant Editor |
| Harold Gay | Assistant Art Director |
| Jonathan Pencharz | Assistant Production Coordinator |
| Karl Denniston Brown | Set Dresser |
| Toni Wong | Set Dresser |
| Tony Blondal | Orchestrator |
| J. Ryan Halpenny | Second Assistant Art Director |
| Phil Whitfield | Assistant Chief Lighting Technician |
| Jeff Smith | Second Assistant Art Director |
| Debbie Van Dusen | Assistant Accountant |
| Lincoln D'Souza | Assistant Accountant |
| Wing Ma | Key Grip |
| Corinna Schmitt-Porsia | Second Assistant Art Director |
| Roslyn Hanchard | Assistant Costume Designer |
| Victor Schutz | CG Supervisor |
| Doug Williams | Concept Artist |
| Russell Moore | Set Designer |
| John Moran | Assistant Art Director |
| Thomas J. O'Connell | ADR Mixer |
| Robert Daprato | Key Grip |
| Stephen Schirle | Concept Artist |
| Zachary Tucker | Visual Effects Supervisor |
| Kevin Lise | On Set Props |
| Colin Adams | Set Dresser |
| Brett Voss | Foley Mixer |
| Zameret Kleiman | Extras Casting |
| Allen Williams | Concept Artist |
| Craig Baker | Cableman |
| Fangfei Li | Digital Compositor |
| Russell Lum | Visual Effects Production Manager |
| Lindy DeQuattro | Visual Effects Supervisor |
| Sondra Treilhard | Key Hair Stylist |
| Matt Middleton | Set Designer |
| Jon Hunter | Assistant Art Director |
| Pat Conran | CG Supervisor |
| Jeff DaSilva | Second Assistant Camera |
| Maxine Gervais | Digital Intermediate Colorist |
| Danielle Rubin | Visual Effects Production Manager |
| Derrick Carlin | Animation Supervisor |
| Jim Holmes | Best Boy Grip |
| Christopher Dean | Key Grip |
| Kyla McFeat | Assistant Accountant |
| Julia Seidman | Second Assistant Camera |
| Amanda Wojtaszek | Second Assistant Camera |
| Bobbie Shay | Post Production Assistant |
| Tim Belsher | CG Supervisor |
| David Lylloff | Set Dresser |
| Peter Gmehling | 24 Frame Playback |
| Sandra Lombardi | Digital Imaging Technician |
| John Saysana | First Assistant Camera |
| James Banfield | Lighting Technician |
| Pierre Berube | Rigging Gaffer |
| Tara Dixit | Second Assistant Camera |
| Stephan Maia | Second Assistant Camera |
| Michele Harney | Costume Set Supervisor |
| Lara Alexander | Assistant Accountant |
| Gerry Alfonso | Assistant Accountant |
| Katharine Boyce | Assistant Accountant |
| Stephanie Massarella | Assistant Accountant |
| Valerie Phillips | Assistant Accountant |
| Erin Renton | Assistant Accountant |
| Candace Tempelmeyer | Assistant Accountant |
| Kevin Michael Schembri | Assistant Accountant |
| Scott Perry | Dialogue Coach |
| Man Fong | Production Accountant |
| Christian Dendias | Production Assistant |
| Vicki Henton | Production Assistant |
| Adam Meaden | Production Assistant |
| Sam Rosati | Production Assistant |
| Emma Tamblyn | Production Assistant |
| Fermin Balado | Production Assistant |
| Brandon Balon | Production Assistant |
| Jonah Greisman | Production Assistant |
| Christopher Lori | Production Assistant |
| Feyon Li | Production Coordinator |
| Lucia Haliburton | Production Secretary |
| Jane Spencer | Extras Casting Assistant |
| Jade E. Chatham | Assistant Editor |
| Lauren Brandon | Post Production Assistant |
| Mark McFadden | Assistant Location Manager |
| Luke Vallee | Digital Compositor |
| Alex Nice | Matte Painter |
| Javier Jimenez | Visual Effects Producer |
| Daniel Cavey | Visual Effects Production Manager |
| Brian Claus | Animatronics Designer |
| Thomas Hayek | Sound Mixer |
| Joanne Jackson | Production Manager |
| Dustin Bernard | Unit Production Manager |
| Joelle Craven | Assistant Art Director |
| Timothy Peel | Assistant Art Director |
| Hugo Martin | Concept Artist |
| Carlos Salgado | Concept Artist |
| Sang Maier | Props |
| Barbara Agbaje | Second Assistant Art Director |
| George Cribb | Set Dresser |
| Sarah Gardner | Set Dresser |
| John Mainwaring | Set Dresser |
