 | Milla Jovovich als Alice |
 | Iain Glen als Dr. Isaacs |
 | Ali Larter als Claire Redfield |
 | Shawn Roberts als Albert Wesker |
 | Eoin Macken als Doc |
 | Fraser James als Razor |
 | Ruby Rose als Abigail |
 | William Levy als Christian |
 | Rola als Cobalt |
 | Ever Anderson als Alicia Marks / The Red Queen |
 | Lee Joon-gi als Commander Lee |
 | Siobhan Hodgson als Emaciated Woman |
 | Milton Schorr als Thin Man |
 | Aubrey Shelton als Scars |
 | Caroline Midgley als One Ear |
 | Dylan Skews als Commander Crunch |
 | Kevin Otto als Male Teacher |
 | Lee Raviv als School Girl |
 | Raquel Gecelter als School Child |
 | Vian Singleton als School Child |
| Stephanie Hough als Female Teacher |
 | Doug Chapman als Undead Russian |
 | Mark Simpson als James Marcus |
| Paul W. S. Anderson | Director |
| Paul W. S. Anderson | Producer |
| Jeremy Bolt | Producer |
| Paul W. S. Anderson | Writer |
| Robert Kulzer | Producer |
| Samuel Hadida | Producer |
| Paul Haslinger | Original Music Composer |
| Glen MacPherson | Director of Photography |
| Doobie White | Editor |
| Edward Thomas | Production Design |
| Lisa Van Velden | Art Direction |
| Christo Strydom | Art Department Coordinator |
| Laura Windows | Casting Associate |
| Joe Cappelletti | ADR Voice Casting |
| Sarah Notley | Researcher |
| Josue Clotaire Fleurimond | Conceptual Illustrator |
| Anneke Botha | Set Decoration |
| Guy Potgieter | Supervising Art Director |
| Tamarin Kotze | Script Supervisor |
| Lance Peters | Armorer |
| Louie Schultz | Music Editor |
| Michelle Karavoussanos | Assistant Costume Designer |
| Lars Cox | Camera Operator |
| John Gore | Drone Operator |
| Coco Van Oppens | Still Photographer |
| Ilze Kitshoff | Still Photographer |
| Sarel Pretorius | Steadicam Operator |
| Jason Martin | Underwater Camera |
| Peter Dydo | Lead Animator |
| Cordell McQueen | Special Effects Supervisor |
| Danielle Davis | Visual Effects Coordinator |
| Ryan MacDuff | Visual Effects Coordinator |
| Taylor McNutt | Visual Effects Coordinator |
| Brandon Schaafsma | Visual Effects Editor |
| Siubhan Smith | Visual Effects Producer |
| Greg Behrens | Visual Effects Producer |
| Luke Groves | Visual Effects Producer |
| Dennis Berardi | Visual Effects Supervisor |
| Eric Robinson | Visual Effects Supervisor |
| Steve Baine | Foley |
| Peter Persaud | Foley |
| John Loranger | Sound Designer |
| Doobie White | Sound Designer |
| Tyler Whitham | Sound Effects Editor |
| Alex Bullick | Sound Effects Editor |
| Kerry van Lillenveld | Property Master |
| Kerry Skelton | Hair Designer |
| Kerry Skelton | Hairstylist |
| Clinton Smith | Prosthetic Designer |
| Nelly Guimaras | Prosthetic Makeup Artist |
| Reon Van Der Watt | Stunt Double |
| Maria Labuschagne | Assistant Art Director |
| Riette Hayward | Assistant Hairstylist |
| Marli Kruger | Assistant Hairstylist |
| Marie Maggio | Assistant Hairstylist |
| Gabriella Pines | Assistant Hairstylist |
| Lian van Wyk | Assistant Hairstylist |
| Jessica Veasey | Assistant Hairstylist |
| Kerry Skelton | Hair Department Head |
| Christina Smith | Makeup Department Head |
| Daleen Badenhorst | Prosthetic Makeup Artist |
| Daleen Badenhorst | Wigmaker |
| Donovan Roberts-Baxter | Production Manager |
| Simon Damast | Production Manager |
| Christine Gouws | Art Department Assistant |
| Nkululeko Marais | Art Department Production Assistant |
| Tamara Gans | Art Department Trainee |
| Jos Joubert | Assistant Property Master |
| David van Rensburg | Assistant Property Master |
| Axel Hoebel | Assistant Set Decoration |
| Mogamat Achmat | Carpenter |
| Moegamat Dreyer | Carpenter |
| Ebrahim Du Preez | Carpenter |
| Yaasien Fieliers | Carpenter |
| Hector Ghiyaath | Carpenter |
| Esmodien Hendricks | Carpenter |
