 | Jerry O'Connell als Clark Kent / Superman / Cyborg Superman (voice) |
 | Rebecca Romijn als Lois Lane (voice) |
 | Rainn Wilson als Lex Luthor (voice) |
 | Cress Williams als John Henry Irons / Steel (voice) |
 | Cameron Monaghan als Connor Kent / Superboy (voice) |
 | Charles Halford als Eradicator / Bibbo Bibbowski (voice) |
 | Patrick Fabian als Hank Henshaw (voice) |
 | Rosario Dawson als Diana Prince / Wonder Woman (voice) |
 | Jason O'Mara als Bruce Wayne / Batman (voice) |
 | Shemar Moore als Victor Stone / Cyborg (voice) |
 | Nathan Fillion als Green Lantern / Hal Jordan (voice) |
 | Christopher Gorham als Barry Allen / The Flash (voice) |
 | Nyambi Nyambi als J'onn J'onzz / John Jones / Martian Manhunter (voice) |
 | Tony Todd als Darkseid (voice) |
 | Jennifer Hale als Martha Kent (voice) |
 | Brenda Strong als Lillian Luthor (voice) |
 | Toks Olagundoye als Cat Grant (voice) |
 | Erica Luttrell als Mercy Graves (voice) |
 | Rocky Carroll als Perry White (voice) |
 | Max Mittelman als Jimmy Olsen (voice) |
 | Paul Eiding als Jonathan Kent (voice) |
 | Trevor Devall als Dabney Donovan (voice) |
| Bob Kane | Characters |
| Jack Kirby | Characters |
| Jerry Siegel | Characters |
| Joe Shuster | Characters |
| Alan Burnett | Co-Producer |
| Sam Liu | Director |
| Sam Liu | Producer |
| Marv Wolfman | Characters |
| Sam Register | Executive Producer |
| James Krieg | Writer |
| Bill Finger | Characters |
| Frederik Wiedmann | Music |
| Christopher D. Lozinski | Editor |
| James Tucker | Executive Producer |
| William Moulton Marston | Characters |
| Louise Simonson | Characters |
| Dan Jurgens | Characters |
| Evan Dockter | Sound Designer |
| Wes Gleason | Casting |
| Tim Sheridan | Writer |
| George Pérez | Characters |
| Roger Stern | Characters |
| Amy McKenna | Producer |
| Jerry Ordway | Characters |
| Joe Certa | Characters |
| Joe Samachson | Characters |
| Matthew Mahoney | Associate Producer |
| Jon Bogdanove | Characters |
