 | Jennifer Hudson als Aretha Franklin |
 | Forest Whitaker als C. L. Franklin |
 | Marlon Wayans als Ted White |
 | Audra McDonald als Barbara Franklin |
 | Mary J. Blige als Dinah Washington |
 | Marc Maron als Jerry Wexler |
 | Tituss Burgess als Reverend Dr. James Cleveland |
 | Saycon Sengbloh als Erma Franklin |
 | Hailey Kilgore als Carolyn Franklin |
 | Tate Donovan als John Hammond |
 | Skye Dakota Turner als Aretha Franklin (young) |
 | Heather Headley als Clara Ward |
 | Leroy McClain als Cecil Franklin |
 | Lodric D. Collins als Smokey Robinson |
 | Brenda Nicole Moorer als Brenda Franklin |
 | Brandon Gilpin als Teenager |
 | Tangela Large als Grieving Mother |
 | Albert Jones als Ken Cunningham |
 | Myk Watford als Rick Hall |
 | Gilbert Glenn Brown als Martin Luther King Jr. |
 | Kimberly Scott als Mama Franklin |
 | Nevaeh Moore als Young Carolyn |
 | Victoria Paige Watkins als Teen #2 |
| Liesl Tommy | Director |
| Tracey Scott Wilson | Screenplay |
| Scott Bernstein | Producer |
| Harvey Mason Jr. | Producer |
| Jason Cloth | Executive Producer |
| Aaron L. Gilbert | Executive Producer |
| Clint Ramos | Costume Design |
| Tracey Scott Wilson | Story |
| Callie Khouri | Story |
| Stacey Sher | Executive Producer |
| Harvey Mason Jr. | Executive Music Producer |
| Jennifer Hudson | Executive Producer |
| Jonathan Glickman | Producer |
| Sue Baden-Powell | Executive Producer |
| Kris Bowers | Original Music Composer |
| Kramer Morgenthau | Director of Photography |
| Avril Beukes | Editor |
| Tiffany Little Canfield | Casting |
| Bernard Telsey | Casting |
| David Vaccari | Casting |
| Ina Mayhew | Production Design |
| Mark Dillon | Supervising Art Director |
| Marybeth Dillon | Art Direction |
| Sarah Carter | Decorator |
| Cathy T. Marshall | Set Decoration |
| Natasha Arellano | Makeup Artist |
| Charmaine Balcerzak | Hairstylist |
| Andrea Bowman | Key Hair Stylist |
| Suzanna Boykin | Hairstylist |
| Christy Caudle | Additional Hairstylist |
| Moe Coles | Additional Hairstylist |
| Libra Cordero | Key Makeup Artist |
| Lawrence Davis | Hair Department Head |
| Margina Dennis | Makeup Artist |
| A. Renea Dyson | Additional Hairstylist |
| Joyce Gilliard | Hairstylist |
| Mandrill Hardge | Additional Hairstylist |
| Delonda Harvey | Additional Hairstylist |
| Victor Jones-Moore | Hairstylist |
| Tracy P. Lawrence | Hairstylist |
| Jackie Lynch | Makeup Artist |
| Stevie Martin | Makeup Department Head |
| Cassandra Powell | Additional Hairstylist |
| Genyii Scott | Hairstylist |
| Parra Thomas | Makeup Artist |
| Irenia Vail | Hairstylist |
| Robert Wilson | Hairstylist |
| Aaron Worman | Makeup Artist |
| Ann Gray | Post Production Supervisor |
| Paul A. Levin | Post Production Supervisor |
| Simi Wein | Production Supervisor |
| Leah Winkler | Production Supervisor |
| Kate Bilinski | Sound Effects Editor |
| Greg Crawford | ADR Mixer |
| Matt Hovland | ADR Mixer |
| Paul Hsu | Sound Re-Recording Mixer |
| Kenton Jakub | ADR Editor |
| Frank Kern | Foley Editor |
| Hunter Moore | Boom Operator |
| Julia Stockton | Dialogue Editor |
| Philip Stockton | Supervising Sound Editor |
| Thomas Varga | Sound Mixer |
| Ed White | Sound Mixer |
| Mark Wilkening | ADR Mixer |
| Jerry Yuen | Boom Operator |
| Anthony Bradley | Special Effects Coordinator |
| Thomas Kerns | Special Effects Technician |
| Joseph Sacco | Special Effects Technician |
| Praveen Allu | Digital Compositor |
| Ed Bruce | Visual Effects Supervisor |
| Alex Hillkurtz | Set Dresser |
| Chris McGlamery | Set Dresser |
| Rob Nagy | Set Designer |
| Diana Salzburg | Set Decoration Buyer |
| Wendy Gipp | Visual Effects Producer |
| Caoimhe Maguire | Visual Effects Producer |
| John P. Nugent | Visual Effects Supervisor |
| Ben Sumner | VFX Artist |
| Kenyatta Williams | Set Costumer |
| Munee Hayes | Costume Supervisor |
| Crystal D. Brown | Costume Supervisor |
| Daniel L. Smith | Digital Compositor |
| Kate Stauduhar | Visual Effects Editor |
| Heather Taylor | Visual Effects Editor |
| Christopher Cheng | Digital Compositor |
| Aldo Ruggiero | Visual Effects Supervisor |
| Andrew Prescott | Visual Effects Producer |
| Chris LeDoux | Executive Visual Effects Producer |
| Brad Kalinoski | Visual Effects Supervisor |
| Duncan Key | Digital Compositor |
| Daniel Dupre | Matte Painter |
| Nicholas Daniels | Digital Compositor |
| Andrew Byrne | Visual Effects |
| Matt Akey | Executive Visual Effects Producer |
| Brandon Kachel | Matte Painter |
| Gary Archer | Prosthetics |
| Adam Keane | Visual Effects Production Assistant |
