 | Dania Ramírez als Sadie |
 | Jennifer Carpenter als Angela Vidal |
 | Jay Hernandez als Jake |
 | Steve Harris als Scott Percival |
 | Greg Germann als Lawrence |
 | Johnathon Schaech als George Fletcher |
 | Columbus Short als Danny Wilensky |
 | Andrew Fiscella als James McCreedy |
 | Rade Šerbedžija als Yuri Ivanov |
 | Bernard White als Bernard |
 | Elaine Kagan als Wanda Marimon |
 | Marin Hinkle als Kathy |
 | Joey King als Briana |
 | Jermaine Jackson als Nadif |
 | Sharon Ferguson als Jwahir |
 | Denis O'Hare als Randy |
 | Stacy Chbosky als Elise Jackson |
 | Jeannie Epper als Ms. Espinoza |
 | Barry Sigismondi als Bob Orton |
 | Rosine 'Ace' Hatem als Wounded Woman |
 | Christian Svensson als Armed Guard |
 | Scott Donovan als Armed Guard |
 | Michael Potter als Chief of Police |
| Jane Park Smith als News Reporter |
 | Craig Susser als Hazmat Doctor |
| Bert Jernigan als Hazmat Guard |
 | Doug Jones als Thin Infected Man |
 | John C. Meier als Rappelling Guard |
 | Troy Gilbert als Rappelling Guard |
 | Shawn Driscoll als Firefighter |
 | Bryan Ross als Firefighter |
| Robert Hall als Puppeteer |
 | Benjamin Stockham als Infected Child |
 | Michael Hyland als Video Guy |
| Josh Polizzi als National Guard |
 | Ben Messmer als Griffin |
 | Joe Fria als Anonymous Source (uncredited) |
| John Erick Dowdle | Director |
| John Erick Dowdle | Writer |
| Drew Dowdle | Writer |
| Doug Davison | Producer |
| Roy Lee | Producer |
| Lindsey Hayes Kroeger | Casting |
| David Rapaport | Casting |
| Maya Lieberman | Costume Design |
| Douglas Noe | Makeup Department Head |
| Ken Seng | Director of Photography |
| Jon Gary Steele | Production Design |
| Chris Cornwell | Art Direction |
| Dena Roth | Set Decoration |
| Jonathan Gording | Contact Lens Technician |
| Larry Waggoner | Hair Department Head |
| Solina Tabrizi | Hairstylist |
| Sandi Rowden | Key Makeup Artist |
| Toby Lamm | Makeup Artist |
| Gabriel De Cunto | Makeup Effects |
| Robert Hall | Makeup Effects Designer |
| Cristina B. Avery | Art Department Assistant |
| Brett McKenzie | Art Department Coordinator |
| David Elliott | Construction Coordinator |
| Sharleen Bright | Paint Coordinator |
| Max E. Brehme | Property Master |
| Barbara Mesney | Set Designer |
| James E. Tocci | Set Designer |
| Andy C. Huber | Assistant Chief Lighting Technician |
| Joseph Aguirre | Camera Operator |
| Michael LaViolette | Chief Lighting Technician |
| Dave Wightman | First Assistant Camera |
| Craig Bilodeau | Key Grip |
| Bill-Brady Majors | Key Grip |
| Kara Rittenhouse | Second Assistant Camera |
| Annie Wildmoser | Second Assistant Camera |
| John Bramley | Still Photographer |
| David Weisberg | ADR Mixer |
| Erin Oakley | ADR Supervisor |
| Scott Heflin | Boom Operator |
| Scott G.G. Haller | Dialogue Editor |
| Jacob Riehle | First Assistant Sound Editor |
| Robin Harlan | Foley Artist |
| Sarah Monat | Foley Artist |
| Randy Singer | Foley Mixer |
| Sean McCormack | Foley Supervisor |
| Paul Pirola | Sound Designer |
| Tim Tuchrello | Sound Editor |
| Kami Asgar | Supervising Sound Editor |
| John Marquis | Supervising Sound Editor |
| Jeffrey J. Haboush | Supervising Sound Editor |
| Greg P. Russell | Supervising Sound Editor |
| John Hartigan | Special Effects Coordinator |
| Ryan Reeb | CG Artist |
| Steven J. Meyer | Compositing Supervisor |
| Greg Groenekamp | Compositor |
| Bethany Pederson Onstad | Compositor |
| Deke Kincaid | Compositor |
| Diana Hinek | Compositor |
| Nathan Overstrom | Compositor |
| Zachariah Zaubi | Compositor |
| James Mark Dunn | Concept Artist |
| Raoul Bolognini | Visual Effects Producer |
| Rocco Passionino | Visual Effects Supervisor |
| Lance Gilbert | Stunt Coordinator |
| Julie Swistak | Casting Associate |
| Heidi Higginbotham | Costume Supervisor |
| Laura E. Little | Costume Supervisor |
| Terri Middleton | Costumer |
| Damien Quinn | Costumer |
| Cesha Ventre | Costumer |
| Michael Underwood | Digital Colorist |
| Devin C. Lussier | First Assistant Editor |
| Douglas Dresser | Location Manager |
| Dan Brizendine | Transportation Captain |
| Jayson Ehlers | Transportation Co-Captain |
| Anna Belaro-Rodriguez | Assistant Accountant |
| Charlie Scott | Craft Service |
| Terri Greening | Production Accountant |
| Randin Brown | Production Assistant |
| Matthew Cuny | Production Assistant |
| Mackenzie Horras | Production Assistant |
| Drequinn Johnson | Production Assistant |
| Craig Langus | Production Assistant |
| Jennifer Blair | Production Coordinator |
| Derek Wade | Production Secretary |
| Patricia A. Fullerton | Script Supervisor |
| Kym Langlie | Unit Publicist |
| Elliot Greenberg | Editor |
| Jaume Balagueró | Writer |
| Luiso Berdejo | Writer |
| Paco Plaza | Writer |
| Tim Gilbert | Stunts |
| Troy Gilbert | Stunts |
| Hank Amos | Stunts |
| Randy James Beckman | Stunts |
| Steve Berens | Stunts |
| Dartenea Bryant | Stunts |
| Jake Lombard | Stunts |
| Todd Harris | Storyboard Artist |
