 | Adam Sandler als Sam Brenner |
 | Kevin James als President 'Chewie' Cooper |
 | Michelle Monaghan als LTC Violet Van Patten |
 | Peter Dinklage als Eddie 'The Fire Blaster' Planz |
 | Josh Gad als Ludlow 'The Wonder Kid' Lamensoff |
 | Matt Lintz als Matty Van Patten |
 | Brian Cox als Admiral Porter |
 | Denis Akiyama als Professor Iwatani |
 | Sean Bean als Corporal Hill (SAS Officer) |
 | Jane Krakowski als First Lady Jane Cooper |
 | Dan Aykroyd als 1982 Championship MC |
 | Affion Crockett als Sergeant Dylan Cohan |
 | Lainie Kazan als Mickey Lamonsoff |
 | Ashley Benson als Lady Lisa |
 | Tom McCarthy als Michael the Robot |
 | Tim Herlihy als Defense Secretary |
 | Jackie Sandler als President's Assistant Jennifer |
 | Jared Sandler als White House Junior Aide Jared |
 | William S. Taylor als Navy Secretary |
 | Rose Rollins als White House Press Secretary |
 | Tucker Smallwood als CIA Chief |
 | Serena Williams als Serena Willams |
 | Martha Stewart als Martha Stewart |
 | Allen Covert als Abusive Citizen |
 | Bill Lake als NY Police Commissioner |
 | Mark Whelan als Colonel Devereux |
 | Dan Patrick als White House Reporter #1 |
 | Robert Smigel als White House Reporter #2 |
| Steve Koren als White House Reporter #3 |
 | Sadie Sandler als Lemonadie Sadie |
 | Sunny Sandler als Sweet Scout Girl |
| Hannah Covert als Arcader Choir Girl |
| Abigail Covert als Classroom Scout Girl |
| Sienna James als Classroom Scout Girl |
| Shea James als Classroom Scout Girl |
 | Chris Titone als Soccer Player |
 | Jonathan Loughran als White House Gate Guard |
 | Toru Iwatani als Electric Dream Factory Repairman |
 | Anthony Ippolito als 13-Year Old Brenner |
| Jared Riley als 13-Year Old Cooper |
| Andrew Bambridge als 13-Year Old Eddie |
| Jacob Shinder als 8-Year Old Ludlow |
 | Jack Fulton als Little Boy on London Street |
| Kevin Grady als Samurai Gamer |
 | Bridget Graham als Cyber Chick |
 | Jocelyn Hudon als Cyber Chick |
 | Margaret Killingbeck als Old Woman in London Apartment |
 | Ron Mustafaa als Indian Teenage Boy |
 | Meher Pavri als Indian Teenage Girl |
 | Annika Pergament als News Reporter |
| Lamont James als Seal |
 | James Preston Rogers als Seal |
| Bola Olubowale als Seal |
 | Rob Archer als Seal |
 | Mark Sparks als Fighter Pilot |
| Steve Wiebe als DARPA Scientist |
 | Sara Haines als TV News Anchor |
 | Derwin Philips als Secret Service Man |
 | Michael Boisvert als Secret Service Man |
 | Colleen Reynolds als Abusive Citizen |
 | Jimi Shlag als Abusive Citizen |
| Emily Jenkins als Abusive Citizen |
| Sistah Lois als Sergeant Cohan's Mother |
| Andrew McMichael als Arcade Employee |
| Gary Douglas als DC Valet |
| Eric Trask als Warden |
| Susie McLean als Press Person |
 | Daryl Hall als Daryl Hall |
 | John Oates als John Oates |
 | Matt Frewer als Max Headroom (voice) |
 | Billy West als Additional Character Voice (voice) |
| Holly Beavon als Additional Character Voice (voice) |
 | Fiona Shaw als Prime Minister (uncredited) |
 | Nick Swardson als Pac-Man Victim (uncredited) |
 | Joshua Holmes als Arcader (uncredited) |
 | Jean Christophe Loustau als SWAT Team Member (uncredited) |
| Dave Reachill als Lab Technician (uncredited) |
| Tyler Malazo als Choir Kid (uncredited) |
| Chris Columbus | Director |
| Tim Herlihy | Screenplay |
| Timothy Dowling | Screenplay |
| Patrick Jean | Story |
| Johnny Alves | Executive Producer |
| Barry Bernardi | Executive Producer |
| Matias Boucard | Executive Producer |
| Chris Columbus | Producer |
| Allen Covert | Producer |
| Benjamin Darras | Executive Producer |
| Jack Giarraputo | Executive Producer |
| Seth Gordon | Executive Producer |
| Kevin Grady | Co-Producer |
| Patrick Jean | Executive Producer |
| Steve Koren | Executive Producer |
| Heather Parry | Executive Producer |
| Mark Radcliffe | Producer |
| Adam Sandler | Producer |
| Ben Waisbren | Executive Producer |
| Amir Mokri | Director of Photography |
| Hughes Winborne | Editor |
| Liz Bernard | Animation |
| Anna Cardillo | Animation |
| Jocelyn Cofer | Animation |
| Brian Franklin | Animation |
| Atsuo Fujiwara | Animation |
| Emilie Goulet | Animation |
| Ellen Hoffmann | Animation |
| David Humphreys | Animation |
