 | Rachel McAdams als Lisa Reisert |
 | Cillian Murphy als Jackson Rippner |
 | Brian Cox als Joe Reisert |
 | Jayma Mays als Cynthia |
 | Jack Scalia als Charles Keefe |
 | Robert Pine als Bob Taylor |
 | Terry Press als Marianne Taylor |
| Brittany Oaks als Rebecca |
 | Laura Johnson als Blonde Woman |
 | Max Kasch als Headphone Kid |
 | Kyle Gallner als Headphone Kid's Brother |
 | Angela Paton als Nice Lady |
 | Loren Lester als Irate Passenger |
 | Suzie Plakson als Senior Flight Attendant |
 | Monica McSwain als Junior Flight Attendant |
 | Beth Toussaint als Lydia Keefe |
| Adam Gobble als Keefe's Son |
| Megan Crawford als Keefe's Daughter |
 | Carl Gilliard als Taxi Driver |
| Mary Kathleen Gordon als Airline Representative |
 | Philip Pavel als Dallas Ticket Agent |
| Amber Mead als Dallas Ticket Agent |
 | Dey Young als Dallas Gate Agent |
 | Jeanine Jackson als Passenger with Iced Mocha |
 | Carmen Gloria als Airline Passenger (uncredited) |
 | Colby Donaldson als Keefe's Head Bodyguard |
| Chris Bender | Producer |
| Lisa Beach | Casting |
| Sarah Katzman | Casting |
| Bonnie Curtis | Executive Producer |
| Marco Beltrami | Original Music Composer |
| Wes Craven | Director |
| Robert D. Yeoman | Director of Photography |
| Bruce Alan Miller | Production Design |
| Austin Gorg | Assistant Art Director |
| J.C. Spink | Executive Producer |
| Jim Lemley | Executive Producer |
| Stuart Levy | Editor |
| Marianne Maddalena | Producer |
| Patrick Lussier | Editor |
| Andrew Max Cahn | Art Direction |
| Mary Claire Hannan | Costume Design |
| Mason Novick | Executive Producer |
| Carl Ellsworth | Screenplay |
| Carl Ellsworth | Story |
| Chuck Michael | Supervising Sound Editor |
| John Kwiatkowski | Sound Editor |
| Todd Toon | Supervising Sound Editor |
| Charles W. Ritter | Sound Editor |
| David E. Fluhr | Sound Re-Recording Mixer |
| David Kern | Sound Editor |
| Richard Fojo | Assistant Art Director |
| Christina Smith | Makeup Department Head |
| Maggie Martin | Set Decoration |
| Jane English | Makeup Artist |
| Christi K. Work | Costume Supervisor |
| Barbara Lorenz | Hair Department Head |
| Mick Cukurs | Set Designer |
| Jerry Pooler | Visual Effects Supervisor |
| Sheila Waldron | Script Supervisor |
| David A. Arnold | Sound Editor |
| John E. Sullivan | Visual Effects Supervisor |
| David Lingenfelser | Visual Effects Supervisor |
| Tiffany Smith | Visual Effects Producer |
| Adam Kopald | Sound Effects Editor |
| Ron Bolanowski | Special Effects Coordinator |
| Donald Dowd | Floor Runner |
| Hope Slepak | Costume Supervisor |
| June Brickman | Makeup Artist |
| Cynthia Barr | Makeup Artist |
| Susan Carol Schwary | Key Hair Stylist |
| Carol McCoo | Hairstylist |
| Pinky Babajian | Hairstylist |
| Beatriz Kerti | Art Department Coordinator |
| Sara Auhagen | Seamstress |
| Jamelle Flowers | Set Costumer |
| Jalene Murphy | Set Costumer |
| Jonny Winograd | First Assistant Editor |
| Paul 'Eel' Anderson | Set Dresser |
| Keith Sale | Set Dresser |
| Dan Foos | Story |
