 | Dwayne Johnson als John Hartley |
 | Ryan Reynolds als Nolan Booth |
 | Gal Gadot als Sarah Black / The Bishop |
 | Ritu Arya als Inspector Urvashi Das |
 | Chris Diamantopoulos als Sotto Voce |
 | Ivan Mbakop als Tambwe |
 | Vincenzo Amato als Director Gallo |
 | Rafael Petardi als Security Chief Ricci |
 | Seth Michaels als Souvenir Stand Owner |
 | Sebastien Large als Gelato Truck Driver |
 | Guy Nardulli als Museum Reporter / Italian VIP |
 | Andrew Hunter als Moped Tourist |
 | George Tsai als Bali Van Driver |
 | Rawson Marshall Thurber als Exhausted Film Director in Bar |
| Robert Mata als Handsome Bartender |
 | Anthony Belevtsov als Prison Guard Sergeant |
 | Daniel Bernhardt als Drago Grande |
| Yosef Podolski als Lead Guard |
 | Martin Harris als Tower Guard |
 | Alexander Perkins als Intelligence Analyst |
 | Joseph A. Garcia als Old Tech |
| Gonzalo Escudero als Head Waiter |
| Jay Romero als Sotto Vocce Display Room Guard |
 | Ethan Herschenfeld als Aranoub Magdy |
| Brenna Marie Narayan als Cleopatra |
 | Tom Choi als Mongolian Captain |
 | Nick Arapoglou als Officer on Yacht |
 | Robert Clotworthy als Opening Narrator (voice) |
 | Ed Sheeran als Ed Sheeran (uncredited) |
 | Steve Eifert als Prison Captain (uncredited) |
 | Elbert Kim als Italy Vatican Museum Patron (uncredited) |
 | Victoria Paige Watkins als Child (uncredited) |
| Beau Flynn | Producer |
| Hiram Garcia | Producer |
| Dwayne Johnson | Producer |
| Rawson Marshall Thurber | Director |
| Dany Garcia | Producer |
| Wendy Jacobson | Executive Producer |
| Rawson Marshall Thurber | Producer |
| James Bitonti | First Assistant Director |
| Michael L. Sale | Editor |
| Jason Knox-Johnston | Supervising Art Director |
| Jackson Spidell | Fight Choreographer |
| Markus Förderer | Director of Photography |
| Steve Jablonsky | Original Music Composer |
| Andy Nicholson | Production Design |
| Rachel Block | Art Direction |
| Rory Bruen | Supervising Art Director |
| Will Coubrough | Art Direction |
| Andi Crumbley | Art Direction |
| Justin O'Neal Miller | Art Direction |
| Adam Squires | Art Direction |
| Danielle Berman | Set Decoration |
| Larry Dias | Set Decoration |
| David Werntz | Sound Designer |
| Kami Asgar | Supervising Sound Editor |
| Dan Kenyon | Sound Effects Editor |
| Tony Lamberti | Sound Re-Recording Mixer |
| Tony Lamberti | Sound Designer |
| Heather Benson | Makeup Artist |
| Suzanna Boykin | Hairstylist |
| Leay Cangelosi | Hairstylist |
| Jessica Craig | Makeup Artist |
| Nancy Cummings | Makeup Artist |
| Jennifer Hodges | Key Hair Stylist |
| Morgon Lindskog | Makeup Artist |
| Jacqueline Noel | Hairstylist |
| Mark James Ross | Makeup Artist |
| Cassie Russek | Key Hair Stylist |
| Matt Sprunger | Makeup Artist |
| Haile Werntz | Makeup Artist |
| Sam Carter | Set Dresser |
| Ashley Fidalgo Fogleman | Set Designer |
| Terry Hill | Set Dresser |
| Britain Illingworth-Cramer | Set Designer |
| Kristen Jenkins | Set Designer |
| Maxfield Ladish | Set Dresser |
| George Lee | Set Designer |
| Chris McGlamery | Set Dresser |
| Eric Sherlin | Set Dresser |
| Eitan Sonnenberg | Set Dresser |
| Sean McCormack | Supervising Sound Editor |
| Kevin O'Connell | Sound Re-Recording Mixer |
| Blondel Aidoo | Visual Effects Producer |
| Tony Lupoi | Visual Effects Supervisor |
| Rebecca West | Visual Effects Producer |
| Richard Schoen | Costume Supervisor |
| Kate Duke | Set Costumer |
| Stefano De Nardis | Costume Supervisor |
| Ginger Knussmann | Set Costumer |
| Jacinthe Côté | Visual Effects Producer |
| Hubert Maston | Visual Effects Supervisor |
| Sean Pollack | Visual Effects Supervisor |
| Mathieu Raynault | Visual Effects Supervisor |
| Virginie Wintrebert | Visual Effects Producer |
| Tiuana Bell | Costumer |
| Whit Cornwall | Costumer |
| Enrica Iacoboni | Set Costumer |
| Stephanie Powers | Set Costumer |
| Scott Sheldon | Executive Producer |
| Chris Hahn | Stunts |
| Mark LeDoux | VFX Supervisor |
| Chris LeDoux | VFX Supervisor |
| Daniel Dupre | Matte Painter |
| Jon Balcome | CG Supervisor |
| Daniel J. Pastor | Compositing Artist |
| Burke Roane | Animation Supervisor |
| Matt Akey | Visual Effects Producer |
| Steve Dinozzi | Visual Effects Supervisor |
| Bobby Tucker | Visual Effects Producer |
| Jereme Gelske | Visual Effects Coordinator |
| Chad Fetzer | Compositing Lead |
| Brad Lucas | Compositing Artist |
| Butch Seibert | Compositing Artist |
| Christopher Cheng | Compositing Artist |
| Timothy Fescoe | Compositing Artist |
| Ndosi Anyabwile | Compositing Artist |
| Daniel L. Smith | Compositing Artist |
| Daniel Berkowitz | Compositing Artist |
| Scott Curtis | Compositing Artist |
| Daniel Kaczkowski | Compositing Artist |
| Tangela Large | Dialect Coach |
| Nathan Carlson | Graphic Designer |
| John Wildermuth | Co-Producer |
| Mika Saito | Co-Producer |
| Blondel Aidoo | Co-Producer |
| Gabe Hilfer | Music Supervisor |
| Rachel Tenner | Casting |
| Richard R. Hoover | Visual Effects Supervisor |
| Mary E. Vogt | Costume Design |
| Julian Clarke | Editor |
| David B. Householter | Executive Producer |
| Rawson Marshall Thurber | Writer |
| Pedro Eustache | Musician |
| Doug Coleman | Stunt Coordinator |
| Vanessa Zamarripa | Stunts |
| Riley Flanagan | Additional Second Assistant Director |
| Kenneth Koh | VFX Artist |
| Brian Barlettani | Visual Effects Producer |
| Paul E. Short | Stunts |
| Joe Bucaro III | Stunts |
| Tanoai Reed | Stunt Double |
| Peter Epstein | Stunts |
| Dana Howes | Transportation Coordinator |
| Duffy Gaver | Utility Stunts |
| Mickey Giacomazzi | Stunt Driver |
| Nitasha Bhambree | Stunts |
| Hannah Hildebrandt | Art Department Coordinator |
