 | Andy Serkis als Caesar |
 | James Franco als Will Rodman |
 | Freida Pinto als Caroline Aranha |
 | John Lithgow als Charles Rodman |
 | Brian Cox als John Landon |
 | Tom Felton als Dodge Landon |
 | Tyler Labine als Robert Franklin |
 | Karin Konoval als Maurice / Court Clerk |
 | Terry Notary als Rocket / Bright Eyes |
 | Christopher Gordon als Koba |
 | Richard Ridings als Buck |
 | Devyn Dalton als Cornelia |
 | Jay Caputo als Alpha |
 | David Hewlett als Douglas Hunsiker |
 | David Oyelowo als Steven Jacobs |
 | Jamie Harris als Rodney |
 | Ty Olsson als Chief John Hamil |
 | Joey Roche als Todd Hunsiker |
| Madison Bell als Alice Hunsiker |
 | Makena Joy als Alice Hunsiker (Teen) |
 | Kevin O'Grady als Animal Control Officer #1 |
 | Sean Tyson als Animal Control Officer #2 |
 | Kyle Riefsnyder als CHP #1 |
| Anthony McRae als CHP #2 |
 | Jesse Reid als Donnie Thompson |
 | BJ Harrison als Dottie |
 | Leah Gibson als Party Girl #1 |
 | Tracy Spiridakos als Party Girl #2 |
 | Ivan Wanis-Ruiz als Handler @ Lab #1 |
 | Trevor Carroll als Handler @ Lab #2 |
 | Chelah Horsdal als Irena - Charles' Nurse |
 | Mattie Hawkinson als Linda - Lab Tech |
 | James Pizzinato als Lab Tech |
 | Ryan Jefferson Booth als South Side Commander |
| Gordon Douglas Myren als Local Guy |
| Elizabeth Weinstein als Mom in Muir Woods |
 | Jeb Beach als Dad in Muir Woods |
| Jack Kuris als Boy in Muir Woods |
| Meredith Grantier als New Aide |
| Javier Caballero Cano als Newspaper Dad |
 | Peter Bundic als Newspaper Boy #1 |
| Dylan Nouri als Newspaper Boy #2 |
| Derek Morrison als Security Guard #1 |
 | Dean Redman als Security Guard #2 |
 | Hector Johnson als Security Guard #3 |
 | David Richmond-Peck als Board Member #1 |
 | Adrian Hough als Board Member #2 |
| Evans Johnson als Board Member #3 |
 | Qayam Devji als Todd's Buddy |
| Riel Hahn als Zoo Guide |
 | Michael Kopsa als Jerk Driver |
| Steve Lawlor als SFPD #1 |
 | Chris Shields als SFPD #2 |
 | Sandy Robson als SFPD #3 |
 | Mike Dopud als Northside Officer |
| Stacey Schmidt als Jogger |
| Willy Miles als Guy with Newspaper |
| Adrian Hein als Sharp Shooter |
| Trevor Addie als Ape (uncredited) |
| Jeffery Aro als Ape (uncredited) |
| Trevor Jones als Ape (uncredited) |
 | Camille Atebe als Playground Mom (uncredited) |
 | Rufus Dorsey als CHP #3 (uncredited) |
 | Sonja Bennett als Mother on Sidewalk (uncredited) |
 | Loyd Bateman als Ape (uncredited) |
 | Tom Franco als Mounted Officer (uncredited) |
 | Scott Lang als Ape (uncredited) |
| Matteo Mariotti als Child in Car (uncredited) |
 | Kis Yurij als Worker (uncredited) |
 | Frédéric North als Camera Ship Pilot (uncredited) |
| Sean Connor Roche als Teen Todd Hunsiker (uncredited) |
 | Luc Roderique als SWAT (uncredited) |
| Lauren Watson als Scared Girl in Stairway (uncredited) |
 | Timothy Webber als Janitor / Stan Timko (uncredited) |
| Linda Watters als Primate Lab Technician (uncredited) |
| Monica Mustelier als Lab Tech #3 (uncredited) |
| Rupert Wyatt | Director |
| Rick Jaffa | Screenplay |
| Amanda Silver | Screenplay |
| Derrick Auyoung | Animation Director |
| Jeremy Hollobon | Animation Director |
| Peter Chernin | Producer |
| Dylan Clark | Producer |
| Rick Jaffa | Producer |
| Amanda Silver | Producer |
| Renée April | Costume Design |
| Claude Paré | Production Design |
| Elizabeth Wilcox | Set Decoration |
| Patrick Doyle | Original Music Composer |
| Debra Zane | Casting |
| Andrew Lesnie | Director of Photography |
| Tom Meade | Animation Director |
| Dan Hermansen | Art Direction |
| Grant Van Der Slagt | Art Direction |
| Sharon Thompson | Art Department Coordinator |
| Keith Lackey | Animation Director |
| Lori Smallwood | Animation Director |
| Regina Cachuela | Animation Director |
| Taylor Carrasco | Animation Director |