| Randall Herman | Carpenter |
| Nceba Mqikela | Carpenter |
| Blessing Muchinapo | Carpenter |
| Mawethu Ashley Ngange | Carpenter |
| Mogammat Igshaan Benjamin | Carpenter |
| Nicolus Lusse | Carpenter |
| Nkosinati Kalipa | Carpenter |
| Darren Christian | Concept Artist |
| Joshua Nel | Concept Artist |
| Elzaan Wilson | Construction Coordinator |
| Brendan Smithers | Construction Manager |
| Ryan Madden | Draughtsman |
| Steve Paul Martin | Draughtsman |
| Granville Baron | Greensman |
| Kudakwashe Siyapeys | Greensman |
| Cobus Van Der Waal | Leadman |
| Daniel Toko Cubain | Painter |
| Michael Manuel | Painter |
| Jose Akhim Faustino | Painter |
| Bert Heynike | Property Buyer |
| David Ryan Chandler | Property Buyer |
| Kerry von Lillienveld | Property Master |
| Lloyd Msimanga | Set Decoration Buyer |
| Wilfred Kok | Set Designer |
| Malwande Sigabi | Set Designer |
| Wisane Kumbe | Swing |
| Zuko Mangwana | Swing |
| Enock Mateyu | Swing |
| Ibrahim Meite | Swing |
| Jacques Mobia | Swing |
| Buetumussa Ntela | Swing |
| Khaya Sibiya | Swing |
| Pitso Tong | Swing |
| Patrick Chitima | Swing |
| Jill Purdy | ADR Editor |
| Devin Doucette | ADR Recordist |
| Howard London | ADR Recordist |
| Nick Kray | ADR Recordist |
| Travis MacKay | ADR Recordist |
| Simon Rankin | Boom Operator |
| Jill Purdy | Dialogue Editor |
| Rose Gregoris | First Assistant Sound Editor |
| Steve Baine | Foley Artist |
| Peter Persaud | Foley Recordist |
| Gina Gyles | Foley |
| Kevin Banks | Sound Editor |
| Nico Louw | Sound Mixer |
| Andrew Stirk | Sound Re-Recording Mixer |
| Andrew Tay | Sound Re-Recording Mixer |
| Mark Zsifkovits | Sound Re-Recording Mixer |
| Stephen Barden | Supervising Sound Editor |
| Maeve Slemon | Costume Coordinator |
| Christopher Beukes | Costume Illustrator |
| Deon de Lange | Costume Illustrator |
| Rial De Wet | Costume Illustrator |
| Karl Schulschenk | Costume Illustrator |
| Clinton Booyse | Costume Set Supervisor |
| Bianca Erasmus | On Set Dresser |
| Jeremy Johnson | On Set Dresser |
| Roseline Kannemeyer | On Set Dresser |
| Rick de Souza | On Set Dresser |
| Terence Norman | On Set Dresser |
| Shahieda Abrahams | Seamstress |
| Louisa Johnson | Seamstress |
| Noeneesa Majiep | Seamstress |
| Moenesa Majiet | Seamstress |
| Violet Metsi | Seamstress |
| Mbali Gladys Silere | Seamstress |
| Gafa Strachan | Seamstress |
| Miriam Williams | Seamstress |
| Tyrell Kemlo | Special Effects Coordinator |
| Ayanda Bara | Special Effects Technician |
| Genevieve Bevan-John | Special Effects Technician |
| Malcolm Cochrane | Special Effects Technician |
| Vuyisa Magafela | Special Effects Technician |
| Mxolisi Alfred Mkhutshwa | Special Effects Technician |
| Leonard Muchokoto | Special Effects Technician |
| Tim Muchokoto | Special Effects Technician |
| Michael Ngaba | Special Effects Technician |
| Sibusiso Nkosi | Special Effects Technician |
| Mzuvikile Sapaqa | Special Effects Technician |
| Emil Snyman | Special Effects Technician |
| Sithembiso Sontshaka | Special Effects Technician |
| Antonie Vorster | Special Effects Technician |
| Oscar Engelbrecht | Armorer |
| Ian Hatton | Armorer |
| Sheena Peters | Armory Coordinator |
| Marius Matthee | First Assistant Accountant |
| Ashleigh Potgieter | First Assistant Accountant |
| Sonia Terzyan | First Assistant Accountant |
| Ozayr Vally | Health and Safety |
| Felicitas Achelis | Legal Services |
| Gwendolin Grethe | Legal Services |
| Katja Kessler | Legal Services |
| Laurie Alexander | Legal Services |
| Nicholas Hanks | Legal Services |
| Jimmy Fraser | Marine Coordinator |
| Tisha Dames | Payroll Accountant |
| Sara Holmes | Post Production Accountant |
| Gail Mannion | Production Accountant |
| Jade Manuel | Production Coordinator |
