 | Johnny Depp als Rango / Lars (voice) |
 | Isla Fisher als Beans (voice) |
 | Ned Beatty als Mayor (voice) |
 | Bill Nighy als Rattlesnake Jake (voice) |
 | Abigail Breslin als Priscilla (voice) |
 | Alfred Molina als Roadkill (voice) |
 | Stephen Root als Doc / Merrimack / Mr. Snuggles (voice) |
 | Harry Dean Stanton als Balthazar (voice) |
 | Timothy Olyphant als Spirit of the West (voice) |
 | Ray Winstone als Bad Bill (voice) |
 | Ian Abercrombie als Ambrose (voice) |
 | Gil Birmingham als Wounded Bird (voice) |
 | James Ward Byrkit als Waffles / Gordy / Papa Joad / Cousin Murt / Curlie / Knife Attacker / Rodent Kid (voice) |
 | Claudia Black als Angelique (voice) |
 | Blake Clark als Buford (voice) |
 | John Cothran als Elgin (voice) |
 | Patrika Darbo als Delilah / Maybelle (voice) |
 | George DelHoyo als Señor Flan - Mariachi Accordion (voice) |
 | Maile Flanagan als Lucky (voice) |
 | Charles Fleischer als Elbows (voice) |
 | Beth Grant als Bonnie (voice) |
 | Ryan Hurst als Jedidiah (voice) |
 | Vincent Kartheiser als Ezekiel / Lasso Rodent (voice) |
 | Hemky Madera als Chorizo (voice) |
 | Alex Manugian als Spoons (voice) |
 | Mark 'Crash' McCreery als Parsons (voice) |
 | Joe Nuñez als Rock-Eye (voice) |
 | Christopher Lee Parson als Hazel / Kinski / Stump / Clinker / Lenny / Boseefus (voice) |
 | Lew Temple als Furgus / Hitch (voice) |
 | Alanna Ubach als Boo / Cletus / Fresca / Miss Daisy (voice) |
 | Gore Verbinski als Sgt Turley / Crevice / Slim / Lupe - Mariachi Violin (voice) |
 | Kym Whitley als Melonee (voice) |
 | Keith Campbell als Sod Buster (voice) |
| Gore Verbinski | Director |
| John Logan | Writer |
| John Logan | Story |
| Gore Verbinski | Story |
| James Ward Byrkit | Story |
| Chuck Duke | Animation |
| Travis Tohill | Animation |
| John B. Carls | Producer |
| Graham King | Producer |
| Gore Verbinski | Producer |
| Denise Chamian | Casting |
| Kevin Kaska | Orchestrator |
| James Ward Byrkit | Storyboard Artist |
| Mike Marcuzzi | Creature Technical Director |
| Hans Zimmer | Original Music Composer |
| Ruth Lambert | Additional Casting |
| Robert McGee | Additional Casting |
| Craig Wood | Editor |
| Mark Bakshi | Consulting Producer |
| Adam Cramer | Co-Producer |
| Shari Hanson | Co-Producer |
| Tim Headington | Executive Producer |
| Nils Peyron | Consulting Producer |
| David Shannon | Co-Producer |
| David Shannon | Concept Artist |
| Mark 'Crash' McCreery | Production Design |
| John Bell | Supervising Art Director |
| Christine Altomari | Production Supervisor |
| Gary Kout | Production Supervisor |
| Carol Norton | Production Manager |
| Adam Somner | Production Manager |
| Richard Stirling | Post Production Supervisor |
| Jenna Grigg Thomas | Production Manager |
| Ian Calip | Second Assistant Director |
| Adam Somner | First Assistant Director |
| James Carson | Concept Artist |
| Eunha Choi | Title Designer |
| Tom De Rosier | Storyboard Artist |
| Michael Diersing | Construction Coordinator |
| David Feiss | Story Artist |
| Bradley Good | Assistant Property Master |
| Delia Gosman | Storyboard Artist |
| Jurgen Gross | Storyboard Artist |
| Anthony Leonardi III | Storyboard Artist |
| Jim Martin | Production Illustrator |
| Kris Peck | Property Master |
| Eric Ramirez | Set Dresser |
| Keith Campbell | Stunt Coordinator |
| Ffilip Bolton | Lighting Technician |
| Alejandro J. Castillo | Lighting Technician |
| Greg Etheredge | Electrician |
| Peter Geraghty | First Assistant "B" Camera |
| James Goldman | Assistant Camera |
| Samuel R. Harrison III | Video Assist Operator |
| Patrick Hoeschen | Gaffer |
| John D. Miller | Best Boy Grip |
| Juan Morse | Lighting Technician |
| Martin Schaer | Camera Operator |
| Steven Serna | Grip |
| Krysti Baxter | Casting Assistant |
