 | Johnny Depp als John Dillinger |
 | Christian Bale als Melvin Purvis |
 | Marion Cotillard als Billie Frechette |
 | Jason Clarke als John 'Red' Hamilton |
 | Rory Cochrane als Agent Carter Baum |
 | Billy Crudup als J. Edgar Hoover |
 | Stephen Dorff als Homer Van Meter |
 | Stephen Lang als Charles Winstead |
 | John Ortiz als Phil D'Andrea |
 | Giovanni Ribisi als Alvin Karpis |
 | David Wenham als Harry 'Pete' Pierpont |
 | John Michael Bolger als Martin Zarkovich |
 | Bill Camp als Frank Nitti |
 | Matt Craven als Gerry Campbell |
 | Don Frye als Clarence Hurt |
 | Spencer Garrett als Tommy Carroll |
 | Peter Gerety als Louis Piquett |
 | Shawn Hatosy als Agent John Madala |
 | Stephen Graham als 'Baby Face Nelson' |
 | John Hoogenakker als Agent Hugh Clegg |
 | Branka Katić als Anna Sage |
 | Domenick Lombardozzi als Gilbert Catena |
 | Emilie de Ravin als Anna Patzke |
 | Leelee Sobieski als Polly Hamilton |
 | David Warshofsky als Warden Baker |
 | Rebecca Spence als Doris Rogers |
 | Michael Bentt als Herbert Youngblood |
 | Channing Tatum als 'Pretty Boy Floyd' |
 | Carey Mulligan als Carol Slayman |
 | Christian Stolte als Charles Makley |
 | Adam Mucci als Agent Harold Reinecke |
 | John Judd als Turnkey |
 | James Russo als Walter Dietrich |
| Michael Vieau als Ed Shouse |
| John Kishline als Guard Dainard |
| Wesley Walker als Jim Leslie |
 | John Scherp als Earl Adams |
| Elena Kenney als Viola Norris |
| William Nero Jr. als Toddler on Farm |
| Michael Sassone als Farmer |
| Madison Dirks als Agent Warren Barton |
 | Casey Siemaszko als Harry Berman |
 | Peter DeFaria als Grover Weyland |
| Jonathan Macchi als Tellers |
| Jeff Shannon als Angry Cop |
 | Robyn LeAnn Scott als Ella Natasky |
 | Richard Short als Agent Sam Cowley |
 | Randy Ryan als Agent Julius Rice |
 | Kurt Naebig als Agent William Rorer |
 | Diana Krall als Torch Singer |
 | Shanyn Leigh als Helen Gillis |
 | Chandler Williams als Clyde Tolson |
 | Lili Taylor als Sheriff Lillian Holley |
| Stephen Spencer als Emil Wanatka |
 | Rick Uecker als Edward Saager |
| Joel Thingvall als FBI Agent (uncredited) |
 | Jordan Lawson als Prisoner (uncredited) |
 | Angelina Lyubomirova als Coat Check Girl (uncredited) |
| Bryan Burrough | Novel |
| Ronan Bennett | Screenplay |
| G. Mac Brown | Executive Producer |
| Nathan Crowley | Production Design |
| Rosemary Brandenburg | Set Decoration |
| Michael Mann | Director |
| Michael Mann | Screenplay |
| Robert De Niro | Executive Producer |
| Kevin Misher | Producer |
| Jane Rosenthal | Executive Producer |
| Ann Biderman | Screenplay |
| Colleen Atwood | Costume Design |
| Michael Mann | Producer |
| Avy Kaufman | Casting |
| Bonnie Timmermann | Casting |
| William Ladd Skinner | Art Direction |
| Jeffrey Ford | Editor |
| Elliot Goldenthal | Original Music Composer |
| Paul Rubell | Editor |
| Jane Galli | Makeup Department Head |
| Christine L. Cantella | Assistant Costume Designer |
| Chris Cuevas | First Assistant Camera |
| Tom Lalley | Sound Re-Recording Mixer |
| Amber Jordyn | Set Costumer |
| Amanda McLaughlin | Set Costumer |
| Terry Atchison | Armorer |
| John Grillo | Camera Operator |
| Roberto De Angelis | Steadicam Operator |
| Robert Stadd | Visual Effects Supervisor |
| John Roesch | Foley |
| Sandy Berman | Sound Effects Editor |
| James Morioka | Sound Effects Editor |
| Brian Scott Olds | First Assistant Editor |
| Drew Rosas | Art Department Coordinator |
| Cheryl Beasley Blackwell | Costume Supervisor |
