 | Robin Williams als Hunter "Patch" Adams |
 | Monica Potter als Carin Fisher |
 | Philip Seymour Hoffman als Mitch Roman |
 | Daniel London als Truman Schiff |
 | Bob Gunton als Dean Walcott |
 | Harve Presnell als Dean Anderson |
 | Peter Coyote als Bill Davis |
 | Michael Jeter als Rudy |
 | Josef Sommer als Dr. Eaton |
 | Irma P. Hall als Joletta |
 | Barry Shabaka Henley als Emmet |
 | Frances Lee McCain als Judy |
 | Daniella Kuhn als Adelane |
 | James Greene als Bile |
 | Harold Gould als Arthur Mendelson |
 | Bruce Bohne als Trevor Beene |
 | Harry Groener als Dr. Prack |
| Steven Anthony Jones als Charlie |
 | Richard Kiley als Dr. Titan |
 | Douglas Roberts als Larry |
 | Ellen Albertini Dow als Aggie |
 | Alan Tudyk als Everton |
 | Ryan Hurst als Neil |
| Peter Siteri als Chess Man |
 | Don West als Instructor |
 | Greg Sestero als Jaime |
| Jason Aaron Baca als Patch Pirate |
 | Ismael 'East' Carlo als Hispanic Father |
| Diane Amos als Older Waitress |
 | Andy Arness als Orderly (uncredited) |
| Renee Rogers als Receptionist |
 | Dot-Marie Jones als Miss Meat |
| Debra Zane | Casting |
| Phedon Papamichael | Director of Photography |
| Linda DeScenna | Production Design |
| Steve Oedekerk | Screenplay |
| Tom Shadyac | Director |
| Scott Hill | Visual Effects Editor |
| Judy L. Ruskin | Costume Design |
| Marc Shaiman | Original Music Composer |
| Barry Kemp | Producer |
| Jeff Carson | Music Supervisor |
| Patrick Loungway | Camera Operator |
| Charles Newirth | Producer |
| Don Zimmerman | Editor |
| James Nedza | Art Direction |
| Ric McElvin | Set Decoration |
| Cheri Minns | Makeup Artist |
| Michael Hilkene | Supervising Sound Editor |
| Odin Benitez | Sound Effects Editor |
| Randall Guth | Sound Effects Editor |
| Patch Adams | Novel |
| Mike Farrell | Producer |
| Marvin Minoff | Producer |
| Rafael E. Sánchez | Gaffer |
| David Blitstein | Special Effects Coordinator |
| Gaston Biraben | Dialogue Editor |
| Jeff Atmajian | Orchestrator |
| Julia Frey | Visual Effects Producer |
| Christopher T. Welch | ADR Editor |
| Paul Sanchez | First Assistant Camera |
| Mindy Hall | Makeup Artist |
| Melinda Sue Gordon | Still Photographer |
| Hallie D'Amore | Makeup Artist |
| Dan O'Connell | Foley Artist |
| Piero Mura | Sound Effects Editor |
| John T. Cucci | Foley Artist |
| Avram D. Gold | Dialogue Editor |
| Guy T. Wiedmann | Visual Effects Editor |
| Jenny Fulle | Visual Effects Producer |
| Sheena Duggal | Visual Effects Supervisor |
| Judith A. Cory | Key Hair Stylist |
| Sam Richards | CG Supervisor |
| Kim Marks | Camera Operator |
| Karyn Huston | Hairstylist |
| Butch West | Construction Coordinator |
| Catherine Childers | Hairstylist |
| Carol DePasquale | Script Supervisor |
| Gary Dahlquist | Rigging Gaffer |
| Mary C. Lane | Costume Supervisor |
| Ashley Fardys | Art Department Coordinator |
| Beau Bonneau | Casting |
| Kim Petrosky | Casting |
| Nancy Servin | Seamstress |
| Frank Bennett | Orchestrator |
| Patrick McArdle | First Assistant Camera |
| Daryl Tucker | Electrician |
| Kirk A. Holland | Transportation Co-Captain |