| Angela Demo | Casting Associate |
| Holly Dorff | ADR Voice Casting |
| Marina Marit | Set Costumer |
| Tom Barrett | Additional Editor |
| Dan Goslee | Digital Intermediate Assistant |
| David Michael Green | Post Production Technical Engineer |
| Joel Griffen | Assistant Editor |
| Derrek Horn | Post Production Assistant |
| Wyatt Jones | Additional Editor |
| Simon Morgan | First Assistant Editor |
| Jim Passon | Color Timer |
| Alex Romano | Digital Intermediate Editor |
| Stefan Sonnenfeld | Colorist |
| Michael Sean Ryan | Transportation Coordinator |
| Ben Rosenblatt | Executive In Charge Of Post Production |
| Elizabeth Galloway | Assistant Production Coordinator |
| Rick Garcia | Thanks |
| Robert Lamkin | Catering |
| JoAnn Fregalette Jansen | Choreographer |
| Jessica Drake | Dialect Coach |
| Sam Chwat | Dialect Coach |
| Henry Hobson | Title Designer |
| David Hickey | Payroll Accountant |
| Patrick R. Siembieda | Production Accountant |
| Brenda T. Huey | Production Accountant |
| A.K. Hottman | Production Assistant |
| Brandon Loomis | Production Assistant |
| Devin Toft | Production Assistant |
| John Bartnicki | Production Assistant |
| Richard Itskovich | Production Assistant |
| Tien Nguyen | Production Assistant |
| Chrysta Marie Burton | Production Coordinator |
| Laura Caulfield | Legal Services |
| Dan Urrutia | Production Secretary |
| B.J. Smith | Set Medic |
| Lindsey Jayne Boyd | Set Production Assistant |
| Bryant Powell | Stand In |
| Kevin Collins | Stand In |
| Chuck Choi | Score Engineer |
| Sebastián Zuleta | Score Engineer |
| Phill Boucher | Score Engineer |
| Rick Giovinazzo | Orchestrator |
| Walt Fowler | Orchestrator |
| Ryeland Allison | Musician |
| Satnam Ramgotra | Musician |
| James Thatcher | Musician |
| Davey Johnstone | Musician |
| David Hidalgo | Musician |
| George Doering | Musician |
| Peter G. Adams | Musician |
| Bryce Jacobs | Musician |
| Craig Eastman | Musician |
| Michael Hobe | Musician |
| Arturo Sandoval | Musician |
| Brian Swartz | Musician |
| Tina Guo | Musician |
| Heitor Pereira | Musician |
| Adam Peters | Additional Music |
| Dominic Lewis | Additional Music |
| John Sponsler | Additional Music |
| Lorne Balfe | Additional Music |
| Tom Gire | Additional Music |
| Heitor Pereira | Additional Music |
| Geoff Zanelli | Additional Music |
| Nick Glennie-Smith | Conductor |
| William V. Malpede | Music Arranger |
| Peter Oso Snell | Music Editor |
| Brett Pierce | Temp Music Editor |
| Daniel Kresco | Score Engineer |
| Doc Kane | ADR Mixer |
| Robert Edwards | ADR Mixer |
| Beauxregard Neylon | ADR Mixer |
| Philip Young | ADR Recordist |
| Coya Elliott | Assistant Dialogue Editor |
| Chris Barron | Assistant Sound Editor |
| Chris Barron | Foley Recordist |
| Brian Robinson | Boom Operator |
| Jeffrey A. Humphreys | Boom Operator |
| Dennie Thorpe | Foley Artist |
| Jana Vance | Foley Artist |
| Dee Selby | Foley Editor |
| Frank Rinella | Foley Mixer |
| Steve Slanec | Foley Supervisor |
| Clint Smith | Sound Recordist |
| Christopher Boyes | Sound Re-Recording Mixer |
| Paul Massey | Sound Re-Recording Mixer |
| Adam Kopald | Sound Editor |
| J.R. Grubbs | Sound Effects Editor |
| Shannon Mills | Sound Effects Editor |
| David C. Hughes | Sound Effects Editor |
| Lee Orloff | Sound Mixer |
| Mike Anderson | Utility Sound |
| Michael Silvers | Supervising Dialogue Editor |
| Addison Teague | Supervising Sound Editor |
| Flannery Huntley | Animation Coordinator |
| Hal Hickel | Animation Director |
| Erik Morgansen | Animation |
| Greg Towner | Animation |
| Joe Ceballos | Matte Painter |
| Tu Le | CG Artist |
| Kevin Sprout | CG Supervisor |
| Leandro Estebecorena | CG Supervisor |
| Christian Alzmann | Concept Artist |
| John Giang | Concept Artist |
