 | Jessica Biel als Rose Johnny |
 | Eddie Redmayne als Qwerty Doolittle |
 | Forest Whitaker als Charlie |
 | Ray Liotta als Jack Doheny |
 | Patrick Swayze als Velvet Larry |
 | Lisa Kudrow als Sally |
 | Kris Kristofferson als Randall |
 | Sanaa Lathan als Diana |
 | Ravi Patel als Sanjay |
 | Mandy June Turpin als Nurse Jenkins |
 | Diana Prince als Stripper (uncredited) |
 | Chandler Canterbury als Billy |
 | Navid Negahban als Doctor Brooks |
 | Billy Wirth als David |
 | Don Swayze als Bouncher |
 | Ben Hernandez Bray als Security |
 | Joe Holt als Resident Doctor |
 | L. Scott Caldwell als Nurse Gomez |
 | Riki Lindhome als Nicole |
 | Ana Berry als Female Host |
 | Soledad Campos als Catholic Nun |
| Danvy Pham als Velvet Larry's Girl |
 | Sala Baker als Thug #1 |
| Alejandro Romero als Lexus |
| Jeffery A. Baker als Slim |
| Jesse Henecke als Loan Manager |
| Leo Trombetta | Editor |
| Dan Morski | Art Direction |
| Timothy Linh Bui | Director |
| Keith Neely | Production Design |
| Didier Rachou | Original Music Composer |
| Ross M. Dinerstein | Producer |
| Tracee Stanley | Producer |
| Timothy Linh Bui | Producer |
| Jonathan Sela | Director of Photography |
| Bobby Schwartz | Producer |
| Timothy Linh Bui | Writer |
| Stephane Gauger | Story |
| Forest Whitaker | Producer |
| Timothy Linh Bui | Story |
| Sala Baker | Stunt Double |
| Steve M. Davison | Stunt Coordinator |
| Jeffrey J. Dashnaw | Utility Stunts |
| Jimmy N. Roberts | Stunt Double |
| Carrick O'Quinn | Utility Stunts |
| Eileen Weisinger | Stunt Double |
| Kimberly Fox | Executive Producer |
| Ron Hartenbaum | Co-Executive Producer |
| Douglas Kuber | Co-Executive Producer |
| Rick Lashbrook | Executive Producer |
| Shaun Redick | Executive Producer |
| Alison Semenza | Co-Executive Producer |
| Geoff Stults | Co-Executive Producer |
| Ronnie Yeskel | Casting |
| Michelle Levy | Casting |
| Magali Guidasci | Costume Design |
| David A. Koneff | Set Decoration |
| Barbara Augustus | Key Makeup Artist |
| Miia Kovero | Hair Department Head |
| Margarita Pidgeon | Key Hair Stylist |
| Gigi Williams | Makeup Department Head |
| John Hartigan | Special Effects Coordinator |
| Leo Vezzali | Visual Effects Supervisor |
| Barry Berona | Second Unit Director of Photography |
| Scott R. Todd | Gaffer |
| Chuck Zlotnick | Still Photographer |
| Debra Baum | Music Supervisor |
