 | Robert De Niro als Detective Tom 'Turk' Cowan |
 | Al Pacino als Detective Dave 'Rooster' Fisk |
 | Carla Gugino als Karen Corelli |
 | John Leguizamo als Detective Simon Perez |
 | 50 Cent als Spider |
 | Donnie Wahlberg als Detective Ted Riley |
 | Brian Dennehy als Lieutentant Hingis |
 | Trilby Glover als Jessica |
 | Melissa Leo als Cheryl |
 | Sterling K. Brown als Rogers |
 | Shirly Brener als Natalya |
 | Rob Dyrdek als Rambo |
 | Liza Colón-Zayas als Judge Angel Rodriguez |
 | Oleg Taktarov als Yevgeny Mugalat |
 | Saidah Arrika Ekulona als Gwen Darvis |
 | Mia Barron als Jill Goldman |
 | Fatso-Fasano als Stubby |
 | Malachy McCourt als Father Connell |
 | Ajay Naidu als Dr. Chadrabar |
 | Terry Serpico als Jon Van Luytens |
 | Frank John Hughes als Charles Randall |
 | Alan Blumenfeld als Martin Baum |
 | Barry Primus als Prosky |
 | Andre B. Blake als Officer Jones |
 | John Cenatiempo als Joseph Cianci |
 | Judy Del Giudice als Hostess |
 | Bryan Chatlien als Ellis Lynde |
 | Merritt Wever als Rape Victim |
| Tyrone Smith als Fly Ty |
 | Katarzyna Wolejnio als Dancer |
 | Kimberly Dorsey als Waitress (uncredited) |
| Kimberly Magness als Club Dancer (uncredited) |
 | Alan Rosenberg als Stein |
| Jon Avnet | Director |
| Russell Gewirtz | Writer |
| Paul Hirsch | Editor |
| Ed Shearmur | Original Music Composer |
| Nancy Klopper | Casting |
| Denis Lenoir | Director of Photography |
| Kathy Lucas | Set Decoration |
| Tracey Gallacher | Production Design |
| Debra McGuire | Costume Design |
| Christina Ann Wilson | Art Direction |
| Rob Cowan | Producer |
| Lati Grobman | Producer |
| Alexandra Milchan | Producer |
| Randall Emmett | Producer |
| Avi Lerner | Producer |
| Jon Avnet | Producer |
| Daniel M. Rosenberg | Producer |
| Danny Dimbort | Executive Producer |
| Trevor Short | Executive Producer |
| Boaz Davidson | Executive Producer |
| George Furla | Executive Producer |
| Marsha Oglesby | Co-Producer |
| Lisa McNeil | Script Supervisor |
| Robert Griffon Jr. | Property Master |
| Linda Montanti | First Assistant Director |
| Brian E. Frankish | Production Manager |
| Oren Senderman | Production Supervisor |
| Sacha Quarles | Hair Department Head |
| Michelle Vittone | Makeup Department Head |
| Rose Chatterton | Key Hair Stylist |
| Julie Kristy | Key Makeup Artist |
| Devon Heffley Curry | ADR Supervisor |
| Michael K. Bauer | Music Editor |
| Ashley Waldron | Music Supervisor |
| Selena Arizanovic | Music Coordinator |
| Anton Holden | Dialogue Editor |
| Tim Terusa | Dialogue Editor |
| G. Michael Graham | Supervising Sound Editor |
| Craig Kyllonen | ADR Recordist |
| Jonathan Wales | Sound Re-Recording Mixer |
| Terry O'Bright | Sound Re-Recording Mixer |
| Stephen Grubbs | Foley Editor |
| Jill Schachne | Foley Artist |
| David Torres | Foley Mixer |
| Sharon Michaels | Foley Artist |
| Tim Chilton | Foley Artist |
| Oscar Zambrano | ADR Recordist |
| Rich Crescenti | ADR Recordist |
| Paul Tirone | ADR Recordist |
| Erich Gann | Sound Effects Editor |
| Bob Costanza | Sound Effects Editor |
| Mike Dickeson | Sound Effects Editor |
| Richard Steele | Sound Effects Editor |
| Mathew Price | Production Sound Mixer |
| Scott Hinkley | Additional Sound Re-Recording Mixer |
| Judah Getz | ADR Mixer |
| Beauxregard Neylon | ADR Mixer |
| Brian Magrum | ADR Mixer |
| Andrew Morgado | ADR Mixer |
| Michael Primmer | Boom Operator |
| Lori A. Lopes | Art Department Coordinator |
| Isabelle Trichard | Art Department Coordinator |
| Duane Manwiller | Camera Operator |
| Duane Manwiller | Steadicam Operator |
| Luke Geissbuhler | Second Unit Director of Photography |
| Christopher Duskin | Camera Operator |
| Dan Ayers | Steadicam Operator |
| Barbara Harris | ADR Voice Casting |
| Jessica Daniels | Casting Associate |
| Lorraine Z. Calvert | Assistant Costume Designer |
| Mohamed Khan | Production Coordinator |
| Caroline Vexler | Stunts |
| Ava Lee Scott | Stunt Double |
| Ava Lee Scott | Stunts |
| Jennifer Lamb | Stunt Double |
| John Cenatiempo | Stunt Double |
| Buddy Joe Hooker | Stunt Coordinator |
