 | Matthew Mercer als Leon Scott Kennedy (voice) |
 | Nicole Tompkins als Jill Valentine (voice) |
 | Kevin Dorman als Chris Redfield (voice) |
 | Stephanie Panisello als Claire Redfield (voice) |
 | Erin Cahill als Rebecca Chambers (voice) |
 | Salli Saffioti als Ingrid Hunnigan (voice) |
 | Daman Mills als Dylan Blake (voice) |
 | Lucien Dodge als JJ (voice) |
 | Cristina Valenzuela als Maria Gomez (voice) |
 | Frank Todaro als Antonio Taylor (voice) |
 | Alejandro Saab als Reporting Student (voice) |
 | Bob Carter als SWAT Captain (voice) |
 | Isaac Robinson-Smith als William (voice) |
 | Bill Butts als Additional Voices (voice) |
 | Brent Mukai als Additional Voices (voice) |
 | Dawn M. Bennett als Additional Voices (voice) |
 | Joe Hernandez als Additional Voices (voice) |
 | John Bentley als Additional Voices (voice) |
 | Kim Gasiciel als Additional Voices (voice) |
 | Luis Bermudez als Additional Voices (voice) |
 | Ryan Colt Levy als Additional Voices (voice) |
 | Tiana Camacho als Additional Voices (voice) |
 | Zeke Alton als Additional Voices (voice) |
| Eiichirō Hasumi | Director |
| Rei Kondo | Original Music Composer |
| Tomohiro Shimizu | CGI Director |
| Makoto Fukami | Screenplay |
| Yun M. Watanabe | Director of Photography |
| Mitsuo Nishio | Editor |
| Derrick Dover | Motion Capture Artist |
| Akihiko Sai | Military Consultant |
| Tadashi Takezaki | Executive Producer |
| Midori Tomita | Executive Producer |
| Haruki Satomi | Executive Producer |
| Takeshi Kikuchi | Executive Producer |
| Kei Miyamoto | Co-Producer |
| Masachika Kawata | Associate Producer |
| Takaki Okamoto | Associate Producer |
| Taki Enomoto | Associate Producer |
| Takahiro Suzuki | Associate Producer |
| Atsushi Furuya | Associate Producer |
| Hiroyasu Shinohara | Producer |
| Jeffrey Rowe | Motion Capture Artist |
| Alexandria Kavy | Motion Capture Artist |
| Joel Dickerson | Motion Capture Artist |
| Keren Louis | Motion Capture Artist |
| Ananda Dawn Jacobs | Motion Capture Artist |
| Masanari Sasaki | Motion Capture Artist |
| Takeyuki Honda | Motion Capture Artist |
| Tsubasa Mukaida | Motion Capture Artist |
| Kai Kitamura | Motion Capture Artist |
| Shunya Sasaki | Motion Capture Artist |
| Ryouko Gomi | Motion Capture Artist |
| Natsumi Sano | Motion Capture Artist |
| Kenta Nitta | Motion Capture Artist |
| Ryuhei Higashiyama | Motion Capture Artist |
| Momotaro Sakae | Motion Capture Artist |
| Takahiro Yoneoka | Motion Capture Artist |
| Runa Kitano | Motion Capture Artist |
| Kei Miyamoto | Other |
| Keisuke Takahashi | Art Direction |
| Yuan Shuo | Art Direction |
| Yuta Morokaji | Action Director |
| Sho Tanaka | Producer |
| Daijo Kudo | Producer |
| Naoto Kase | Producer |
| Koichi Sano | Producer |
| Sachi Sahara | Producer |
| Shuzo Kasahara | Producer |
| Yohei Kikuchi | Producer |
| Mitsuhiko Ikegami | Publicist |
| Shuji Kawasaki | Publicist |
| Ayaka Kamide | Production Manager |
| Yoshitaka Fujimura | Music Editor |
| Shoko Isono | Production Assistant |
| Aya Nakahashi | Production Assistant |
| Kumi Tanimoto | Production Assistant |
