 | Seth Rogen als Dale Denton |
 | James Franco als Saul Silver |
 | Gary Cole als Ted |
 | Danny McBride als Red |
 | Rosie Perez als Carol |
 | Kevin Corrigan als Budlofsky |
 | Craig Robinson als Matheson |
 | Amber Heard als Angie Anderson |
 | Ed Begley Jr. als Robert |
 | Nora Dunn als Shannon |
 | Bobby Lee als Bobby |
 | James Remar als General Bratt |
 | Joe Lo Truglio als Mr. Edwards |
 | Art Napiontek als Clark |
 | Cleo King als Police Liaison Officer |
 | Bill Hader als Private Miller |
 | Jonathan Spencer als Scientist |
 | Dana Lee als Cheung |
 | Ken Jeong als Ken |
 | David C. Cook als Chris Gebert |
| Howard S. Lefstein als Mark |
 | Connie Sawyer als Faye Belogus |
| David McDivitt als Cop with Mole |
 | Mae LaBorde als Mrs. Mendelson |
| Kendall Carly Browne als Old Woman |
| George Lew als Old Man |
| John Robert Tramutola als Walt |
| Adam Crosby als Ack |
| Andrew Heald als Blake |
 | Jeannetta Arnette als Sandra Danby |
| Carlos Aleman als Guy in Car |
 | Omar Leyva als Guy in Car #2 |
| Sam Carson als Xerox Secretary |
 | Jack Kehler als Walter - Accountant |
 | Robert Longstreet als Dr. Terrence |
 | Peter Gray Lewis als Thug #1 - Peter |
 | Steve Bannos als Thug #2 - Jared |
 | Eddie Rouse als Thug #5 - Lance |
| Mark Whigham als Thug #3 |
 | Brian Scannell als Thug |
 | Troy Gentile als Troy (uncredited) |
| Jourdan Lee als Assassin (uncredited) |
| John Dunn | Costume Design |
| Seth Rogen | Story |
| David Gordon Green | Director |
| Judd Apatow | Story |
| Kerry Barden | Casting |
| Judd Apatow | Producer |
| Shauna Robertson | Producer |
| Evan Goldberg | Story |
| Evan Goldberg | Screenplay |
| Seth Rogen | Executive Producer |
| Tim Orr | Director of Photography |
| Seth Rogen | Screenplay |
| Evan Goldberg | Executive Producer |
| Craig Alpert | Editor |
| Billy Hopkins | Casting |
| Suzanne Smith Crowley | Casting |
| Chris L. Spellman | Production Design |
| Gary Hymes | Stunt Coordinator |
| Mike Smith | Stunt Coordinator |
| Colin Patton | First Assistant Editor |
| Graeme Revell | Original Music Composer |
| Michael O'Farrell | Sound Re-Recording Mixer |
| George H. Anderson | Supervising Sound Editor |
| Soo-Jin Yoon | Key Hair Stylist |
| Darren Michaels | Still Photographer |
| Bob Kensinger | Set Decoration |
| Ronit Ravich-Boss | Script Supervisor |
| David Giammarco | Sound Re-Recording Mixer |
| Melissa Yonkey | Hair Department Head |
| Jonathan Karp | Music Supervisor |
| Cindy Marty | Sound Effects Editor |
| Tom Carson | Production Coordinator |
| Christof Gebert | Production Sound Mixer |
| James Matheny | Dialogue Editor |
| Bruce Lacey | Foley Editor |
| Kyle Rochlin | Foley Mixer |
| Vincent Guisetti | Foley Artist |
| Jonathan Karp | Music Editor |
| Michael Haight | Dialogue Editor |
| Howard London | ADR Mixer |
| Larry Kemp | Supervising ADR Editor |
| Pamela Kahn | Foley Artist |
| Peter Dress | Second Second Assistant Director |
| Dara Weintraub | Co-Producer |
| Gary Hymes | Second Unit Director |
| Dara Weintraub | Unit Production Manager |
| Lisa C. Satriano | First Assistant Director |