| Melaina Mace | Concept Artist |
| Devon Cutler | Concept Artist |
| Devon Cutler | Storyboard Artist |
| Adrian Watkins | Creature Technical Director |
| Alexandra Weir | Creature Technical Director |
| Chin Kok Tan | Creature Technical Director |
| Frederick Fowles | Creature Technical Director |
| Karen Halliwell | Creature Technical Director |
| Kelvin Chu | Creature Technical Director |
| Maurizio Giglioli | Creature Technical Director |
| Shiv Sundar | Creature Technical Director |
| Goh Kenny | Creature Technical Director |
| Nikita McKinder | Creature Technical Director |
| Chase Cooper | Creature Technical Director |
| Christian Saenz | Creature Technical Director |
| Gary Wu | Creature Technical Director |
| Gem Ronn Cadiz | Creature Technical Director |
| Gregory Weiner | Creature Technical Director |
| Henri Tan | Creature Technical Director |
| Jim Van Allen | Creature Technical Director |
| Jing Cui | Creature Technical Director |
| John Doublestein | Creature Technical Director |
| John Teska | Creature Technical Director |
| John Van Der Zalm | Creature Technical Director |
| Kenneth Bailey | Creature Technical Director |
| Laura Killmaster | Creature Technical Director |
| Quentin Auger | Creature Technical Director |
| Renita Taylor | Creature Technical Director |
| S. Scott Parrish | Creature Technical Director |
| Seung-Hun Lee | Creature Technical Director |
| Sheen Wei Yap | Creature Technical Director |
| Shih Ming Tay | Creature Technical Director |
| Wanghua Huang | Creature Technical Director |
| Attaporn Kanjanasahas | Creature Technical Director |
| Chin Chee Cheah | Matte Painter |
| Juan Pablo Monroy | Matte Painter |
| Michael Bauer | Digital Supervisor |
| Dave Logan | Creature Technical Director |
| Eric J. Dima-ala | Matte Painter |
| Huai Yuan Teh | Modeling |
| Ken Bryan | Modeling |
| Richard Matsushita | Modeling |
| Yap Hon Wui | Modeling |
| Chulev Marko | Modeling |
| Geoff Campbell | Character Modelling Supervisor |
| Jen Howard | Compositing Lead |
| Peter Chesloff | Compositing Lead |
| Tory Mercer | Compositing Lead |
| Nelson Sepulveda | Compositing Supervisor |
| Cristin Pescosolido | Compositor |
| Can Chang | Compositor |
| Jaymie Lam | Compositor |
| Abishek Nair | Digital Compositor |
| Alex Tropiec Jr. | Digital Compositor |
| Ben O'Brien | Digital Compositor |
| Christopher Balog | Digital Compositor |
| Eddy Wong | Digital Compositor |
| Florian Strobl | Digital Compositor |
| Jason Porter | Digital Compositor |
| Justin Kosnikowski | Digital Compositor |
| Marcel Martinez | Digital Compositor |
| Myles Murphy | Digital Compositor |
| Pascale Ville | Digital Compositor |
| Sebastian Feldman | Digital Compositor |
| Tau Gerber | Digital Compositor |
| Tia L. Marshall | Digital Compositor |
| Zameer Hussain | Digital Compositor |
| Janet Lewin | Executive Visual Effects Producer |
| Chad Taylor | Compositing Lead |
| Lam Nguyen | Layout |
| Romaine Coston | Layout |
| Matt Neapolitan | Layout |
| Alex Cannon | Layout |
| Adam Schnitzer | Layout |
| Colin Benoit | Layout Supervisor |
| Nick Walker | Layout Supervisor |
| Melanie Cussac | Production Coordinator |
| Morgan Smith | Production Coordinator |
| David Gottlieb | Sequence Supervisor |
| François Lambert | Sequence Supervisor |
| Jeff Grebe | Sequence Supervisor |
| Jeff Wozniak | Sequence Supervisor |
| Mathieu Boucher | Sequence Supervisor |
| Matt Brumit | Sequence Supervisor |
| Robert Hoffmeister | Sequence Supervisor |
| Scott Younkin | Sequence Supervisor |
| Sean MacKenzie | Sequence Supervisor |
| Steve Braggs | Sequence Supervisor |
| Tom Martinek | Sequence Supervisor |
| André Mazzone | Software Engineer |
| Adam Lee | VFX Artist |
| Bekah Baik | VFX Artist |
| Branko Grujcic | VFX Artist |