| Julius Kwan | Animation |
| Pericles Michielin | Animation |
| Richard Smith | Animation |
| Nicholas St. Clair | Animation |
| Steve Nichols | Animation Supervisor |
| Julien Lasbleiz | VFX Artist |
| Paul Robertson | Animation |
| Steve Boeddeker | Sound Designer |
| Gary Summers | Sound Re-Recording Mixer |
| Rick James | Camera Trainee |
| Peter Wenham | Production Design |
| Ramsey Avery | Supervising Art Director |
| Stephen Christensen | Art Direction |
| Luke Freeborn | Art Direction |
| Peter Grundy | Art Direction |
| Richard L. Johnson | Supervising Art Director |
| Rosemary Brandenburg | Set Decoration |
| Rosalie Board | Set Decoration |
| Jo-Ann MacNeil | Makeup Department Head |
| Ann Pala | Makeup Department Head |
| Leslie A. Sebert | Makeup Artist |
| Chris Bretecher | Set Designer |
| Aric Cheng | Set Designer |
| William Cheng | Set Designer |
| Karl Crosby | Set Designer |
| Alexandra Hooper | Set Decoration Buyer |
| Svjetlana Jaklenec | Set Dresser |
| Jane Janigan | Set Dresser |
| Noelle King | Set Designer |
| Patricia Larman | Set Decoration Buyer |
| Brenda McClennin | Set Decoration Buyer |
| Byron Patchett | Set Dresser |
| Natasha Peschlow | Assistant Art Director |
| Andrew Redekop | Assistant Art Director |
| Jennifer Wood | Set Decoration Buyer |
| Luke Dunn Gielmuda | Sound Effects Editor |
| Adam Kopald | Sound Effects Editor |
| Steve Slanec | Supervising Sound Editor |
| Steve Slanec | ADR Editor |
| Nancy Au | Costume Supervisor |
| Erin Daprato | Set Costumer |
| Sheila E. Pruden | Costume Supervisor |
| Anthony Zwartouw | VFX Artist |
| Andrew M. Young | Visual Effects Supervisor |
| Edson Williams | Visual Effects |
| Lily Shapiro | Visual Effects Producer |
| Eric Schoellnast | VFX Artist |
| Elizabeth Schafer Knovick | Visual Effects Producer |
| Pinto Sasikumar | Visual Effects Producer |
| Eddy Richard | Visual Effects Supervisor |
| Thomas Reppen | Visual Effects Producer |
| Gunnar Radeloff | VFX Artist |
| Rémi Pierre | VFX Artist |
| Jesse Morrow | VFX Artist |
| Stephanie Molk | VFX Artist |
| Mark Alan Loso | VFX Artist |
| Max Leonard | Visual Effects Producer |
| Dave Levine | Visual Effects |
| Don Lee | Visual Effects Supervisor |
| Mårten Larsson | Visual Effects Supervisor |
| Tarun Kripalani | Visual Effects Producer |
| Daniel Kramer | Visual Effects Supervisor |
| Beau Janzen | VFX Artist |
| Lina Hum | VFX Artist |
| Christian Hejnal | Visual Effects Producer |
| Pawel Grochola | VFX Artist |
| Bryan Godwin | Visual Effects Supervisor |
| Reggie Fourmyle | VFX Artist |
| Komal Dogra | VFX Artist |
| Emilien Dessons | Visual Effects Supervisor |
| Denise Davis | Visual Effects Producer |
| Alessandro Cioffi | Visual Effects Supervisor |
| Matthew E. Butler | Visual Effects Supervisor |
| Pierre Bonnette | VFX Artist |
| Austin Baerg | VFX Artist |
| Sean Bourdeau | Grip |
| Andrew Caney | Grip |
| Michael Galbraith | Gaffer |
| Alicia Turner | Stunts |
| Alicia Turner | Stunt Double |
| Larissa Stadnichuk | Stunts |
| Ana Shepherd | Stunts |
| Mariko Saito | Stunts |
| Mariko Saito | Stunt Double |
| Jennifer Murray | Stunts |
| Irma Leong | Stunts |
| Zandara Kennedy | Stunts |
| Zandara Kennedy | Stunt Double |
| Stephanie Fonceca | Stunts |
| Christine Ebadi | Stunts |
| Bernadette Couture | Stunts |
| Shelley Cook | Stunts |
| Sharon Canovas | Stunts |
| Krista Bell | Stunts |
| Sally Bishop | Stunts |
| Marie-Ève Beckers | Utility Stunts |
| Bob Brown | Stunt Coordinator |
| Layton Morrison | Stunt Coordinator |
| Jon H. Epstein | Stunt Coordinator |
| Bob Brown | Second Unit Director |
| Chris Cenatiempo | Stunts |
| Jimmy N. Roberts | Stunt Driver |
| K.C. Hodenfield | First Assistant Director |
| Owen Walstrom | Stunt Driver |
| Clay Cullen | Stunt Driver |
| Aaron Vexler | Stunts |
| Lauro Chartrand | Stunts |
| Dana Howes | Transportation Coordinator |
| Arlene Halpenny-Heeley | Picture Car Coordinator |
| Angela Demo | Casting |
| Barbara J. McCarthy | Casting |
| Christine Wada | Costume Designer |
| Henry Jackman | Original Music Composer |
| La Peikang | Executive Producer |
| Michael Barnathan | Executive Producer |
| Tim Herlihy | Screenstory |
| George Hull | Conceptual Design |