| Bill Taylor | Visual Effects Supervisor |
| Laura Kaminski | Set Costumer |
| Howard Fannon | Armorer |
| Peter Mountain | Still Photographer |
| Fatima Robinson | Choreographer |
| James W. Apted | First Assistant Camera |
| Jeremy Bradley | Visual Effects Editor |
| Jeremy Peirson | Supervising Sound Editor |
| Agnes M. Gibicar | Key Hair Stylist |
| Lois J. Drabkin | Casting Associate |
| Jeannie Vanko | Set Costumer |
| Łukasz Bielan | Camera Operator |
| Dick Edwards | Visual Effects Supervisor |
| Mike Chiado | Digital Intermediate |
| Don Parsons | Special Effects Coordinator |
| Bob E. Krattiger | Gaffer |
| Bruce Tanis | Sound Effects Editor |
| Leslie Webb | First Assistant Editor |
| Jackson Yu | First Assistant Editor |
| Michael Diersing | Construction Coordinator |
| Dante Spinotti | Director of Photography |
| Rebekah Burgess | Researcher |
| John Joseph Thomas | Sound Effects Editor |
| Karen McDonald | Makeup Artist |
| Bob Kretschmer | Wigmaker |
| Mark Blecha | Script Coordinator |
| Brandon Walston | Researcher |
| Catherine Sudolcan | Visual Effects Producer |
| Syd Dutton | Visual Effects Supervisor |
| Daniel Chuba | Visual Effects Producer |
| Alyson Dee Moore | Foley |
| Bryan O. Watkins | Sound Effects Editor |
| Patty York | Makeup Artist |
| Jenne Lee | Art Department Coordinator |
| Bruno Van Zeebroeck | Special Effects Supervisor |
| Bill Guiette | Armorer |
| Alicia Accardo | Script Supervisor |
| Robert Krzeminski | Rigging Grip |
| Ken Blackwell | Visual Effects Editor |
| Emanuel Millar | Hair Department Head |
| Conor Dooley | Casting Associate |
| Jennifer Jobst | Costume Supervisor |
| John P. Friday | Rigging Gaffer |
| Leeba Zakharov | Casting Associate |
| Dominic Napolitano | First Assistant Camera |
| Claire Hedlund | Set Costumer |
| Kim Lee | Visual Effects Producer |
| Laurent Kossayan | Supervising Sound Editor |
| Jay Cheng | Set Costumer |
| Donna O'Neal | Set Costumer |
| Charles Jimenez | Rigging Grip |
| Lauren Ritchie | Visual Effects Producer |
| Nick Monton | Digital Intermediate |
| Steven Rosenblum | Additional Editing |
| Patrick Lumb | Supervising Art Director |
| Nancy McCrumb | Stunts |
| Harry Lu | Armorer |
| Russell Farmarco | ADR Editor |
| Cameron Steenhagen | ADR Editor |
| Thomas Jones | Dialogue Editor |
| Russell Farmarco | Dialogue Editor |
| Thomas Jones | ADR Editor |
| Cameron Steenhagen | Dialogue Editor |
| David Bach | Dialogue Editor |
| Kris Peck | Property Master |
| Will Ralston | ADR Editor |
| Mike Hopkins | Dialogue Editor |
| Gary Jay | Second Unit Director of Photography |
| David Bach | ADR Editor |
| Mike Hopkins | ADR Editor |
| Will Ralston | Dialogue Editor |
| Hugh Waddell | ADR Supervisor |
| Matthias Gohl | Music Producer |
| Matthias Gohl | Orchestrator |
| Vicki L. Fischer | Makeup Artist |
| James Logan | Stunts |
| Chuck Adamson | In Memory Of |
| Darren Wiczek | Stunt Driver |
| Tracey Ruggiero | Stunts |
| Suzanne Prescott | Stunts |
| Darrin Prescott | Stunt Coordinator |
| James Palmer | Stunts |
| Dailyn Matthews | Stunts |
| Tom Lowell | Stunts |
| Rick LeFevour | Stunts |
| Theo Kypri | Stunt Double |
| Jason Lee Huett | Stunts |
| Jimmy Hart | Stunts |
| Jeremy Fry | Stunts |
| Brian Duffy | Stunts |
| Max Daniels | Stunts |
| Jennifer Badger | Stunts |
| Hank Amos | Stunts |
| Wade Allen | Stunts |
| David John Adamson | Stunts |
| Allen Kupetsky | Second Assistant Director |
| Maria Norman | Associate Producer |
| Linda Perlin | Utility Stunts |
| Natalie M. Meyer | Utility Stunts |
