 | Danny Glover als Lieutenant Mike Harrigan |
 | Gary Busey als Peter Keyes |
 | Rubén Blades als Danny Archuleta |
 | María Conchita Alonso als Leona Cantrell |
 | Bill Paxton als Jerry Lambert |
 | Robert Davi als Captain Phil Heinemann |
 | Adam Baldwin als Garber |
 | Kevin Peter Hall als The Predator |
 | Kent McCord als Captain B. Pilgrim |
 | Morton Downey, Jr. als Tony Pope |
 | Calvin Lockhart als King Willie |
 | Steve Kahan als Sergeant |
 | Henry Kingi als El Scorpio |
 | Corey Rand als Ramon Vega |
 | Elpidia Carrillo als Anna |
 | Lilyan Chauvin als Irene Edwards |
| Michael Mark Edmondson als Gold Tooth |
 | Teri Weigel als Colombian Girl |
| William R. Perry als Subway Gang Leader |
| Alex Chapman als Subway Gang |
| Gus Williams als Subway Gang |
 | John Cann als Subway Gang |
 | Michael Papajohn als Subway Gang |
 | Louis Eppolito als Patrolman |
 | Charles Haugk als Charlie |
 | Sylvia Kauders als Ruth |
 | Charles David Richards als Commuter |
 | Julian Reyes als Juan Beltran |
 | Casey Sander als Federal Team |
 | Pat Skipper als Federal Team |
| Carmine Zozzora als Federal Team |
| Valerie Karasek als Reporter |
| Chuck Boyd als Reporter |
 | David Starwalt als Reporter |
 | Abraham Alvarez als Reporter |
 | Jim Ishida als Reporter |
 | George Christy als Reporter |
 | Lucinda Weist als Reporter |
 | Richard Anthony Crenna als Paramedic |
 | Billy 'Sly' Williams als Paramedic |
 | Paulo Tocha als Detective |
 | Jsu Garcia als Detective |
| DeLynn Binzel als Hooker |
| Tom Finnegan als Officer |
| Patience Moore als Officer |
| Kashka als Jamaican |
| Jeffrey Reed als Jamaican |
| Carl Pistilli als Cop on Phone |
 | Vonte Sweet als Sweet |
| Ronald Moss als Jerome |
 | Brian Levinson als Brian |
| Harri James als Leona's Friend |
| Beth Kanar als Woman Officer |
| Paul Abascal als Cop |
 | Michael Wiseman als Cop |
 | Thomas Rosales Jr. als El Scorpio Gang Member (uncredited) |
| Charles F. FitzSimons als OWLF Task Force Agent (uncredited) |
| John-Michael Steele als Det. Williams (uncredited) |
 | Hal Rayle als The Predator (voice) (uncredited) |
| David B. Levinson als King Kong (uncredited) |
| Eric Mansker als Jamaican Gang Member (uncredited) |
| Vladimir McCrary als Jamaican Gang Member (uncredited) |
 | Manny Perry als King Willie Gang Member (uncredited) |
| Beverly Overstreet als Girl at Fire Hydrant (uncredited) |
| Walter Smith als Train Passenger (uncredited) |
| Ron Stein als Train Passenger (uncredited) |
| Nico Stevens als Train Passenger (uncredited) |
| Wyatt Weed als Boar Predator (uncredited) |
 | Philip Weyland als Man in Crushed Car (uncredited) |
 | Frank Wood als Remote Broadcast Producer (uncredited) |
| Stephen Hopkins | Director |
| Alan Silvestri | Original Music Composer |
| Peter Levy | Director of Photography |
| Suzanne Todd | Associate Producer |
| Lawrence G. Paull | Production Design |
| Mark Goldblatt | Editor |
| Rick Simpson | Set Decoration |
| Joel Silver | Producer |
| Jim Thomas | Characters |
| Jim Thomas | Writer |
| Lawrence Gordon | Producer |
| John Thomas | Characters |
| John Thomas | Writer |
| Jackie Burch | Casting |
| Lloyd Levin | Executive Producer |
| John Davis | Producer |
| Ferne Cassel | Casting |
| Bert Lovitt | Editor |
| Jimmy Ortega | Stunts |
| Dean Beville | Sound Effects Editor |
| Josh McLaglen | First Assistant Director |
| Marilyn Vance | Costume Design |
| Gilbert B. Combs | Stunts |
| Kenny Bates | Stunts |
| Eddie Smith | Stunts |
| Ron Bartlett | Sound Editor |
| Richard F. Mays | Set Designer |
| Tony Brubaker | Stunts |
| David Balcorta | Stunts |
| Phil Chong | Stunts |
| Ron Stein | Stunts |
| Michael Levy | Executive Producer |
| J. Michael Muro | Steadicam Operator |
| Sally Thornton | Set Designer |
| Henry Kingi | Stunts |