| Lisa M. Rowe | Second Assistant Director |
| Marc Dabe | Art Direction |
| Kimberly Greene | Makeup Supervisor |
| Erin Wooldridge | Key Makeup Artist |
| Cheryl Eckert | Hairstylist |
| Laura Albert | Stunts |
| Gary Baxley | Stunts |
| Mark Chadwick | Stunts |
| Corey Michael Eubanks | Stunts |
| Debbie Evans | Stunts |
| Dane Farwell | Stunts |
| Sean Graham | Stunts |
| Collin Hymes | Stunts |
| Yoshio Iizuka | Stunts |
| Hiro Koda | Stunts |
| Paul Leonard | Stunts |
| Ray Lykins | Stunts |
| Tom McComas | Stunts |
| Ed McDermott II | Stunt Driver |
| Scotty Richards | Stunt Driver |
| Jimmy Romano | Stunts |
| David Wald | Stunts |
| Nick Satriano | Second Unit First Assistant Director |
| Christa Vausbinder | Production Supervisor |
| Michelle Spears | Property Master |
| Lawrence Karman | Camera Operator |
| Lawrence Karman | Steadicam Operator |
| Bill Coe | First Assistant Camera |
| Bobby McMahan | Second Assistant Camera |
| Matthew A. Petrosky | "B" Camera Operator |
| Sean Hunter Moe | First Assistant "B" Camera |
| Linda Källérus | Second Assistant "B" Camera |
| Phyllis Corcoran-Woods | Costume Supervisor |
| Brenda M. Ware | Key Costumer |
| Myron Baker | Costumer |
| Lorraine Crossman | Costumer |
| Chris Napolitano | Chief Lighting Technician |
| Ron Alexus | Assistant Chief Lighting Technician |
| Kevin J. Lang | Rigging Gaffer |
| Walter 'Bud' Scott | Key Grip |
| Coleman L. Hart | Best Boy Grip |
| Greg Brooks | Dolly Grip |
| Steven A. Guerrero | Dolly Grip |
| William Ambrose | Key Rigging Grip |
| Knox White | Boom Operator |
| Lydia Hollyfield | Utility Sound |
| John Frazier | Special Effects Supervisor |
| Eric Rylander | Special Effects Coordinator |
| Christine Bonnem | Location Manager |
| Jeffrey Garrett | Assistant Location Manager |
| Matt V. Messina | Assistant Location Manager |
| Jonathan Lynch | Assistant Location Manager |
| Carrie Arnold | Assistant Production Coordinator |
| Justin Giugno | Production Secretary |
| Jill Rosenblatt | Production Accountant |
| Ricky Cuevas | Assistant Accountant |
| Rob Meisenholder | Assistant Accountant |
| Karen Higgins | Construction Coordinator |
| Robert Fechtman | Assistant Art Director |
| Ryan Falkner | Storyboard Artist |
| Kat Wilson | Art Department Coordinator |
| Thierry Labbe | Leadman |
| Martin Milligan | Set Dresser |
| Kim Richey | Assistant Property Master |
| Kym Langlie | Unit Publicist |
| Paul Schnee | Casting Associate |
| Jennifer Ricchiazzi | Casting Associate |
| Chris Bustard | Extras Casting |
| John Orlebeck | Transportation Coordinator |
| Don Poole | Transportation Captain |
| Buzz Feitshans IV | Second Unit Director of Photography |
| Tim Mirkovich | Additional Editing |
| Ray Neapolitan | Assistant Editor |
| Michael O'Farrell | Supervising Sound Editor |
| Joe Schiff | Assistant Sound Editor |
| Bill Burns | Assistant Sound Editor |
| Graeme Revell | Conductor |
| Tim Simonec | Orchestrator |
| Dominik Hauser | Orchestrator |
| Peter Boyer | Orchestrator |
| Mo Henry | Negative Cutter |
| J.J. Perry | Stunts |