| Dong Yeop Shin | VFX Artist |
| Durant Schoon | VFX Artist |
| Erik Shepherd | VFX Artist |
| Indira Guerrieri | VFX Artist |
| Jean-Claude Langer | VFX Artist |
| John Walker | VFX Artist |
| Katharine Evans | VFX Artist |
| Mei Gangwen | VFX Artist |
| Natasha Devaud | VFX Artist |
| Scott Mease | VFX Artist |
| Simeon Bassett | VFX Artist |
| Tracy Nicole Irwin | VFX Artist |
| Bastiaan Koch | Visual Effects |
| Chantell Brown | Visual Effects |
| Emile Edwin Smith | Visual Effects |
| John Kilshaw | Visual Effects |
| Mark 'Crash' McCreery | Visual Effects |
| Michael Gaiser | Visual Effects |
| Shaun Stephenson | Visual Effects |
| Scott Wesley Ross | Visual Effects Assistant Editor |
| Christopher Bannister | Visual Effects Coordinator |
| Cynthia Crimmins | Visual Effects Coordinator |
| Karen Kelly | Visual Effects Coordinator |
| Rachel Galbraith | Visual Effects Coordinator |
| Amy Beresford | Visual Effects Producer |
| Jacqui Lopez | Visual Effects Producer |
| Hayley Nenadal | Visual Effects Production Assistant |
| Jennifer Duncan | Visual Effects Production Assistant |
| Pei'an Lau | Visual Effects Production Assistant |
| Danielle Rubin | Visual Effects Production Manager |
| John Knoll | Visual Effects Supervisor |
| Tim Alexander | Visual Effects Supervisor |
| Dan Bornstein | Visual Effects Technical Director |
| Florian Witzel | Visual Effects Technical Director |
| Alicia Kho | Animation |
| Andre Tong | Animation |
| Barry Lim | Animation |
| Chi Chung Tse | Animation |
| Chun Wing Vincent Yu | Animation |
| Edmund Wong | Animation |
| Frédéric Côté | Animation |
| Geoff Hemphill | Animation |
| Jason Malinowsky | Animation |
| Jay Rennie | Animation |
| Jeff Vacanti | Animation |
| Jess Morris | Animation |
| John Zdankiewicz | Animation |
| Johnny Spinelli | Animation |
| Josh Kent | Animation |
| Kian Shyang Chong | Animation |
| Marc Beaujeau | Animation |
| Maria Goodale | Animation |
| Maureen Seng | Animation |
| Michael Lum | Animation |
| Michael Midlock | Animation |
| Mickael Coedel | Animation |
| Miles Southan | Animation |
| Neil Michka | Animation |
| Roy Tan | Animation |
| Samati Boonchitsitsak | Animation |
| Steve Rawlins | Animation |
| Tan Woei Hong | Animation |
| Tim Waddy | Animation |
| Yee Sang Khet | Animation |
| Zaini Jalani | Animation |
| Zeng Lin | Animation |
| Jackson Yeoh | Animation |
| Alex Cannon | Animation |
| Alexander K. Lee | Animation |
| Atsushi Kojima | Animation |
| Chansoo Kim | Animation |
| Delio Tramontozzi | Animation |
| Jason Ho | Animation |
| Jeremy Cantor | Animation |
| Marco Foglia | Animation |
| Nick Fredin | Animation |
| Shawn Miller | Animation |
| Simon Fillat | Animation |
| Stephen King | Animation |
| Tim Harrington | Animation |
| Bradley Lorimer | Animation |
| J.D. Burditt | Animation |
| Eric Mun Fai Leong | Senior Animator |
| Edward Zhou | Senior Animator |
| Charles Alleneck | Lead Animator |
| Derrick Carlin | Lead Animator |
| Maia Kayser | Lead Animator |
| Shawn Kelly | Lead Animator |
| Andy Wong | Lead Animator |
| Cedric Lo | Lead Animator |
| Eugene Yelchin | Character Designer |
| Joe Murray | Character Designer |
| Alex Cannon | Pre-Visualization Supervisor |
| Hal Hickel | Animation Supervisor |
| Josh Hayes | Story Artist |
| Roger Deakins | Director of Photography |
| Peter Miller | Sound Designer |
| Peter Miller | Supervising Sound Editor |
| Raul Essig | CG Supervisor |
| James Ward Byrkit | Head of Story |
| Jurgen Gross | Story Artist |
| David Gosman | Story Artist |
| David Lowery | Story Artist |
| Tom De Rosier | Story Artist |
| Anthony Leonardi III | Story Artist |
| Scott Wesley Ross | Assistant Editor |
| Patrick Cohen | CG Supervisor |
| Todd Vaziri | Compositing Lead |
| Addison Teague | Sound Designer |