| Ken Pepiot | Special Effects Supervisor |
| Daniel J. Lester | Costume Supervisor |
| James B. Campbell | Orchestrator |
| Geoff Hubbard | Art Direction |
| Joel Hynek | Visual Effects Supervisor |
| Tierre Turner | Stunts |
| Thomas Rosales Jr. | Stunts |
| William C. Carruth | ADR Supervisor |
| Alan Oliney | Stunts |
| Dennis Scott | Stunts |
| Gary Davis | Stunt Coordinator |
| Randy Hall | Stunts |
| Ronald Sinclair | ADR Editor |
| George Simpson | Sound Effects Editor |
| Marvin Walowitz | Sound Effects Editor |
| William Stout | Creature Design |
| Chris David | Sound Re-Recording Mixer |
| John Dunn | Sound Effects Editor |
| Ronnie Rondell Jr. | Stunts |
| Eric Mansker | Stunts |
| Brian Simpson | Stunts |
| Jeff Cadiente | Stunts |
| Gene Hartline | Stunts |
| Terry Carr | Co-Producer |
| Robert Grasmere | VFX Supervisor |
| Robert Grasmere | Second Unit Director |
| Lila Finn | Stunts |
| J.W. Kompare | Visual Effects Coordinator |
| Alan D. Purwin | Pilot |
| Lisa Blok-Linson | Location Manager |
| Mello Alexandria | Stunts |
| Pieter Hubbard | Dialogue Editor |
| Perry Barndt | Stunts |
| Paul Abascal | Hairstylist |
| Krishna Rao | Camera Operator |
| Tom Joyner | Unit Production Manager |
| Tom Joyner | Co-Producer |
| Rusty McClennon | Stunts |
| Scott H. Eddo | Makeup Designer |
| Cody Glenn | Stunts |
| Elinor Bardach | Key Costumer |
| Donald Flick | Sound Effects Editor |
| Richard Overton | Sound Re-Recording Mixer |
| Jeanne Van Cott | Production Manager |
| David Lewis Yewdall | Sound Effects Editor |
| Kenneth Karman | Music Editor |
| Richard Foreman Jr. | Still Photographer |
| Gary S. Gerlich | Supervising Dialogue Editor |
| Sergio Reyes | Sound Re-Recording Mixer |
| James M. Halty | Stunts |
| Alan Manzer | Set Designer |
| Jordu Schell | Sculptor |
| Steve Picerni | Stunts |
| Tommy Tomlinson | Property Master |
| Elliott Koretz | Sound Editor |
| William H. Burton Jr. | Stunts |
| George McDowell Agnew | Location Manager |
| B. Tennyson Sebastian III | Sound Re-Recording Mixer |
| Sonny P. Filippini | Script Supervisor |
| Michael Mills | Makeup Supervisor |
| David Bartlett | Sound Effects Editor |
| Chuck Picerni Jr. | Stunts |
| Marian Green | Stunts |
| Pat Romano | Stunts |
| R. David Smith | Stunts |
| Manny Perry | Stunts |
| Gene McLaughlin | Stunts |
| Clarence Lynn Price | Construction Coordinator |
| Eddie L. Watkins | Stunts |
| Bruce Richter | Carpenter |
| Stuart Abramson | Key Grip |
| Neil Garland | Propmaker |
| Hal Sanders | Dialogue Editor |
| Bruce Lacey | ADR Editor |
| Clete Cetrone | Propmaker |
| Dane Farwell | Stunts |
| Hank Mayo | Conceptual Design |
| Foster K. Denker | Gaffer |
| David Burton | Stunts |
| Rick Kahana | Stunts |
| J. Tom Archuleta | Second Assistant Director |
| Richard Raguse | Sound Mixer |
| Alex Algarin | Sound Re-Recording Mixer |
| Karen Penhale | Production Coordinator |
| J.P. Romano | Stunts |
| Mike Ceballos | Stunts |
| Don Sheldon | Hairstylist |
| Kevin Westmore | Makeup Artist |
| Louis M. Mann | Set Designer |
| Luigi Mugavero | Set Dresser |
| Judee Flick | Sound Effects Editor |
| Bill Hargrave | Boom Operator |
| Jenna Abrahamson-Minardi | Lighting Technician |
| Laurence Flynn | Best Boy Electric |
| Curtis Foster | Best Boy Electric |
| Laura Krumholz | First Assistant Editor |
| Janet Brady | Stunts |
| Bruce Gattenbein | Stunts |
| Gregg Dandridge | Stunts |
| Cliff McLaughlin | Stunts |
| Philip Weyland | Stunts |
| Dana Mackey | Stunts |
| Edward D. Markley | Production Manager |
| Christopher T. Gerrity | Second Second Assistant Director |
| Bob K. Cummings | Stunts |
| Lionel Douglass | Stunts |
| Danny Rogers | Stunts |
| Mike De Luna | Stunts |
| Joy Hooper | Stunts |
| Jon Curtis Price | Special Effects |
| Claude Jay McLin | Stunts |