| Robyn Snell | Production Coordinator |
| Yasmina Majid | Production Coordinator |
| Arushani Govender | Production Coordinator |
| Sarah Crompton | Production Executive |
| Tiffany von Willingh | Production Secretary |
| Lahli Mahloane | Production Trainee |
| Sesethu Somdaka | Production Trainee |
| Lebo Thobang | Production Trainee |
| Wiebke Döhla | Publicist |
| Ashley Aldworth | Script Supervisor |
| Kim Kemlo | Second Assistant Accountant |
| Kelsey Hoffe | Set Production Assistant |
| Kyle Steyn | Set Production Assistant |
| Tara Zulu | Set Production Assistant |
| Bianca Vandewalle | Set Production Assistant |
| Sobs Banisi | Set Production Assistant |
| Grant Wright | Set Production Assistant |
| Dezi Rorich | Unit Publicist |
| Travers Randall | Best Boy Electric |
| Tyron Mountjoy | Best Boy Electric |
| Djuma Masudi | Best Boy Grip |
| Craig Hattingh | Best Boy Grip |
| Marco Bartkowiak | Camera Operator |
| Don Cherel | Camera Operator |
| Tanile Jansen | Camera Trainee |
| Kwandiwe Lavisa | Camera Trainee |
| Samantha Davids | Camera Loader |
| Hennie Le Roux | Data Wrangler |
| Nigel Tompkins | Digital Imaging Technician |
| Bohdi Schoeman | Dolly Grip |
| Keith Johnson | Dolly Grip |
| Justice Amadi | Electrician |
| Zubair Gani | Electrician |
| Rameesh Herbert | Electrician |
| Elvis Ayuk Akum Mbae | Electrician |
| Moeketsi Mbele | Electrician |
| Julius Ndakwa | Electrician |
| Jinny Gunuza | Electrician |
| Patrick Mahanuke | Electrician |
| Jan Du Toit | Epk Camera Operator |
| Frank Gardner | First Assistant "A" Camera |
| Adrian Boerlage | First Assistant "A" Camera |
| Meike Chinnery | First Assistant "B" Camera |
| Manuel Khalid | First Assistant "B" Camera |
| John McKay | Gaffer |
| Clint Stone | Gaffer |
| Fundisile Mbinda | Generator Operator |
| Cameron Nqabeni | Generator Operator |
| Apiwe Diko | Grip |
| Gilbert Hitula | Grip |
| Bafana Langa | Grip |
| Mafika Masombuka | Grip |
| Isaac Ndlovu | Grip |
| Villy Nkoana | Grip |
| Patrick Rikhotso | Grip |
| Tobias Schoneveld | Grip |
| Ntsikilelo Fiyane | Grip |
| J.P. Ridgway | Key Grip |
| Chris Hope | Key Grip |
| Alfre Theron | Key Grip |
| Dan Sigobongo | Key Rigging Grip |
| Keegan Horn | Libra Head Technician |
| Brad Maloney | Libra Head Technician |
| Dudley Fillies | Rigging Gaffer |
| Emmanuel Chonco Sithole | Rigging Gaffer |
| Khaya Fokwana | Rigging Grip |
| Vern Nobles | Second Unit Director of Photography |
| Margaret Muggleston | Second Assistant "A" Camera |
| Bernard Sterk | Second Assistant "A" Camera |
| Simone Howlett | Second Assistant "B" Camera |
| Toto Dzingwa | Second Assistant "B" Camera |
| Francois Steyn | Techno Crane Operator |
| Pierre De Villiers | Video Assist Operator |
| Simon Wright | Video Assist Operator |
| Eileen de Klerk | Additional Editor |
| Thomas Tedesco | Assistant Editor |
| Allan Taylor | Colorist |
| Mitch Paulson | Digital Intermediate Colorist |
| Adrian Saywell | Digital Intermediate Editor |
| Peter Armstrong | Digital Intermediate Producer |
| Amy K. Bostrom | First Assistant Editor |
| Katie Cammaert | Post Production Coordinator |
| Byron Tofas | Compositing Lead |
| Angelica Lisk-Hann | Stunts |
| Wilmarie Janse Van Rensburg | Stunt Double |
| Jenny Umbhau | Stunt Double |
| Leanne Mullon | Stunt Double |
| Anneli Muller | Stunt Double |
| Cordell McQueen | Stunt Double |
| Katie McDonnell | Stunt Double |
| Caprice Masinga | Stunts |
| Lee-Anne Liebenberg | Stunts |
| Colleen Knox | Stunts |
| Malin Kirjonen | Stunt Double |
| Daniela Kahl | Stunt Double |
| Olivia Jackson | Stunt Double |
| Katja Hopkins | Stunts |
| Brenda Firmani | Stunt Double |
| Suzanne Smith | Casting |
| Christopher Minos | Animation |
| Josh Brown | First Assistant Sound Editor |
| Abigail Hard | Stunts |