| Daniel Barrett | Animation Supervisor |
| Eric Reynolds | Animation Supervisor |
| Jeff Capogreco | Digital Effects Supervisor |
| Mike Perry | Digital Effects Supervisor |
| Rachel Faith Hanson | Visual Effects Producer |
| Blaine Lougheed | Visual Effects Coordinator |
| Ron Pogue | Visual Effects Coordinator |
| Cyndi Ochs | Visual Effects Producer |
| Dan Lemmon | Visual Effects Supervisor |
| Justin Cornish | Visual Effects Supervisor |
| Brooke Lyndon-Stanford | Visual Effects Supervisor |
| Allan Magled | Visual Effects Supervisor |
| R. Christopher White | Visual Effects Supervisor |
| Erik Winquist | Visual Effects Supervisor |
| Conrad Buff IV | Editor |
| Mark Goldblatt | Editor |
| Darryl Marko | Boom Operator |
| Dawn Fintor | Foley |
| Alicia Stevenson | Foley |
| John Murray | Foley |
| David Grimaldi | Sound Effects Editor |
| Wayne Lemmer | Sound Effects Editor |
| John Morris | Sound Effects Editor |
| Ron Bartlett | Sound Re-Recording Mixer |
| Smokey Cloud | First Assistant Sound Editor |
| John A. Larsen | Supervising Sound Editor |
| Courtney Daniel | Assistant Costume Designer |
| Jana MacDonald | Costume Supervisor |
| Anne Burke | Set Costumer |
| Pamela Cameron | Set Costumer |
| Eilidh McAllister | Set Costumer |
| Karen McVey | Seamstress |
| Lynette Schlichting | Seamstress |
| Jessica Clothier | Script Supervisor |
| Andrea Devaux | Script Supervisor |
| Heike Brandstatter | Casting |
| Coreen Mayrs | Casting |
| Pamela Pearl | Casting Associate |
| Lisa Zambetti | Casting Associate |
| Amy Nygaard | Casting Associate |
| Dean Heselden | Camera Operator |
| Stephen Maier | Camera Operator |
| Harry K. Garvin | Camera Operator |
| Tim Bellen | Camera Operator |
| Steven R. Mathis | Gaffer |
| Burton 'Joe' Kuchera | Gaffer |
| Dean Des Jarais | Gaffer |
| Stuart Haggerty | Gaffer |
| Jarrod Tiffin | Rigging Gaffer |
| Phil Pastuhov | Helicopter Camera |
| Larry Blanford | Helicopter Camera |
| Peter Wilke | Steadicam Operator |
| Kevin McCloy | Rigging Grip |
| Joseph Lederer | Still Photographer |
| Kieran Humphries | First Assistant Camera |
| Taylor Matheson | First Assistant Camera |
| Paul Guenette | First Assistant Camera |
| Nicholas McKenzie | First Assistant Camera |
| Sherry Linder-Gygli | Hair Department Head |
| Debra Johnson | Key Hair Stylist |
| Victoria Down | Makeup Department Head |
| Chris Benstead | Music Editor |
| Jeanette Surga | Music Editor |
| Patrick Doyle | Orchestrator |
| Curtis Lindersmith | Digital Intermediate |
| Eileen Godoy | Digital Intermediate |
| Steve Ansell | First Assistant Editor |
| Jason Dale | First Assistant Editor |
| Carole A. Kenneally | First Assistant Editor |
| Tyler Ruocco | First Assistant Editor |
| Helen Jarvis | Supervising Art Director |
| John Dale | Construction Coordinator |
| Kevin Clark | Greensman |
| Dean Eilertson | Property Master |
| Jan Kobylka | Construction Coordinator |
| Sheila Millar | Set Designer |
| Jacques Paradis | Construction Foreman |
| Rob Fournier | Armorer |
| Susan Dawes | Dialogue Editor |
| Mark Vargo | Second Unit Director of Photography |
| Jim Brookshire | ADR Editor |
| R.J. Kizer | ADR Editor |
| Mildred Iatrou | ADR Supervisor |
| Joe Letteri | Senior Visual Effects Supervisor |
| Graham Binding | Senior Animator |
| Jerad Marantz | Character Designer |
| Angela Uyeda | Stunts |
| Melissa R. Stubbs | Stunts |
| Sharon Simms | Stunts |
| Tarah Paige | Stunts |
| Jennifer Mylrea | Stunts |
| Carol Jackson | Stunts |
| Caroline Field | Stunts |
| Duane Dickinson | Stunts |
| Crystal Dalman | Stunts |
| Janina Dall | Stunts |
| Doug Chapman | Stunts |
| Dana Dru Evenson | Stunts |
| Corry Glass | Stunts |
| Brian Smrz | Second Unit Director |
| Brett Armstrong | Stunts |
| Lauro Chartrand | Stunts |
| Thomas M. Hammel | Executive Producer |
